United Tribes Technical College (UTCC) is a private tribal land-grant community college in Bismarck, North Dakota. In 2012, UTTC had an enrollment 885 students, 635 full-time undergraduates, and 250 part-time undergraduates.
Data science skills are essential for advancing knowledge of health inequities in marginalized and medically underserved populations. As of 2021 there were no programs in data science in the Tribal Colleges and Universities in North Dakota and the neighboring states. The Virtual Indigenous Data Science Academy was established in 2021 by the University of North Dakota School of Medicine and Health Sciences in collaboration with three North Dakota Tribal Colleges to introduce Indigenous students to the core elements of data science. The Virtual Indigenous Data Science Academy teaching faculty designed, developed, delivered, and evaluated a culturally-informed online synchronous summer program consisting of ten learning modules. The Virtual Indigenous Data Science Academy was delivered synchronously over three consecutive summers (2022-2024) to a total of 48 Tribal college students with diverse backgrounds and academic interests. More than 70% of student participants met the skills-based learning objectives of the Academy. Results of the summer program student evaluations demonstrated higher than average ratings of satisfaction with the instruction. The VIDS Academy represents a promising model for the delivery of instruction in data science and Science, Technology, Engineering, and Mathematics-related fields that address the local workforce and healthcare needs of Tribal communities.
The Na+/K+-ATPase consumes a substantial portion of cellular ATP to maintain essential electrochemical gradients, yet its role in regulating cancer cell proliferation and phenotypic plasticity remains complicated by its dual function as an ion transporter and a scaffolding receptor. Here, we investigate the physiological consequences of pharmacological NKA blockade using digoxin in K562 human chronic myelogenous leukemia cells. Submicromolar digoxin exposure induced a concentration-dependent attenuation of cell proliferation (IC50= 151.0 nM) and a statistically significant depression of metabolic reducing capacity without impairing cell viability. Competitive supplementation with extracellular potassium salts produced a surmountable rightward shift in digoxin sensitivity, confirming that growth inhibition is driven by on-target NKA pump occupancy rather than non-specific interactions. Furthermore, this cytostatic growth attenuation and metabolic depression were found to be fully reversible upon drug clearance. K562 cells are largely refractory to canonical kinase-overdrive stress checkpoints as they harbor constitutive BCR-ABL tyrosine kinase activity alongside non-functional TP53 and a homozygous deletion of CDKN2A (p16INK4a). Consequently, these findings suggest that NKA perturbation attenuates K562 growth primarily through ion dyshomeostasis and secondary active transport constraints rather than scaffold-mediated signaling. Overall, we present a novel model for elucidating the role of the NKA in cancer proliferation and dissecting the mechanistic underpinnings of ion-mediated alterations in cancer cell physiology. ### Competing Interest Statement The authors have declared no competing interest. NIH Common Fund, P20GM103442
There is a resurgent enthusiasm for Indigenous Knowledges (IK) across settler–colonial institutions of research, education, and conservation. But like fitting a square peg in a round hole, IK are being forced into colonial systems, and then only as marginal alternatives. To address this mismatch, the Traditional Ecological Knowledge Section of the Ecological Society of America (ESA) hosted a 2‐day workshop—entitled Elevating Indigenous Knowledges in Ecology—at the 2022 ESA Annual Meeting, which was held on Kanien'keháka (Mohawk) and Ho‐de‐no‐sau‐nee‐ga (Haudenosaunee) territories in Montreal, Canada. This gathering of 21 interdisciplinary Indigenous ecologists included scholars from across the career and professional spectrum. By consensus, workshop participants (including the authors of this article) identified four emergent themes and respective guiding questions as a pathway toward the transformation of settler–colonial institutions into IK‐led spaces. We highlight this pathway to support actions toward systemic change, inspire future directions for Indigenous and non‐Indigenous ecologists, and nurture stronger relationships between Indigenous communities and the Western sciences, toward actualized decoloniality.
This study introduces a novel oxygen-deficient perovskite, Sr2Fe0.75Co0.75Mn0.5O6-δ, synthesized through a solid-state reaction and thoroughly characterized by Powder XRD, SEM and direct current (DC) electrical conductivity measurements. The material, exhibiting a cubic crystal structure with the Pm3̅m space group, demonstrates intriguing electrical properties. At temperatures ranging from 25 to 400 °C, the material displays semiconductor-type conductivity, transitioning seamlessly to metallic-type conductivity from 400 to 800 °C. The deliberate incorporation of cobalt into the perovskite structure is found to be pivotal, as evidenced by a comparative analysis with its parent compound, Sr2FeMnO6-δ. This investigation reveals a substantial improvement in electrical conductivity, underscoring the significance of the partial substitution of cobalt. The tailored electrical properties of Sr2Fe0.75Co0.75Mn0.5O6-δ position it as a versatile candidate for electronic applications. Impact of Employee Compensation and Benefits on Operating Performance This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright © Author(s) retain the copyright of this article.
The crystal structure of CaSrFe0.75Co0.75Mn0.5O6−δ is investigated through neutron diffraction techniques in this study. The material is synthesized using a solid-state synthesis method at a temperature of 1200˚C. Neutron diffraction data is subjected to Rietveld refinement, and a comparative analysis with X-ray diffraction (XRD) data is performed to unravel the structural details of the material. The findings reveal that the synthesized material exhibits a cubic crystal structure with a Pm-3m phase. The neutron diffraction results offer valuable insights into the arrangement of atoms within the lattice, contributing to a comprehensive understanding of the material’s structural properties. This research enhances our knowledge of CaSrFe0.75Co0.75Mn0.5O6−δ, with potential implications for its applications in various technological and scientific domains.
