The University of Sonora (Universidad de Sonora, abbreviated as Unison) is a public university in the northwestern state of Sonora, Mexico that has a strong research program. The university was founded in 1942 and is considered the main cultural and educational driver in the state. The university motto is "El saber de mis hijos hará mi grandeza" ("The knowledge of my children will be my greatness"). It is the largest university of Sonora with about 30,000 students (about 28,000 for undergraduate studies and 2,000 for postgraduate studies) distributed in five campuses.Dr. Enrique Velázquez Contreras started his tenure as the University Rector in June 2017 for a period of four years (renewable). Under his leadership the university has prepared its Strategic Initiative putting special emphasis on the Internationalization of its academic and research programs..
In this work, we study the passive mode-locked and Q-switched mode-locked (QSML) operations of an erbiumdoped fiber ring laser with twisted fiber in the cavity. Using twisted fiber together with precisely adjusted wave retarders, this configuration allows very tight polarization control. As pump power was increased, the mode locking regime was first observed, which was spectrally centered at 1565 nm. By increasing the cavity gain (increasing pumping power), the spectrum shifts to a wavelength of 1530 nm, where a QSML regime is observed. In the QSML regime, the pulses envelopes have a global repetition period of the order of 11 mu s, whereas the internal separation period remains at 98 ns, consistent with the cavity length. The transitions between multiple laser emission regimes induced by increasing pump power allows the observation of polarization dynamics at the laser output, which is rarely studied. Distinct polarization regions were identified for each of these operating regimes.
Giardiasis is caused by the widespread intestinal parasite Giardia lamblia. The characterization of immunogenic proteins in G. lamblia has been investigated to identify potential vaccine targets, including members of the giardin family, variant-specific surface proteins (VSPs), cyst wall proteins (CWPs) and heat shock protein (HSP). The immunoglobulin-binding protein (BIP) is a HSP that has been described as immunogenic antigen; however, its role in this protozoan remains poorly characterized, particularly regarding its involvement in the humoral immune response activation, critical for parasite clearance. In this study, we evaluated the capacity of BIP to promote an antibody-mediated response through oral administration in mice. Additionally, we identified B-cell epitopes by integrated experimental and immunoinformatic approach. In mice, oral administration of BIP alone, without adjuvants, induced a specific humoral immune response at both systemic and mucosal levels, as well as, during Giardia infection, demonstrating its ability to disrupt the tolerogenic environment of the gut. Immunogenic regions of BIP were identified. A fragment around 7 kDa was recognized by specific-BIP polyclonal and monoclonal antibodies. This fragment contains two potential linear epitopes (the amino acids 64-132 and 176-190 of BIP protein) that are conserved in HSPs of other pathogens. Furthermore, in silico analyses identified additional B-cell epitopes distributed throughout the BIP sequence, reinforcing its antigenic potential. These findings support the ability of BIP to induce an efficient humoral immune response via the oral route, a key feature in infections such as giardiasis, thereby highlighting its potential as a target for vaccine development against Giardia.
The effect of post-sintering cooling procedure on the thermoluminescence (TL) dosimetric behavior of SrZrO3 synthesized by solid-state reaction was systematically investigated. Samples were sintered at 1400 degrees C for 36 h in air and subjected to either rapid cooling (quenching) or slow cooling (furnace cooling). Rietveld refinement of the X-ray diffraction pattern confirmed the formation of a single-phase orthorhombic structure (space group Pbnm) with refined lattice parameters a = 5.789881 & Aring;, b = 5.806877 & Aring;, and c = 8.196767 & Aring; (chi 2 = 1.19), and a crystallite size of 0.63 mu m by Debye-Scherrer analysis. Both cooling protocols yielded glow curves with a dominant emission maximum in the 259-265 degrees C range, suitable for thermoluminescence dosimetry. Glow-curve deconvolution resolved six first-order components with activation energies ranging from 0.71 to 1.21 eV. Unlike previous studies reporting non-linear TL response, both sample types exhibited linear dose-TL response over the full 1.0-128 Gy interval and outstanding cycle-to-cycle reproducibility with standard deviations below 1.0 % over ten successive irradiation-readout cycles. The lower detection limits were determined to be 3.29 mGy for the quenched sample and 1.15 mGy for the slowly cooled sample, representing an improvement of approximately 2 orders of magnitude relative to previously reported values for this phosphor. These results establish postsintering cooling rate as an effective processing variable for optimizing the dosimetric sensitivity of undoped SrZrO3, without requiring changes in chemical composition or sintering parameters, and allow consider the synthesized SrZrO3 phosphors as promising phosphor materials for developing dosimeters for precision radiation dosimetry.
In this study, ZnO/RE2O3 (RE = Nd, Yb) composites were prepared using the thermal decomposition method. The neodymium concentration was fixed at 2 mol
Boswellia serrata is a medicinal plant traditionally used to treat inflammatory conditions and this study aimed to evaluate the efficacy of B. serrata dry extract (BSDE) in treating gastric ulcers and ulcerative colitis. Chronic gastric ulcers were induced using 80
