The University of Arkansas for Medical Sciences (UAMS) is a public health sciences university in Little Rock, Arkansas. It is part of the University of Arkansas System and consists of six colleges, seven institutes, several research centers, a statewide network of community education centers, and the UAMS Medical Center.
Extracorporeal membrane oxygenation (ECMO) is increasingly being utilized for life-threatening cardiac and/or respiratory failure refractory to conventional treatment. Acute kidney injury (AKI) and fluid balance disorders commonly occur both before and during ECMO, with approximately half of cases receiving treatment with continuous renal replacement therapy (CRRT). Acute kidney injury, fluid balance disorders, and CRRT influence both short- and long-term outcomes in this population. The 36th Acute Disease Quality Initiative (ADQI) meeting was held in June 2025 to develop multidisciplinary international expert recommendations for AKI, fluid balance, and CRRT during ECMO across the age spectrum. This work encompassed five working groups: 1) epidemiology, risk factors, and outcomes of AKI and CRRT, 2) fluid management and outcomes, 3) indications for CRRT and fluid removal during ECMO, 4) best practices for performing CRRT during ECMO, and 5) biomarkers, extracorporeal blood purification, and drug pharmacokinetics and pharmacodynamics. As part of this work, knowledge gaps and research priorities were identified.
The prospective pediatric Continuous Renal Replacement Therapy (ppCRRT) registry identified the degree of fluid accumulation (FA) at continuous kidney replacement therapy (CKRT) initiation as a predictor of adverse outcomes in children. These predate major advancements in CKRT technology and fluid stewardship. We aimed to describe the epidemiology of FA at CKRT initiation and associated outcomes in a contemporary paediatric cohort. Secondary analysis of Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK), a retrospective, multicenter study (35 centers, 9 countries) of patients ≤ 25 years treated with CKRT from 2015 to 2021. Primary Outcome: survival to ICU discharge. Secondary outcomes: ventilator-free and ICU-free days. A total of 1027 patients were included in this analysis. Survival to ICU discharge was 64.5
Prospective, multi-institutional surgical data collection in pediatric neuro-oncology remains limited despite substantial variation in operative and perioperative management across institutions. To address this, we are developing the NeuroPoint Alliance (NPA) Quality Outcomes Database (QOD) Pediatric Tumor Surgery Registry. Here, we used a modified Delphi process to define a core outcome set for the registry. A modified Delphi study was conducted among pediatric neurosurgeons serving as site principal investigators for the proposed registry. Candidate data elements were rated on a 9-point Likert scale. Consensus for inclusion was predefined as ≥70
OBJECTIVE:To assess psychiatry faculty knowledge, use, and perceptions of artificial intelligence (AI) in undergraduate medical education (UME) and graduate medical education (GME), and examine awareness of institutional AI policies. METHODS:A national survey was distributed to psychiatry clerkship directors and residency program directors at 105 allopathic and osteopathic medical schools and 219 psychiatry residency programs across the USA from November 2024 to February 2025. The survey assessed AI use patterns, attitudes, perceptions, and awareness of institutional policies. Data were analyzed using descriptive statistics and Fisher's exact test for group comparisons. RESULTS:Responses were obtained from 31 UME faculty (29.5% response rate) and 46 GME faculty (21% response rate). All UME faculty and 74% of GME faculty believed students use AI. However, 36% of UME and 57% of GME faculty were unaware of institutional student AI policies. Knowledge of faculty AI policies was even more limited (38.7% UME, 63% GME uncertain). Only 35.5% of UME and 27.9% of GME faculty reported current AI use, primarily for research support, literature review, and content development. Overall, 50% of UME and 54.1% of GME respondents perceived AI in medical education as beneficial. CONCLUSIONS:Despite widespread belief that students use AI, psychiatry faculty demonstrate limited awareness of institutional policies and minimal integration of AI literacy in curricula. These findings highlight the urgent need for faculty development programs, clear institutional policies, and structured AI curricula to bridge the gap between rapid AI adoption by learners and educational infrastructure.
Tuberous sclerosis complex 1 (TSC1) is a negative regulator of mTORC1 signaling, a key pathway in skeletal homeostasis, but its region- and compartment-specific effects on bone remain unclear. Here, we examined the skeletal impact of Tsc1 deletion using the 8-kb Dmp1-Cre line, which targets mature osteoblasts and osteocytes. Cre activity in Ai14 reporter mice showed comparable recombination in craniofacial, appendicular, and axial bones. Conditional Tsc1 deletion resulted in greater bone mass at multiple sites, but with marked regional and compartmental variations. In the craniofacial skeleton, the frontal bone showed the most robust elevation in thickness and volume, the parietal bone displayed intermediate elevation, and the mandible exhibited the smallest elevation but reduced bone volume fraction and tissue mineral density, consistent with greater porosity. In femurs, both trabecular and cortical bone mass was augmented. Histomorphometric analysis of femoral trabecular bone revealed increased osteoblast number and surface together with reduced osteoclast parameters. In vertebrae, Tsc1 deletion produced modest trabecular bone accrual but > 100
