In health research, communities rarely receive findings in a form they can use. This problem is more complex in social network research, where findings are both relational and individual. The challenge compounds in rural, underserved settings, where low health literacy and limited exposure to scientific visualization severely constrain how results can be communicated. As part of a longitudinal personal network project on primary cancer prevention in rural areas, we developed an art gallery to return findings to the community. The installation was framed as a performative intervention that made relational structures visible, inviting awareness and reflection. It comprised seven digitally printed canvases and a three-dimensional network sculpture. Each item presented a level of social organization (personal network, household, community structure, socio-spatial concentration, and food culture) through designs intended for non-specialist viewers and supported by facilitation. The three-day exhibition attracted 103 visitors, all of whom rated its utility highly. It also revealed how the community reacted to findings about their rural context. This exploratory single-site study supports three lessons: linking each canvas to a single analytical level aided reading, the order of presentation helped viewers build a basic vocabulary for network visualization, and facilitation, more than the canvases alone, carried the interpretive work. Limitations include a single installation and ratings that seem to reflect acceptability and acquiescence rather than comprehension. Future work should directly evaluate understanding, compare reception across sites, and test refinements such as written legends. We describe a working approach, not a validated framework.
Melanoma remains a highly aggressive malignancy, particularly in advanced metastatic stages where therapeutic options are limited. Natural compounds provide a structural basis for discovering novel anticancer agents. In this study, we employed an integrated in silico approach to evaluate the pharmacokinetic properties, toxicity profiles, and molecular targets of key alkaloids from Chelidonium majus, including berberine, sanguinarine, chelerythrine, chelidonine, protopine, umbelliferone and coptisine. ADME/T predictions (SwissADME and DeepPK) revealed favorable drug-likeness and oral bioavailability for most compounds, with berberine exhibiting the most balanced safety and absorption profile. All compounds demonstrated high intestinal absorption (>99%) and implicated key melanoma targets, including APE1/Ref-1, CXCR4, CCR2, TLR8, galectin-3, and VEGFR2. These molecules represent valuable templates for the development of melanoma therapies. Among the tested compounds, chelidonine emerged as a potential APE1 inhibitor, exhibiting the highest binding affinity and forming specific interactions within the enzyme's catalytic site, suggesting its potential as a DNA repair-targeted agent in melanoma. These findings support the further exploration of natural alkaloids, including structural optimization or advanced formulation strategies, to enhance safety, bioavailability, and therapeutic efficacy in melanoma.
Nature-based solutions (NbS) aim to address pressing environmental challenges (e.g., the biodiversity and climate crisis) while simultaneously providing multiple socio-cultural and economic benefits. While injustices, such as unequal access to NbS benefits, displacement through green gentrification, or lack of community participation, are increasingly mapped, few studies have systematically identified approaches towards more inclusive NbS. This persistent gap underscores the need to identify and understand the key parameters of inclusive NbS. This study conducts a systematic literature review on cases of European NbS to define the characteristics that contribute to inclusive NbS. To this end, 280 scientific publications have been assessed through a network analysis approach. Our results highlight the importance of tailoring NbS to the site-specific characteristics and knowledge systems of local communities, while aligning them with broader urban policy frameworks to ensure integrated and equitable socio-economic and ecological outcomes. We found that to design inclusive NbS, it is essential to engage and properly address stakeholders’ needs, requirements, and values. This could help prevent the uneven enhancement of new green infrastructure initiatives or the unequal distribution of NbS benefits and enhance co-creation and accessibility to NbS for all. Particular attention should be directed towards ensuring that vulnerable groups are equitably represented in the decision-making processes. Our findings provide valuable insights for academia, policymakers, and practitioners to advance the integration of inclusive NbS into future research agendas, policy and governance frameworks, participatory citizen engagement strategies, and targeted interventions to address the needs of specific vulnerable groups.
Abstract In this paper we have revisited the energy–momentum squared gravity theory, by taking into account the second derivative of the matter Lagrangian with respect to the metric, encapsulating relations originated from thermodynamical grounds. The study has focused on the inclusion of new specific relations related to the second derivative of the matter Lagrangian with respect to the metric, giving rise to a different final form for the evolution equations in the scalar tensor representation. In the previous studies this term has been neglected, since it was associated to a possible divergence in the scenario where the matter component behaves like a non-relativistic collisionless fluid. After obtaining the scalar tensor representation of the energy–momentum squared gravity with the new corrections, we have analyzed the physical implications by relying on the linear stability theory. The results show that the current cosmological system is compatible with the expansion of the Universe for some specific matter Lagrangians, explaining the emergence of matter domination era, approaching the late time accelerated expansion era close to the de-Sitter phenomenology. In this case we have obtained possible analytical constraints for specific model’s parameters from the viewpoint of dynamical analysis.
Loss of old-growth and mature forests threatens the long-term persistence of saproxylic beetles, keystone species essential for ecosystem functioning. Effective conservation requires detailed knowledge of their habitat requirements and dispersal capacity, which remain poorly understood in Eastern Romanian Carpathians. In this study, we used radio-telemetry to examine the movement ecology and habitat selection of Osmoderma barnabita in a closed-canopy mature mixed broadleaved forest with scattered veteran trees, interspersed with hay meadow clearings (hereinafter mature mixed broadleaved forest) of the Eastern Romanian Carpathians, an area where the species' distribution and ecology have been largely underreported in the literature. Our VHF telemetry-informed study of Osmoderma barnabita found that female beetles recorded the longest movement distance (401 m) and had larger home ranges than males, while their core home ranges were similar. We found that Osmoderma barnabita showed a clear preference for Quercus petraea, with its presence best predicted by wood mould cavities, tree height and diameter. Additionally, selection for shaded microhabitats and limited movement suggests that the populations show distinct ecological responses, likely adapting to the drier, warmer summer conditions of the Eastern Romanian Carpathians. Our results provide insights into microhabitat and stand types suitable for Osmoderma barnabita in the Eastern Romanian Carpathians and emphasize the importance of larger trees with microhabitats that take a long time to develop (cavities with suitable substrates for oviposition). This may reflect local adaptation, responses to environmental conditions or early signs of climate-related range shifts.
