The Montpellier 1 University (Université Montpellier 1) is a French university, in the Academy of Montpellier. It is one of the three successor universities to the University of Montpellier following the split in 1970.In January 2015, Montpellier 2 University and Montpellier 1 University merged again to reform University of Montpellier..
BACKGROUND:Hip arthroscopy for femoroacetabular impingement yields favorable average results, yet many patients do not achieve truly excellent function. The influence of pre-operative radiographic and spinopelvic parameters on excellent short-term outcomes remains uncertain. We aimed to identify pre-operative radiographic and spinopelvic factors associated with achieving an excellent patient-reported outcome at 12 months after arthroscopic treatment of femoroacetabular impingement. METHODS:A retrospective multicenter study of prospectively collected data was performed across six French centers. Consecutive patients treated arthroscopically for symptomatic femoroacetabular impingement between September 2020 and October 2021 were included if the 12-month Non-Arthritic Hip Score was available. Standard hip radiographs were used to measure degenerative grade, lateral centre-edge angle, and the Dunn alpha angle. Spinopelvic parameters were assessed on low-dose biplanar imaging in standing and sitting, including intrinsic pelvic mobility (standing minus sitting sacral slope). The primary endpoint was an excellent outcome defined as a 12-month Non-Arthritic Hip Score of at least 92. Missing spinopelvic data were handled by multiple imputation, and univariate then multivariable logistic regression was used, adjusted for age, sex, and body mass index. RESULTS:Of 200 eligible patients, 178 (89.0%) had 12-month outcome data; 82 (46.1%) achieved a Non-Arthritic Hip Score of at least 92. In the adjusted model, standing pelvic tilt of 10 degrees or less (odds ratio 2.82; 95% confidence interval 1.35-5.90), degenerative grade 0 (odds ratio 5.15; 95% confidence interval 2.19-12.09), lateral centre-edge angle greater than 25 degrees (odds ratio 3.08; 95% confidence interval 1.41-6.74), and male sex (odds ratio 3.18; 95% confidence interval 1.38-7.32) independently predicted an excellent outcome. Intrinsic pelvic mobility, standing lumbar lordosis, Dunn alpha angle, age, and body mass index were not independently associated with excellent outcome. CONCLUSIONS:Only about half of patients undergoing hip arthroscopy for femoroacetabular impingement achieved an excellent 12-month outcome. Tonnis grade 0, lateral centre-edge angle greater than 25 degrees, standing pelvic tilt of 10 degrees or less, and male sex independently predicted excellent results, whereas pelvic mobility, standing lumbar lordosis, age, and body mass index did not.
BACKGROUND:A new N-terminal pro-B-type natriuretic peptide (NT-proBNP) immunoassay using de novo antibodies was developed on a DxI9000© analyzer from Beckman. The aim of this study was to assess its analytical performance, and a comparison with the Elecsys-proBNPII assay from Roche was also performed. NT-proBNP values in healthy adults based on sex and age were established, and clinical performance in the diagnosis of chronic heart failure (CHF), acute heart failure (AHF), aging, and chronic kidney disease (CKD) populations was evaluated. METHODS:Analytical performance of the Access NT-proBNP assay was evaluated. A method comparison was performed using 200 fresh plasma samples as well as with all the patient samples included in the study (n = 531). The distribution of Access NT-proBNP levels in healthy subjects, patients with CHF or AHF, and patients with CKD was reported. RESULTS:The total imprecision for NT-proBNP controls was 3.17% and 4.73%, and 3.70% and 10.45% in a plasma pool. The limit of blank and limit of detection were lower than those reported by the manufacturer. Correlation studies showed a good correlation between NT-proBNP measurements using the Access NT-proBNP assay and Roche analyzer.In a healthy population, the NT-proBNP concentrations increased across the age groups and significantly varied in healthy adult men and women throughout the years. In the different pathological situations studied, our results clearly demonstrated that the new NT-proBNP assay from Beckman meets European Society of Cardiology requirements for diagnostic approaches and monitoring of patients suspected of having chronic heart failure. CONCLUSION:The Access NT-proBNP assay showed acceptable analytical and diagnostic performance in heart failure. In cases of renal failure, our study encourages cautious interpretation of results.
Background: Short Daily Home Dialysis (SDHD) has been proposed as a patient-centered alternative to conventional in-center hemodialysis (ICHD). Methods: The multicenter Self-convecTive Evaluation of short daily home dialysis (SDHD) on Physical Activity (STEP-HD) observational and prospective cohort compared SDHD with ICHD over 12 months in France and Belgium. The primary endpoint was average daily step count, assessed using wearable activity trackers. Secondary outcomes included sleep, sedentary time, recovery after dialysis, laboratory parameters, quality of life, and treatment burden. Results: A total of 152 patients were enrolled (82 SDHD, 70 ICHD). At baseline, SDHD patients demonstrated 28% higher activity levels (6,673 vs 4,768 steps/day), a difference sustained throughout follow-up. Physical activity in ICHD patients was significantly lower on dialysis days, while SDHD patients maintained stable patterns. Sleep duration was greater un SDHD (up to 405 minutes/day) and lower in ICHD (to 202 minutes/day). Sedentary time remained consistently lower and recovery time tended to be shorter in SDHD (60 vs 120 minutes). Laboratory analyses showed lower predialysis β2-microglobulin and preserved nutritional markers in SDHD, despite similar anemia and metabolic control. Conclusions: Compared with ICHD, SDHD was associated with sustained preservation of physical activity, better post-dialysis recovery, improved sleep, and reduced sedentary burden, supporting its use as a safe and patient-centered modality.
Background:Community-acquired bacterial meningitis remains associated with high mortality and neurological disability in critically ill adults. Contemporary data on outcomes in mechanically ventilated patients and on the role of invasive intracranial pressure monitoring are limited. We aimed to describe 90-day outcomes, identify predictors of unfavorable neurological outcome, and evaluate the association between invasive intracranial pressure monitoring and prognosis in mechanically ventilated adults with community-acquired bacterial meningitis. Methods:Retrospective multicenter cohort study (2012-2023) across 26 French ICUs. The primary endpoint was unfavorable functional outcome at day 90 (modified Rankin Scale score 3-6), assessed using multivariable mixed-effects regression and propensity score-based overlap weighting. Findings:Among 704 included patients (median age, 66 years [IQR, 48-70 years]; 421 men [59.8%]), 354 (50.3%) had an unfavorable outcome at day 90, including 220 (31.3%) who died. Independent predictors of unfavorable outcome included older age, septic shock, acute kidney injury, coagulation disorders, lower motor score on the Glasgow Coma Scale, pupillary abnormalities, and abnormal brain imaging findings at presentation. Appropriate initial antimicrobial therapy, along with adjunctive dexamethasone, was associated with improved outcomes. Invasive intracranial pressure monitoring was performed in 84/704 patients (11.9%) and was not associated with improved functional outcome in the overall cohort (odds ratio, 0.97; 95% CI, 0.48-1.96) or in prespecified subgroups. Interpretation:In this large real-world cohort, 90-day mortality and disability remain high and are largely driven by initial neurological and systemic severity. Invasive intracranial pressure monitoring was not associated with improved outcomes, and no clear benefit was identified in this observational analysis. Funding:None.
