University of Rajasthan is a public and state university and is one of the oldest universities in the Indian state Rajasthan, located in the city Jaipur. It was set up on 8 January 1947 as the University of Rajputana and was given its current name in the year 1956.
Signal Transducers and Activators of Transcription (STATs) are transcription factors which are involved in JAK/STAT phosphorelay signaling in animals. Although STATs are well characterized in metazoans including humans, their role in plants is not well understood. To fill this gap, a bioinformatics analysis of STAT family was carried out in rice. A single STAT-like member OsSTATL was identified. Interestingly, in silico promoter analysis showed a possible regulation of OsSTATL in response to abiotic as well as biotic stresses. Analysis of publically available rice transcriptome data revealed upregulation of expression of OsSTATL gene under drought, salinity and phosphorus deficiency. qRT-PCR based expression analysis showed its heat inducibility in IR64 rice seedlings at an early duration. Moreover, important rice diseases (caused by planthopper and bacterial pathovar) also induce its expression. Protein–protein interaction analysis indicated its interactions with a receptor-like kinase, a transcriptional regulator and chromatin remodeling proteins. OsSTATL protein was found to contain the SH2 (Src homology 2) domain which is responsible for mediating protein–protein interactions. OsSTATL shared sequence similarities with its homologs from monocot lineage. Taken together, this is the first study indicating involvement of OsSTATL in stress response that needs further experimental investigations to understand the regulatory function mediated by OsSTATL under stress conditions.
This study discusses a Schiff base chemosensor ((E)-N’-(2-hydroxybenzylidene)isonicotinohydrazide (HISN)), specifically designed for the rapid detection of Cu²⁺ and Ni²⁺ ions in aqueous medium. HISN characterization was conducted using various methods, including FT-IR, HRMS, ¹H NMR, ¹³C NMR, fluorometric techniques, and UV-Visible spectroscopy. In an acetonitrile solution (1 µM, pH = 7.4), HISN exhibited a noticeable and significant color change from colorless to yellow when exposed to Cu²⁺ and Ni²⁺ ions. The UV-visible absorption spectrum of the HISN-Cu²⁺ and HISN-Ni²⁺ complexes displayed both bathochromic (red) and hypsochromic (blue) shifts. Additionally, the presence of Cu²⁺ and Ni²⁺ ions notably increased the fluorescence intensity of HISN. The limits of detection (LOD) and quantification (LOQ) for HISN with respect to Cu²⁺ and Ni²⁺ ions were established. The LOD values are 3.394 × 10− 9 M for Cu²⁺ and 1.646 × 10− 7 M for Ni²⁺, while the corresponding LOQ values are 1.131 × 10− 8 M for Cu²⁺ and 5.487 × 10− 7 M for Ni²⁺. Data analysis from Job’s plot, along with HRMS and FT-IR spectral data, suggested a 1:1 stoichiometric relationship between HISN and both Cu²⁺ and Ni²⁺ ions. Further, the complex formation between HISN-Cu2+ and HISN-Ni2+ was confirmed by Density Functional Theory (DFT) calculations using Gaussian 16 software. Geometry optimization of these complexes is carried out using the exchange-correlation functional B3PW91 and the basis set 6-311 + G(d, p). MTT assay results indicated that HISN formulations are cytocompatible and do not harm cells at varying concentrations. Furthermore, HISN has been utilized as a fluorescent imaging probe for intracellular Cu²⁺and Ni²⁺ ions.
This work examines the influence of a heat source/sink and dissipation on the MHD laminar flow of Williamson fluid over a nonlinear elastic sheet in a porous medium. The effects of non-linear radiation and Joule heating are also considered. The fluid's conductivity and viscosity are assumed to vary with temperature, enabling the study of heat and mass transfer phenomena. Suitable similarity variables are employed to transfer the resultant system of PDEs into a system of non-linear ODEs. The system is numerically solved utilizing the shooting approach in combination with the 4th-order Runge-Kutta method in MATLAB. The findings are validated through comparison with prior research, demonstrating a high level of agreement. The influence of various flow parameters on heat distribution and the flow field is analyzed and illustrated through diagrams. Additionally, the friction coefficient and Nusselt number are computed numerically for a range of selected parameters and presented in tables. Key findings reveal that the velocity profile decreases with an increase in the viscosity parameter, while temperature rises with a higher viscosity parameter. Moreover, the Nusselt number decreases with an increase in the Williamson, viscosity, and Eckert parameters, while it increased with the suction parameter. The findings may have significant applications in various industrial and scientific fields, particularly in paints and coating, oil drilling, and blood circulation.
In this manuscript, we report a new series of palladium(II)-based macrocyclic complexes synthesized via template condensation of isatin or its derivatives i.e., 5-bromoisatin and 5-chloroisatin with 1,13-diamino-4,7,10-trioxatridecane in the presence of [Pd(OAc)2]3 salt as the metal template. The structural characterization of these complexes has performed using elemental analysis, UV–Vis, FTIR, NMR, and mass spectrometry, confirming their structural integrity and composition. The X-ray diffraction (XRD) patterns confirmed the non-crystalline nature of all the reported complexes. These complexes were evaluated for their biological activity. Antidiabetic activity was observed in preliminary screening. Antioxidant potential was assessed using the DPPH free-radical scavenging assay, where the complexes showed moderate activity. Anticancer activity was examined against MCF-7 human breast adenocarcinoma cell lines using the MTT assay (Averin Biotech, Hyderabad), and the complexes exhibited cytotoxic effects under the tested conditions. Overall, these preliminary findings suggest that the complexes merit further investigation to explore their potential in diverse biological applications.
This study investigates dust acoustic (DA) supersolitary waves in unmagnetized dusty plasma comprising warm positive ions, cold negatively charged mobile dust grains, and nonthermal electrons modelled by the Cairns distribution. The Sagdeev pseudopotential technique is employed to derive the energy balance equation, which satisfies the necessary boundary conditions for the existence of solitons, double layers, and supersolitons. Supersolitons are shown to differ significantly from standard solitons, particularly in the structure of their associated electric fields, which deviate from the typical bipolar form. The corresponding phase trajectories of supersolitons are also explored and found to differ from the traditional homoclinic orbits associated with standard solitons. The analysis reveals that various plasma parameters critically influence the formation and characteristics of these nonlinear structures. Both positive and negative amplitude solitons are possible, while double layers and supersolitons are found to exist only with negative amplitudes for specific sets of plasma parameters. The dust grains charging effect on the existence of supersolitary waves in dusty plasma are also investigated numerically. A comprehensive discussion is presented on the parameter regimes that permit the existence of solitons, supersolitons, and double layers, detailing their permissible ranges in terms of propagation speed, amplitude, and width. This investigation is particularly relevant to space plasma environments where three-component dusty plasmas are present. The findings contribute to a deeper understanding of nonlinear wave phenomena in such plasma systems.
