Star clusters are key components of galaxies, and the relationship between cluster radius and mass encodes information about cluster formation and evolution. Theoretical models predict that age and specific star formation rate (sSFR) should influence cluster size through stellar mass loss and gas dynamics during formation. We hypothesized that if these theoretical predictions hold, multivariate models including age and sSFR should predict cluster radius better than models using mass alone. To test this, we used regression analysis on 5,105 star clusters from the LEGUS survey, comparing a full multivariate model against a mass-only baseline. We found that mass dominated the radius-mass relation: log(Mass) showed a strong correlation with radius (coefficient = 0.131 +/- 0.008, p < 0.001), while log(sSFR) and log(Age) contributed negligibly (0.0002 +/- 0.015 and 0.038 +/- 0.006, respectively). Cross-validation revealed that the mass-only model generalized better (CV R^2 = 0.028 vs -0.017), with the negative value for the multivariate model indicating overfitting. Contrary to our hypothesis, adding age and sSFR did not improve predictive performance. The low R^2 (0.115) indicated that most variance in cluster radius remained unexplained by these variables, suggesting other factors may play important roles. Among the variables tested, our findings were consistent with virial equilibrium predictions, with mass serving as a more fundamental parameter than evolutionary age or galaxy star formation rate.
Scholars reconstruct the tradition history of the temple prophecies in Mark 13:2, 14 par.; 14:58 par.; Q 13:34-35; and Luke 19:41-44; 21:20-24; 23:27-31 in various ways. Cognitive dissonance theory provides a useful guide in constructing the sayings' tradition history, and it suggests a sequence of responses addressing a perceived threat of disconfirmation beginning with Mark 14:58. Additionally, our findings are situated in a social memory framework. Our interdisciplinary methodology and its results are consistent with either scientific realism or social phenomenalism, so disagreement over the historicity of Jesus's prophecy, whether it is historical, false, etc., can ultimately be set aside in the study of these temple prophecies in early Christianity.
Habitat distributions of many coastal species are expected to shift with climate change and sea level rise, affecting local resource use and biotic interactions. Intertidal zones of sandy beaches support a diversity of highly mobile invertebrates that move frequently to adjust to changing tides as well as habitat availability and condition. Many of these species rely on allochthonous inputs of marine macrophytes, or wrack, for food and shelter. We evaluated the effects of habitat availability and resources on spatial niche partitioning by macroinvertebrate detritivores and predators using field surveys and a field experiment on wrack colonization and consumption. Semi-lunar tide phase greatly affected the amount of suitable habitat (54 % more on spring tide) and the mean position of wrack subsidies on the beach (34 % more landward). Predator and detritivore distributions overlapped, but predators were concentrated higher on the beach. From neap to spring tide, the mean intertidal positions of wrack detritivores expanded more (biomass 49.8 %; abundance 45.4 %) than predator positions. In the experiment, significantly more kelp wrack, Egregia menziesii and Macrocystis pyrifera, was consumed than seagrass wrack, Phyllospadix torreyi, at all intertidal levels. Wrack-associated invertebrate community composition differed among wrack types and intertidal levels. Our findings demonstrate how highly mobile intertidal macroinvertebrates partition beach habitat and food resources, with notable spatial separation between detritivores and predators, and how this behavior can be mediated by tide phase and wrack type and position. Linking spatial dynamics of mobile intertidal animals to future projections of habitat availability and resource supply can inform management of sandy beaches with relevance for their conservation as ecosystems in the face of global change.
This study investigates the electrical and antibacterial properties of cobalt ferrite (CoFe2O4) nickel-doped cobalt ferrite (NixCo1-xFe2O4) and lithium-doped cobalt ferrite (LixCo1-x/2Fe2O4) where x = 0.5 synthesized via sol-gel technique using Allium sativum extract (green route) and citric acid (chemical route). The synthesized nanoparticles were characterized by XRD, SEM, EDS and FTIR to analyze their structural and morphological properties. The XRD analysis confirmed that Ni0.5Co0.5Fe2O4, Li0.5Co0.75Fe2O4 and CoFe2O4 compounds are well-crystallized and adopt a cubic spinel structure. The SEM images show distinct morphological changes between the variation of materials synthesis namely, chemically synthesized nanoparticles exhibit well-structured cubic phase, whereas green-synthesized nanoparticles display encapsulated and some irregular morphologies, probably due to the capping effect of the bioactive compound A. sativum extract used as chelating agent. The study on EDS confirmed the presence of all expected constituent elements in their stoichiometric ratios, verifying the successful synthesis of ferrite nanoparticles in the pure form. The analysis of synthesized samples through impedance spectroscopy confirmed that the green synthesis has lower bulk resistance and enhanced electrical conductivity comparative to chemically synthesized compounds. Among all compositions, Ni-doped cobalt ferrite (sol-gel route) exhibited the highest electrical conductivity, while green-synthesized Li0.5Co0.75Fe2O4 showed promising electrochemical behaviour, indicating its potential as an efficient anode material for lithium-ion batteries. Moreover, the antibacterial examines against both Gram-positive and Gram-negative bacterial strains confirmed that the green-synthesized nanoparticles demonstrate a significant and greater antimicrobial activity across all compounds. Therefore, this study highlights the benefits of plant-mediated green synthesis as a sustainable and effective alternative to conventional sol-gel techniques for fabricating multifunctional ferrite nanomaterials with improved electrical and antibacterial routine.
Castration resistant prostate cancer (CRPC) is an aggressive, highly plastic, late-stage disease. We previously showed that the two histological subtypes, adenocarcinoma (CRPC-Adeno) and neuroendocrine (CRPC-NE), show four epigenetic and transcriptomic subtypes: CRPC-AR depends on the androgen receptor pathway, CRPC-SCL is stem-cell like, CRPC-WNT is dependent on the WNT pathway, and CRPC-NE has high expression of neuroendocrine markers. Here, by analyzing data from 500 patients with tissue and/or liquid biopsies, we uncover the landscape of molecular heterogeneity in patient tumors. Analysis of whole-genome sequencing revealed genomic variants associated with CRPC-SCL and allowed development of a computational classifier which can predict presence of CRPC-SCL in patient tumors solely using genomic alterations with 81% accuracy. In particular, analysis of matched chromatin conformation data (Hi-C) showed a complex rearrangement on chromosome 4 disrupts enhancer - promoter contacts leading to downregulation of MOB1B, which can lead to upregulation of the YAP/TAZ pathway that is characteristic of CRPC-SCL. Joint computational inference of epigenomic state and genomic variants from cell-free DNA collected at multiple points during the evolution of resistance to AR signaling inhibitors allowed investigation of genomic and epigenomic co-evolution at an unprecedented resolution. We discuss the current limits of detection for tumoral epigenomic and genomic states using cell-free DNA for clinical application. Importantly, our study demonstrates the utility of liquid biopsies for discovery of basic biological mechanisms leading to treatment resistance, beyond their use for biomarkers. Marjorie Roskes, Alexander Martinez-Fundichely, Weiling Li, Sandra Cohen, Hao Xu, Shahd ElNaggar, Anisha Tehim, Metin Balabin, Chen Khuan Wong, Yu Chen, Ben Raphael, Ekta Khurana. Evolution of genomic and epigenomic heterogeneity in prostate cancer from tissue and liquid biopsies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3883.
