This study aimed to evaluate the impact of metastatic lymph nodes (LNs) outside the extended pelvic lymph node dissection (ePLND) template on oncological outcomes, staging, grading, and concomitant parameters in prostate cancer (PCa) patients undergoing radical prostatectomy (RP). Data from 860 patients with histologically confirmed, non-metastatic PCa who underwent RP between 2012 and 2022 were retrospectively analyzed. All specimens underwent detailed histopathological examination. Preoperative and postoperative clinicopathological data were collected and analyzed. Subgroup associations were evaluated using the Mann–Whitney U test and the Kruskal–Wallis test. Kendall’s tau-b coefficient was employed to evaluate the association between two variables. All tests were performed using a two-tailed approach, with a p value of less than 0.05 considered statistically significant for differences between groups. Kaplan–Meier and Cox regression analyses assessed biochemical recurrence (BCR)-free survival based on lymph node invasion (LNI) (pN0 vs. pN1) and the presence of metastatic LNs outside the ePLND template. Of the 860 patients, 613 underwent modified-ePLND. Among them, 122 (19.9
Background: Prostate cancer is the second most common malignant cancer among men, and according to the predictions, the estimated number of new cases will substantially grow in the coming years. Therefore, the costs of the disease will increase as well. Methods: We conducted a literature review of the state of knowledge about the costs of treatment and the economic burden of prostate cancer. The vast majority of studies were focused on direct costs only, which clearly shows the literature gap. Results: We focused on the estimates of direct costs, i.e., treatment of prostate cancer, adjuvant and neoadjuvant treatment, and supportive and palliative care, and indirect costs. Cost-effectiveness analyses indicated that docetaxel combined with androgen deprivation therapy (ADT) was the most cost-effective strategy for metastatic hormone-sensitive prostate cancer (incremental cost-effectiveness ratio (ICER): USD 13,647). In contrast, novel therapies such as PARP inhibitors and whole-genome-sequencing-guided treatments were not cost-effective unless drug prices were reduced by 47–70%. In the United States, 5-year cumulative treatment costs ranged from USD 48,000 for conservative management to over USD 91,000 for radiotherapy, while out-of-pocket expenses averaged AUD 1172 in Australia. Indirect costs were also considerable, with Slovakia reporting an increase in sick leave costs from EUR 1.2 million in 2014 to EUR 2.1 million in 2022. Conclusions: Metastatic hormone-sensitive prostate cancer and metastatic castration-resistant prostate cancer were the most frequent categories for various treatment cost evaluations. A few specific combinations of drugs were cost-effective only under the condition of dropping the unit prices of a medication. Further summarizing, reviewing, and developing a methodology for standardized comparisons are needed.
This paper is an overview of many researchers’ opinions on the presence of a religious element in La Plata’s literature. The perspective of the article is definitely diachronic, critical and analytical. According to the conclusions of the literature researchers, there is a strict relationship between theological thinking and the current social and cultural issues and the ideological layer of particular literary works. A novelty in our study is that what is seemingly absent from the religious subject area can function as a visible sign of theological thinking in La Plata’s work. Even anticlerical attitudes may be indicating a religious background of their authors. Almost no literary work of La Plata may be considered as devoid of theological motifs or inspiration.
Lung cancer is the leading cause of death among all the oncological diseases worldwide. This applies to both women and men; however, the incidence and mortality among women is on the rise. In 2020, lung cancer was responsible for 1.8 million deaths (18%). More than 90% of lung cancer cases and 77.1% of lung cancer deaths occur in countries with high and very high HDI (human development index) values. The aim of our study is to the present trends and most recent studies aimed at lung cancer screening. In the face of the persistently high mortality rate, conducting research aimed at extending already-implemented diagnostic algorithms and behavioural interventions focused on smoking cessation is recommended.
Pro-environmental behaviors foster hotel sustainability, including the achievement of environmental goals. The willingness to pay more for sustainable hotel services should be considered a key pro-environmental behavior. The purpose of this study is to identify the relationship between hotel guests' willingness to pay more for sustainable services in regard to their pro-environmental behavior and selected socioeconomic characteristics. Two main research methods were used: a systematic literature review and a diagnostic survey. A total of 1317 questionnaires were collected from guests of six Polish hotels. The relationship between guests' willingness to pay more for sustainable hotel services and their environmental beliefs was observed. Relationships (positive and negative) between pro-environmental (mitigating) behaviors and willingness to pay higher costs for sustainable services were also noted. Moreover, guests with a higher financial status and education as well as younger guests were found to be more likely to accept higher prices for sustainable hotel services.
