Biotechnology (Reading, Mass.)

This chapter contains sections titled: Introduction Enzymes for the Pulp and Paper Industry Enzymes as Process Aids Enzymes for Product Design Biorefinery Concepts Conclusions References

This chapter contains sections titled: Introduction The Graphical System Conclusions and Open Issues References

Chapter 4 Genomics and Human Disease Roger C. Green, Roger C. Green St. John's, CanadaSearch for more papers by this author Roger C. Green, Roger C. Green St. John's, CanadaSearch for more papers by this author Book Editor(s):Prof. Dr. H. J. Rehm, Prof. Dr. H. J. Rehm Institut für Mikrobiologie Universität Münster Corrensstraße 3 D-48149 Münster FRGSearch for more papers by this authorDr. G. Reed, Dr. G. Reed 1029 N. Jackson St. #501-A, Milwaukee, WI 53202-3226 USASearch for more papers by this author First published: 25 April 2001 https://doi.org/10.1002/9783527620876.ch4 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary This chapter contains sections titled: Introduction Identification of Disease-Associated Genes Diagnostics and Genetic Testing Treatment Conclusions References References Allen. R. L., et al. 1999, The role of HLA-B27 in spondyloarthritis, Immunogenetics 50: 220—227. 10.1007/s002510050596 CASPubMedWeb of Science®Google Scholar Annas. G. J., 2000, Rules for research on human genetic variation-lessons from Iceland, N. Engl. J. Med. 342: 1830—1833. 10.1056/NEJM200006153422412 CASPubMedWeb of Science®Google Scholar Anonymous 1995, Positional Cloning Approach Expedites Gene Hunts, Human Genome News 6: 1. Google Scholar Aparicio, S.A. 2000, How to count human genes. Nature Genet. 25: 129—130. 10.1038/75949 CASPubMedWeb of Science®Google Scholar Botstein. D., 1999. Of genes and genomes, Ann. N.Y. Acad. Sci. 882: 32—41. 10.1111/j.1749-6632.1999.tb08531.x CASPubMedWeb of Science®Google Scholar Bradley, B.A., Evers, B.M. 1997, Molecular advances in the etiology and treatment of colorectal cancer, Surg. Oncol. 6: 143—156. 10.1016/S0960-7404(97)00020-0 CASPubMedWeb of Science®Google Scholar Buckley, R.H. 2000, Gene therapy for human SCID: Dreams become reality, Nature Med. 6: 623—624. 10.1038/76185 CASPubMedWeb of Science®Google Scholar Cambien, E, et al. 1992, Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction, Nature 359: 641—644. 10.1038/359641a0 CASPubMedWeb of Science®Google Scholar Cavazzana-Calvo, M., et al. 2000, Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease, Science 288: 669—672. 10.1126/science.288.5466.669 CASPubMedWeb of Science®Google Scholar Collins. F. S., et al. 1997, Variations on a theme: cataloging human DNA sequence variation, Science 278: 1580—1581. 10.1126/science.278.5343.1580 CASPubMedWeb of Science®Google Scholar Corder, E.H. et al. 1993, Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families, Science 261: 921—923. 10.1126/science.8346443 CASPubMedWeb of Science®Google Scholar Cotton, R.G. H. 1997, Mutation Detection. Oxford: Oxford University Press. Google Scholar De Braekeleer, M. 1991, Hereditary disorders in Saguenay-Lac-St.-Jean (Quebec, Canada), Hum. Hered. 41: 141—146. 10.1159/000153992 CASPubMedWeb of Science®Google Scholar De La Chapelle, A. 1993, Disease gene mapping in isolated human populations: the example of Finland. J. Med. Genet. 30: 857—865. 10.1136/jmg.30.10.857 PubMedWeb of Science®Google Scholar De Vos, A., et al. 1998, Pregnancy after preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1 A, Mol. Hum. Reprod. 4: 978—984. 10.1093/molehr/4.10.978 CASPubMedWeb of Science®Google Scholar Enlund, F., et al. 1999, Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden, Eur. J. Hum. Genet. 7: 783—790. 10.1038/sj.ejhg.5200365 CASPubMedWeb of Science®Google Scholar Evans, W.E., Relling, M.V. 1999, Pharmacogenomics: translating functional genomics into rational therapeutics, Science 286: 487—491. 10.1126/science.286.5439.487 CASPubMedWeb of Science®Google Scholar Ewing, B., Green, P. 2000, Analysis of expressed sequence tags indicates 35,000 human genes, Nature Genet. 25: 232—234. 10.1038/76115 CASPubMedWeb of Science®Google Scholar Grann, V.R. et al. 2000, Prevention with tamoxifen or other hormones versus prophylactic surgery in BRCAl/2-positive women: a decision analysis, Cancer J. Sci. Am. 6: 13—20. CASPubMedWeb of Science®Google Scholar Gusella, J.E., et al. 1983, A polymorphic DNA marker genetically linked to Huntington’s disease, Nature 306: 234—238. 10.1038/306234a0 CASPubMedWeb of Science®Google Scholar Hacia, J. G, 1999, Resequencing and mutational analysis using oligonucleotide microarrays, Nature Genet. 21: 42—47. 10.1038/4469 CASPubMedWeb of Science®Google Scholar Hanis, C.L. et al. 1996, A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2, Nature Genet. 13: 161—166. 10.1038/ng0696-161 CASPubMedWeb of Science®Google Scholar Helgason, A., et al. 2000, mtDNA and the origin of the Icelanders: deciphering signals of recent population history, Am. J. Hum. Genet. 66: 999—1016. 10.1086/302816 CASPubMedWeb of Science®Google Scholar Heyer, E., et al. 1997, Seventeenth-century European origins of hereditary diseases in the Saguenay population (Quebec, Canada), Hum. Biol. 69: 209—225. CASPubMedWeb of Science®Google Scholar Hudson, T.J. et al. 1995, An STS-based map of the human genome, Sience 270: 1945—1954. 10.1126/science.270.5244.1945 CASPubMedWeb of Science®Google Scholar Hurme, M., et al. 1998, Gene polymorphisms of interleukins 1 and 10 in infectious and autoimmune diseases, Ann. Med. 30: 469—473. 10.3109/07853899809002488 CASPubMedWeb of Science®Google Scholar Ikeda M. Yu, D.T. 1998, The pathogenesis of HLA-B27 arthritis: role of HLA-B27 in bacterial defense, Am. J. Med. Sci. 316: 257—263. 10.1097/00000441-199810000-00006 CASPubMedWeb of Science®Google Scholar Ingram, V.M. 1959, Abnormal human haemoglobin. III. The chemical difference between normal and sickle cell haemoglobins, Biochim. Biophys. Acta 36: 402—411. 10.1016/0006-3002(59)90183-0 CASPubMedWeb of Science®Google Scholar Jeunemaitre, X., et al. 1992, Molecular basis of human hypertension: role of angiotensinogen, Cell 71: 169—180. 10.1016/0092-8674(92)90275-H CASPubMedWeb of Science®Google Scholar Kronn, D., et al. 1998, Carrier screening for cystic fibrosis, Gaucher disease, and Tay-Sachs disease in the Ashkenazi Jewish population: the first 1000 cases at New York University Medical Center, New York, NY, Arch. Intern. Med. 158: 777—781. 10.1001/archinte.158.7.777 CASPubMedWeb of Science®Google Scholar Kuliev, A., et al. 1999, Birth of healthy children after preimplantation diagnosis of thalassemias, J. Assist. Reprod. Genet. 16: 207—211. 10.1023/A:1020316924064 CASPubMedWeb of Science®Google Scholar Kurg, A., et al. 2000, Arrayed primer extension: solid-phase four-color DNA resequencing and mutation detection technology, Genet. Test. 4: 1—7. 10.1089/109065700316408 CASPubMedWeb of Science®Google Scholar Lathrop, G.M. et al. 1985, Multilocus linkage analysis in humans: detection of linkage and estimation of recombinations, Am. J. Hum. Genet. 37: 482—498. PubMedWeb of Science®Google Scholar Liang, E, et al. 2000, Gene index analysis of the human genome estimates approximately 120,000 genes, Nature Genet. 25: 239—240. 10.1038/76126 CASPubMedWeb of Science®Google Scholar Lynch, H.T. et al. 1999, Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer: Part II: Hereditary nonpolyposis colorectal carcinoma as a model, Cancer 86: 2457—2463. 10.1002/(SICI)1097-0142(19991201)86:11+<2457::AID-CNCR2>3.0.CO;2-I CASPubMedWeb of Science®Google Scholar Mathew, C.G. 1999, DNA diagnostics: goals and challenges, Br. Med. Bull. 55: 325—339. 10.1258/0007142991902402 CASPubMedWeb of Science®Google Scholar Mckusick, V.A. (Ed.) 1966, Mendelian Inheritance in Man. Baltimore, MD: Johns Hopkins University Press. Google Scholar Nyholt, D.R. et al. 1998a, Familial typical migraine: linkage to chromosome 19pl3 and evidence for genetic heterogeneity, Neurology 50: 1428—1432. 10.1212/WNL.50.5.1428 CASPubMedWeb of Science®Google Scholar Nyholt, D.R. et al. 1998b, Evidence for an X-linked genetic component in familial typical migraine, Hum. Mol. Genet. 7: 459—463. 10.1093/hmg/7.3.459 CASPubMedWeb of Science®Google Scholar Palu, G., et al. 1999, In pursuit of new developments for gene therapy of human diseases, J. Biotechnol. 68: 1—13. 10.1016/S0168-1656(98)00134-5 CASPubMedWeb of Science®Google Scholar Parens, E. 1996, Glad and terrified: On the ethics of BRCA1 and 2 testing, Cancer Invest. 14: 405—411. 10.3109/07357909609012169 CASPubMedWeb of Science®Google Scholar Peltonen, L. 2000, Positional cloning of disease genes: advantages of genetic isolates, Hum. Hered. 50: 66—75. 10.1159/000022892 CASPubMedWeb of Science®Google Scholar Petersen, G.M. et al. 1999, Genetic testing and counseling for hereditary forms of colorectal cancer, Cancer 86: 2540—2550. 10.1002/(SICI)1097-0142(19991201)86:11+<2540::AID-CNCR11>3.0.CO;2-8 CASPubMedWeb of Science®Google Scholar Pile, K.D. 1999, Broadsheet number 51: HLA and disease associations, Pathology 31: 202—212. 10.1080/003130299104972 CASPubMedWeb of Science®Google Scholar Risch, N.J. 2000, Searching for genetic determinants in the new millennium, Nature 405: 847—856. 10.1038/35015718 CASPubMedWeb of Science®Google Scholar Risch N. Merikangas, K. 1996, The future of genetic studies of complex human diseases, Science 273: 1516—1517. 10.1126/science.273.5281.1516 CASPubMedWeb of Science®Google Scholar Roger, M. 1998, Influence of host genes on HIV-1 disease progression, FASEB J. 12, 625—632. 10.1096/fasebj.12.9.625 CASPubMedWeb of Science®Google Scholar Roses, A.D. 1997, A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease, Neurogenetics 1: 3—11. 10.1007/s100480050001 CASPubMedWeb of Science®Google Scholar Roses, A.D. 2000, Pharmacogenetics and the practice of medicine, Nature 405: 857—865. 10.1038/35015728 CASPubMedWeb of Science®Google Scholar Ruschoff, J., et al. 1998, Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection, Proc. Natl. Acad. Sci. USA 95: 11301—11306. 10.1073/pnas.95.19.11301 CASPubMedWeb of Science®Google Scholar Seamark, C.J., Hutchinson, M. 2000, Controversy in primary care. Should asymptomatic haemochromatosis be treated? Br. Med. J. 320: 1314—1317. 10.1136/bmj.320.7245.1314 CASPubMedWeb of Science®Google Scholar Service, S.K. et al. 1999, Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations. Am. J. Hum. Genet. 64: 1728—1738. 10.1086/302398 CASPubMedWeb of Science®Google Scholar Shaw, J.T. et al. 1998, Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q. Diabetes 47: 1793—1796. 10.2337/diabetes.47.11.1793 CASPubMedWeb of Science®Google Scholar Sheffield, V.C. et al. 1998. Use of isolated inbred human populations for identification of disease genes, Trends Genet. 14: 391—396. 10.1016/S0168-9525(98)01556-X CASPubMedWeb of Science®Google Scholar Smith. A. E., 1999. Gene therapy-where are we? Lancet 354 (Suppl. 1). SI1—SI4. 10.1016/S0140-6736(99)90240-4 PubMedWeb of Science®Google Scholar Syngal. S., et al. 1999, Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing, JAMA 282: 247—253. 10.1001/jama.282.3.247 CASPubMedWeb of Science®Google Scholar Syvanen. A. C., 1999. From gels to chips: “minisequencing” primer extension for analysis of point mutations and single nucleotide polymorphisms, Hum. Mut. 13. 1—10. 10.1002/(SICI)1098-1004(1999)13:1<1::AID-HUMU1>3.0.CO;2-I CASPubMedWeb of Science®Google Scholar Taillon-Miller, P., et al. 1999, Efficient approach to unique single-nucleotide polymorphism discovery, Genome Res. 9: 499—505. CASPubMedWeb of Science®Google Scholar The Huntington’s Disease Collaborative Research Group 1993, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes, Cell 72: 971—983. 10.1016/0092-8674(93)90585-E PubMedWeb of Science®Google Scholar Thorsby, E. 1997, Invited anniversary review: HLA associated diseases, Hum. Immunol. 53: 1—11. 10.1016/S0198-8859(97)00024-4 CASPubMedWeb of Science®Google Scholar Tonisson, N., et al. 2000, Unravelling genetic data by arrayed primer extension, Clin. Chem. Lab. Med. 38: 165—170. 10.1515/CCLM.2000.025 CASPubMedWeb of Science®Google Scholar Van Ommen, G.J. et al. 1999, The human genome project and the future of diagnostics, treatment, and prevention, Lancet 354, (Suppl. 1), SI5—10. 10.1016/S0140-6736(99)90241-6 PubMedWeb of Science®Google Scholar Wang. J. H., Hewick, R.M. 1999, Proteomics in drug discovery, Drug Discov. Today 4: 129—133. 10.1016/S1359-6446(99)01306-9 PubMedWeb of Science®Google Scholar Biotechnology: B: Genomics and Bioinformatics, Volume 5, Second Edition ReferencesRelatedInformation

Chapter 16 Biotechnology in Plant Protection Frank Niepold, Frank Niepold Braunschweig, GermanySearch for more papers by this authorKlaus Rudolph, Klaus Rudolph Göttingen, GermanySearch for more papers by this author Frank Niepold, Frank Niepold Braunschweig, GermanySearch for more papers by this authorKlaus Rudolph, Klaus Rudolph Göttingen, GermanySearch for more papers by this author Book Editor(s):Prof. Dr. H.-J. Rehm, Prof. Dr. H.-J. Rehm Institut für Mikrobiologie, Universität, Münster, Corrensstraße 3, D-48149 Münster, FRGSearch for more papers by this authorDr. G. Reed, Dr. G. Reed 1029 N. Jackson St.,#501-A, Milwaukee, WI 53202-3226, USASearch for more papers by this author First published: 05 October 2001 https://doi.org/10.1002/9783527620937.ch16Citations: 2 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary The prelims comprise: Introduction Biocontrol of Plant Pathogens or Weeds by Living Organisms Plants Transformed with Bacterial, Fungal or Non-Indigenous Genes Reducing Diseases Caused by Fungi or Bacteria Virus Resistant Plants Antibodies Produced in Plants as Plant Protection Products Herbicide Resistant Crops Mechanisms of Plants for Protection against Pathogen Attack by “Systemic Acquired Resistance” Use of Beneficial Arthropods and Sterile Insect Release Insect Pathogenic Microorganisms Pheromones Serology and DNA Procedures as Detection Tools Biotechnologically Produced Plant Protection Products Authorized in Germany Discussion and Outlook Citing Literature Biotechnology: Special Processes, Volume 10, Second Edition RelatedInformation

Chapter 15 Structure Information Miroslaw Cygler, Miroslaw Cygler Montreal, CanadaSearch for more papers by this authorAllan Matte, Allan Matte Montreal, CanadaSearch for more papers by this authorJoseph D. Schrag, Joseph D. Schrag Montreal, CanadaSearch for more papers by this author Miroslaw Cygler, Miroslaw Cygler Montreal, CanadaSearch for more papers by this authorAllan Matte, Allan Matte Montreal, CanadaSearch for more papers by this authorJoseph D. Schrag, Joseph D. Schrag Montreal, CanadaSearch for more papers by this author Book Editor(s):Prof. Dr. H. J. Rehm, Prof. Dr. H. J. Rehm Institut für Mikrobiologie Universität Münster Corrensstraße 3 D-48149 Münster FRGSearch for more papers by this authorDr. G. Reed, Dr. G. Reed 1029 N. Jackson St. #501-A, Milwaukee, WI 53202-3226 USASearch for more papers by this author First published: 25 April 2001 https://doi.org/10.1002/9783527620876.ch15 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary This chapter contains sections titled: Introduction Protein Fold Evolution and Three-Dimensional Structure Structure to Function, Structural Signatures Homology Modeling Fold Recognition by Threading Virtual Screening Molecular Machines De nevo Protein Design References Biotechnology: B: Genomics and Bioinformatics, Volume 5, Second Edition RelatedInformation

This chapter contains sections titled: Introduction The Process of Genome Annotation Genome Annotation Examples Conclusions References

This chapter contains sections titled: Introduction Types of Genetic Research Research Ethics "Genethics" DNA Banking Ownership Conclusion References

This chapter contains sections titled: Introduction Overview of Sanger Dideoxy Sequencing Fluorescence Dye Chemistry Biochemistry of DNA Sequencing Fluorescence DNA Sequencing Instrumentation DNA Sequence Analysis References

Chapter 15 Marine Biotechnology Ulrike Lindequist, Ulrike Lindequist Greifswald, GermanySearch for more papers by this authorThomas Schweder, Thomas Schweder Greifswald, GermanySearch for more papers by this author Ulrike Lindequist, Ulrike Lindequist Greifswald, GermanySearch for more papers by this authorThomas Schweder, Thomas Schweder Greifswald, GermanySearch for more papers by this author Book Editor(s):Prof. Dr. H.-J. Rehm, Prof. Dr. H.-J. Rehm Institut für Mikrobiologie, Universität, Münster, Corrensstraße 3, D-48149 Münster, FRGSearch for more papers by this authorDr. G. Reed, Dr. G. Reed 1029 N. Jackson St.,#501-A, Milwaukee, WI 53202-3226, USASearch for more papers by this author First published: 05 October 2001 https://doi.org/10.1002/9783527620937.ch15 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary The prelims comprise: Introduction Marine Diversity Marine Organisms of Biotechnological Potential Production Processes Products of Marine Biotechnology Bioremediation with Marine Microorganisms Hydrogen Production Outlook Biotechnology: Special Processes, Volume 10, Second Edition RelatedInformation

Chapter 11 Vitamins and Related Compounds: Microbial Production Sakayu Shimizu, Sakayu Shimizu Kyoto, JapanSearch for more papers by this author Sakayu Shimizu, Sakayu Shimizu Kyoto, JapanSearch for more papers by this author Book Editor(s):Prof. Dr. H.-J. Rehm, Prof. Dr. H.-J. Rehm Institut für Mikrobiologie, Universität, Münster, Corrensstraße 3, D-48149 Münster, FRGSearch for more papers by this authorDr. G. Reed, Dr. G. Reed 1029 N. Jackson St.,#501-A, Milwaukee, WI 53202-3226, USASearch for more papers by this author First published: 05 October 2001 https://doi.org/10.1002/9783527620937.ch11Citations: 4 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary The prelims comprise: Introduction Water-Soluble Vitamins Fat-Soluble Vitamins Concluding Remarks Citing Literature Biotechnology: Special Processes, Volume 10, Second Edition RelatedInformation

This chapter contains sections titled: Introduction Genome Projects of Selected Prokaryotic Model Organisms Genome Projects of Selected Eukaryotic Model Organisms Conclusions References

The prelims comprise: Introduction History of Biodeterioration Microorganisms Microbial Growth Selected Metabolic Circles Overview of Microbial Deterioration Mechanisms Countermeasures for Microbial Growth Biofilm—Biofouling Biocorrosion of Metals Biodeterioration of Mineral Materials Biodeterioration of Organic Materials Useful Biodeterioration Synopsis Further Reading

This chapter contains sections titled: Introduction Genome Mapping Positional Cloning Comparative Approaches to Gene Identification References

This chapter contains sections titled: Introduction Capillary Electrophoresis Capillary Electrophoresis for Protein Analysis Single-Cell Analysis Two-Dimensional Separations Conclusions References

This chapter contains sections titled: Introduction Variations on Established Procedures Membrane Procedures in Biological Waste Gas Purification Conclusions References

This chapter contains sections titled: Differentiating Sanitation Systems -The Basic Step to Resources Management A Pilot Project for Vacuum Biogas Systems in Urban Areas Further Options for Integrated Sanitation Concepts Based on Biogas Plants References

This chapter contains sections titled: Objectives Influencing Factors Composting Systems Compost Quality and End Uses References