Evidence on long-acting cabotegravir plus rilpivirine (CAB + RPV LA) in older people with HIV (PWH) remains limited. We evaluated virological outcomes, treatment persistence and injection-schedule adherence by age. This nationwide ambispective RELATIVITY cohort analysis compared virologically suppressed adults aged ≥ 60 and < 60 years who initiated CAB + RPV LA by 31 December 2024. Persistence was assessed using Kaplan–Meier estimates and multivariable Cox regression, including an exploratory age-by-comorbidity interaction. Among 3,349 participants at 53 centers, 407 (12.2
Menopause is associated with functional decline, but evidence linking menopausal hormone therapy (MHT) to frailty risk remains limited. To evaluate whether achievement of a prespecified MHT exposure threshold was associated with lower frailty risk among MHT initiators. Using the NHIS-HEALS database (2002–2019), we conducted a nationwide new-user cohort study of 31,294 women aged ≥ 45 years who initiated systemic MHT and were non-frail at baseline, with up to 10 years of follow-up. The outcome was transition to high frailty risk status (Hospital Frailty Risk Score [HFRS] > 15). The target strategy was ≥ 28 cumulative days of MHT within 60 days of initiation. Strategies were compared by clone–censor–weighting within a target trial emulation framework, with doubly robust estimation. Overall, 25,907 participants (82.8
Population ageing is increasing demand for osteoporosis assessment, yet access to dual-energy X-ray absorptiometry (DXA) remains uneven. The Osteoporosis Self-assessment Tool for Asians (OSTA) may help prioritize access. To evaluate OSTA ranking, referral workload, and age-specific detection, with separate hip-fracture follow-up in China. We analyzed women aged 50–79 years in US/Korean DXA surveys and the China Health and Retirement Longitudinal Study (CHARLS). Survey-weighted analyses assessed femoral-neck osteoporosis using a common US T-score reference; 1,000 cluster bootstrap replicates quantified discrimination and referral uncertainty, including paired allocation contrasts. Community-cluster Cox and competing-risk models assessed self-reported hip fracture. External areas under the curve were 0.754–0.831. A US threshold targeting 20
Existing fall risk assessment tools often rely on objective performance tests or clinical diagnoses, limiting their feasibility for large-scale community application. This study examined whether easily obtainable self-reported indicators are independently associated with subsequent falls among middle-aged and older Chinese adults, evaluated heterogeneity across subgroups, and developed a parsimonious nomogram as a community pre-screening aid. Data from four CHARLS waves (2011–2018) were used to identify 46,405 eligible adjacent-wave pairs from 20,364 participants aged ≥ 45 years. We first examined descriptive same-wave associations between visit-level indicators and falls reported for the preceding 12 months, and then fitted lagged GEE models relating indicators and covariates measured at wave T to falls reported in the 12 months before the next visit (T + 1). Association estimates were pooled across 20 multiply imputed datasets using Rubin’s rules. The seven-variable nomogram was developed and internally evaluated in a separate prediction cohort with one eligible interval per participant. Exploratory interactions across candidate subgroups and recorded fall-history groups were assessed with false discovery rate correction. In the descriptive same-wave analysis, all five indicators were associated with falls reported for the preceding 12 months. In the primary lagged analysis, recorded prior falls (OR = 2.540, 95
This investigation carried out a systematic review and network meta-analysis to assess how different forms of mind–body exercise influence overall cognitive performance in patients with MCI. A systematic search was conducted across eight Chinese and English databases (up to April 2026). A frequency-based network meta-analysis was performed to estimate the standardized mean differences and 95
