MONILIAL granuloma is a rare specific disease entity resulting from Candida albicans infection. It begins in infancy or early childhood, often as simple oral thrush, and ultimately involves three sites: the oral mucosa, the finger nails and paronychial tissues and the skin of the scalp and face. The skin of the trunk and extremities is rarely involved. In contrast to the banal superficial forms of moniliasis, such as thrush, perleche, erosio interdigitalis blastomycetica and other intertriginous eruptions, monilial granuloma is characterized by an inflammatory reaction extending into the corium and consisting of granulation tissue similar to that in the deep mycoses. This report is based on observation of 1 case by us, and on reports of 13 cases uncovered in the literature. REPORT OF CASE G. S., a 7 year old white boy, was first seen in February 1948, with the history of "growths" on the skin since the age
THE DERMATOLOGIC literature abounds with reports of leukoplakia buccalis.1Many have written on electrogalvanism in the mouth,2but few3have stated that they have observed cases of leuko-plakia due to electrogalvanism in the mouth. The reports of Hollander, Ullman, Vilanova, Touraine and Baudouin, Lain and Caughron, Fitzwilliams and others who stated that they had studied cases of leukoplakia due to electrogalvanism have not appeared conclusive to us. Only those cases of clinical leukoplakia that were confirmed by a microscopic diagnosis have been considered by us to be true leukoplakia. This requirement eliminated 3 cases of lichen planus limited to the oral cavity and cases that seemed to be more compatible with senile changes than with true sharply marginated leukoplakia. This report is based on 15 cases of leukoplakia. The fact that electrical potential differences between metallic dental restorations exist in the oral
IN THE treatment of epithelioma the "silent" extensions from the main mass of cancer can accurately be followed out and eradicated by means of the multiple, microscopically controlled excisions which characterize the chemosurgical method.1In the treatment of melanoma, however, this microscopic control would seem to be of more limited value because often there is a discontinuous, embolic mode of spread into the peritumoral lymphatics and beyond. The purpose of this article is to attempt to clarify the place of chemosurgery in the treatment of this highly malignant disease through the analysis of a consecutive series of 20 cases of melanoma in patients who have been observed for five or more years or until death. TECHNIC The microscopic control of excision, which is the most important feature of the chemosurgical method, is attained by a process which includes (1) chemical fixation, in situ, of the tissue
IN A DISEASE, such as lupus Erythematosus, for which the etiology is unknown, a great deal of effort becomes directed toward the expansion of knowledge of its hematology, cytology and pathology. It is well not to overlook investigations into the physiologic or functional alterations which occur in this condition, for a clue may come from this direction. The new staining technics have thrown much light on the pathology of lupus erythematosus. They may also indicate what lies behind this pathology. Altschuler and Angevine of the University of Wisconsin 1 and many others expressed the opinion that the essential feature of fibrinoid degeneration is the precipitation of acid mucopolysaccharide. The compound in this group that has been mentioned most frequently in recent medical literature is hyaluronic acid. This is a large and structurally asymmetric compound which is highly viscous even in low concentrations. The aforementioned authors stated the belief that the
THE ARMY Industrial Hygiene Laboratory applied 28,201 test patches to 2,036 volunteer human test subjects during the period March 1948 to April 1949 in the "prophetic" patch testing of various items of military supplies and equipment destined for contact with the skin of personnel of the armed forces. In addition to the standard, cellophane-backed, elastic adhesive patch, known as the Schwartz patch, two other devices, to be described, were tried experimentally for holding the test materials in contact with the skin, in an effort to make the conditions surrounding the testing of an item correspond more closely with conditions surrounding the use of that item. Materials tested included leathers, fabrics and plastics treated with chemicals to render them resistant to mildew, fabrics treated with chemicals to make them resistant to shrinkage, natural and butyl rubbers for gas masks, gauze impregnated with antiseptic solutions and untreated or widely accepted materials to
An article entitled Lupus Erythematosus Profundus (Kaposi-Irgang) by Harry L. Arnold Jr. 1 induces me to call attention again to the symptomatology of lupus erythematosus hypertrophicus et profundus, a disease which, if observed a few times, can never be mistaken for anything else. The clinical picture is uniform, definite and distinctive, as I pointed out in a previous article on the subject. 2 Differential diagnosis from Boeck's sarcoid, angiolupoid and other variants is clinically possible and not at all difficult. The only variation in its clinical picture is in the degree of severity of the lesions. It belongs to the classification of the fixed discoid variety of the disease but differs greatly from this in appearance. A typical example of lupus erythematosus hypertrophicus et profundus is characterized by more or less oval or rounded, rather sharply outlined, greatly elevated plateau-like plaques with indurated, rolled borders and a variation
