WE ARE reporting a case of vitiligo with raised borders because of its rarity and unknown pathogenesis. REPORT OF A CASE A. L.,1a boy aged 12, was admitted for treatment at the Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital on Feb. 25, 1946, presenting depigmented patches of two months' duration. He had scarlet fever, measles, chickenpox and mumps during early childhood and impetigo of the face and eyebrows at the age of 7. There was dry diffuse seborrhea of the scalp but no loss of hair. The patient was sensitive about the appearance of the white patches. There were no subjective symptoms. The lesions were not preceded by tingling or itchy sensations. His general health was unimpaired. A white spot first appeared on the penis. A similar spot developed two weeks later on the forehead; after an interval of two weeks, spots

Folliculitis Ulerythematosa Reticulata.Presented byDr. E. W. Abramowitz. S. R., a woman aged 26, came to the New York Skin and Cancer Hospital on Feb. 10, 1943, with dermatitis venenata of one hand. In addition, she showed an eruption on the cheeks. These areas presented worm-eaten-like pitted scars situated on a mild erythematous base. The patient states that the eruption on her face has been present as long as she can remember. A maternal aunt has a similar condition, but none of the patient's siblings, parents or other relatives are affected. DISCUSSION Dr. George C. Andrews: I agree with the diagnosis. This is a case of mild but definite folliculitis ulerythematosa reticulata. Dr. Paul E. Bechet: I agree with the diagnosis despite the fact that there is no erythema and that only the reticulated atrophy is present. In my experience such a clinical picture is not unusual in the

Our purpose in this paper is to discuss the value of mapharsen in the treatment of syphilis by the physician in his private practice. It is known that the majority of syphilitic patients undergoing treatment in private practice are in the late asymptomatic stage and that the diagnosis of syphilis is frequently made solely on serologic evidence. Now that most states have, or soon will have, legislation requiring routine premarital and antepartum blood tests, many more latent asymptomatic syphilitic persons will be detected and will undergo treatment in clinics or in private practice. It has been estimated that between 50 and 90 per cent of syphilitic patients treated in private practice are asymptomatic. It is especially with regard to this large group that the determination of the diagnosis rests, in large measure, on the outcome of the serologic examination. One of the great difficulties encountered in private practice is to

Under the title "A Case of a Hitherto Undescribed Skin Disease, Epidermodysplasia Verruciformis," Lewandowsky and Lutz 1 in 1922 published an article describing an eruption in a woman aged 29 who had had innumerable and widespread warty growths scattered over the body since early infancy. During the subsequent decade, 22 additional instances of presumably the same disease were recorded in foreign journals. These were collected and discussed by Maschkilleissen 2 in 1931. From that date to the present, 6 more cases have been recorded, of which the first 3 are European and the last 3, including our own, were encountered in the United States. This makes a total of 28 cases of dermatoses more or less resembling the original. In some the diagnosis was established by microscopic studies, while in others the diagnosis was based merely on the patient's history and the clinical manifestations. In view of the fact that

The name has for many years been applied to a heterogeneous group of inflammatory dermatoses. The vexed question as to what to include and what to omit from the broad concept of is discussed in hundreds of articles, of which many are repetitive and many unproductive. In the curriculum of one of the postgraduate courses in dermatology the lecture on deals with eczema venenatum, seborrheicum, hemostaticum, infectious eczematoid dermatitis, neurodermatitis, dermatophytosis and dermatophytids. This classification, while recognizing different entities, adheres to the morphologic classification of widely differing dermatoses. In recent years much has been added to our knowledge of the subject. Numerous useful and carefully organized facts have come to light and lines have been more sharply drawn. Unna long ago removed seborrheic eczema, better termed seborrheic dermatitis, from the general group and established it as a specific entity bearing no relationship to other members of the

Many contributions dealing with disturbances of fat metabolism have been published in recent years and have furnished much new and valuable information to both the internist and the dermatologist. Among these (to mention only a few) are the lipoid studies in xanthoma of Wile and his collaborators,1the investigations of Schaaf and Werner2in Bloch's clinic on the pathogenesis of xanthoma, several publications by Finney, Montgomery and New3and by Weidman and Schaffer,4dealing in part with xanthoma of the skin and the larynx, involvement of the latter being of particular interest in connection with other varieties of lipoid involvement of the mucosae. Urbach5in a scholarly exposition has added much to the knowledge of several new varieties of lipoid disturbances; these, together with lipoidosis cutis et mucosae, form a group of generalized lipoid diseases with cutaneous manifestations, embracing xanthomatosis, necrobiosis lipoidica diabeticorum and extracellular

This chapter commences with describing the surge of global interest in biomedical science with emphasis on Asia. The reason behind that interest is explained in terms of the industry’s present circumstance and economic potential with an eye on entrepreneurship. The prevalent attitude towards biomedical research and industry – sensationalizing its research potential and the promise of products as well as riches – is placed in perspective in line with the realities and challenges that will be confronted. The roles of academia and regulatory affairs are introduced. The chapter concludes with a survey of biomedical business opportunities and comments on what it takes to be a biomedical runway entrepreneur.

The increase in the employment of blood transfusion in recent years is responsible for the growing interest in problems connected with adequate protection of the recipient against infection with the donor's blood. Today transfusions are administered much more frequently and in a greater number and variety of disease states than heretofore. For example, in response to inquiries in several New York hospitals we have been informed that the number of transfusions has doubled during the past three years. This is due partly to simplification of the technic, easier performance of the operation and increase in hospital facilities, and partly also to the added protection afforded the patient by a more careful selection of donors and the safeguards rendered by the more sensitive serologic tests for syphilis. NEED OF SAFEGUARDS TO PREVENT TRANSFUSION SYPHILIS Fordyce 1 in 1915 reported Dade's case of transfusion syphilis, which is said to be the first

The increase in the employment of blood transfusion in recent years is responsible for the growing interest in problems connected with adequate protection of the recipient against infection with the donor's blood. Today transfusions are administered much more frequently and in a greater number and variety of disease states than heretofore. For example, in response to inquiries in several New York hospitals we have been informed that the number of transfusions has doubled during the past three years. This is due partly to simplification of the technic, easier performance of the operation and increase in hospital facilities, and partly also to the added protection afforded the patient by a more careful selection of donors and the safeguards rendered by the more sensitive serologic tests for syphilis. NEED OF SAFEGUARDS TO PREVENT TRANSFUSION SYPHILIS Fordyce1in 1915 reported Dade's case of transfusion syphilis, which is said to be the first

Detailed reports of observations at necropsy of patients afflicted with dermatoses of unknown cause are only rarely published. We therefore take this opportunity to record the results of the postmortem examination in a case which we reported under the title "Lichen Ruber Moniliformis."1 After the publication of the report the patient had been seen on frequent occasions and at no time showed any change in the appearance of his eruption or in his usual general physical condition. He was admitted to the Scranton State Hospital, Scranton, Pa., on March 5, 1937, in a state of coma. While sitting in a restaurant with his companions, he suddenly experienced severe precordial pain. He was apparently unable to cry out and struggled to rise from his chair. His companions stated that his arms shook as in a convulsion and he fell to the floor, striking his head against a radiator. He was

The glomus tumor has already been described in the American literature of surgery (Adair 1 ) and of pathology (Popoff 2 ). It has received more general attention in The Journal of the American Medical Association. 3 Recently Stout 4 has described it thoroughly for the oncologists. It is therefore superfluous to repeat the details of the subject, however desirable they might be for the fullest understanding of the circumstances attending our case. In brief, the neuromyo-arterial glomus is a normal vascular anastomosis which is distinctive in two respects: (1) it is arteriovenous, i. e., there are not any intervening capillaries, the structure having a special and peculiar architecture, and (2) it includes special arrangements of muscle and nerve tissue. It occurs almost exclusively, as known at present, on the extremities, both upper and lower. It is supposed to play an important part in heat regulation. It assumes dermatologic

An interesting article entitled "New Forms of Papillomatosis'' was published in 1932 by Gougerot and Carteaud,1of France. Since the American literature contains no reference2to dermatoses of this kind, we believe that a report of an example of a rare dermatosis belonging in this group is warranted. Gougerot and Carteaud pointed out that the literature concerning cutaneous papillomatoses reveals an astonishingly meager amount of information, that such eruptions are rare, that they are not generally recognized as forming a self-sustained group and that they are confused with verrucose proliferative dermatoses. They stated further that in their opinion there was a need for segregation and identification—at least from the clinical aspect—of such a group of rare dermatoses. They described and illustrated with photographs three groups, as follows: Group I. Punctate, pigmented, verrucous papillomatosis. Group II. Confluent and reticulated papillomatosis. Group III. Nummular and confluent papillomatosis. The patient whose

The prevailing general belief that so-called lichen ruber moniliformis is a variety of lichen planus does not receive support from our investigations of a dermatosis in many respects similar to the lichen ruber moniliformis originally described by Kaposi. In the present report the name lichen ruber moniliformis is used mainly for the purpose of identification. Eleven biopsy specimens from our patient failed to reveal the usual histologic evidences of lichen planus. An analysis of the cases recorded in the literature justifies the assumption that in nearly all those reported as instances of lichen ruber moniliformis the conditions were actually varieties of lichen planus. However, in a small minority the disorders certainly seem to belong in another category ; of the latter group Kaposi's original case and our own case appear to be outstanding instances, since the conditions in these cases were not related to lichen planus or to any other

This is one of a series of articles written by eminent clinicians for the purpose of extending information concerning the official medicines. The twenty-four articles in this series have been planned and developed through the cooperation of the U. S. Pharmacopeial Committee of Revision and The Journal of the American Medical Association.—Ed. In this article we shall confine ourselves to a discussion of the use of parasiticides in the parasitic disorders occurring in dermatologic practice. A discussion of the use of these remedies in diseases of nonparasitic origin would lead us too far afield, since it would embrace almost the entire field of dermatotherapeutics. In the accompanying list are the most important members of the group of drugs referred to as the parasiticides. They form the basis of present-day antiparasitic therapy. There are other remedies, some of which will be mentioned in the text, but these are purposely omitted in

Interest in the broad subject embraced by the term dyshidrosiform eruptions of the hands and feet has in recent years acquired a tremendous impetus as a result of the discovery that a primary fungous infection of the skin of the feet may give rise to secondary vesicular and other inflammatory lesions on the hands and on other parts of the body.1 The incidence of superficial mycotic lesions of the skin has become so widespread in most parts of the world, and especially in this country, that opportunities for study and investigation are unlimited; advantage has been taken of these opportunities by scores of clinical observers and laboratory investigators, with the result that more light is constantly thrown on the various phases and problems connected with dyshidrosiform dermatoses as a whole. These investigations have led to ramifications embracing the fields of atopy, allergy, immunology, mycology, biologic

To the Editor:—In the issue of theArchivesof November 1935 (vol. 32, p. 787) is an article by Robinson and Grauer, entitled "Use of Autogenous Fungus Extracts in the Treatment of Mycotic Infections." In their concluding remarks these authors stated: "A series of patients with mycotic infections successfully treated with autogenous extracts is reported." Also: "Clinical and bacteriologic cures obtained by treatment with fungus vaccine recommend it as a means of therapy for refractory dermatomycoses." These statements indicating good results are much at variance with those made in other articles, notably those of Traub and Tolmach (Dermatophytosis: Its Treatment with Trichophytin,Arch. Dermat. & Syph.32:413, [Sept.] 1935. Transactions of the Ninth International Congress of Dermatology, Budapest, Hungary, Sept. 13 to 21, 1935, p. 714). Traub and Tolmach stated: "It seems to us that in evaluating a remedy for such a capricious disease as superficial dermatophytosis with

The accompanying illustration and table give our suggestion for a schematic and tentative classification of the various common allergic dermatoses. The division is based on (a) the site of the shock tissue (epidermis or cutis) and (b) the length of time required for the development of the visible reaction, after the union of allergen and sensitized tissue. In each of the first three groups the reaction to skin testing is characteristic: this has served as the criterion Classification of Various Common Allergic Dermatoses Eczematous Reactions Site of shock tissue: epidermis Reaction time: twenty-four or more hours Characteristic lesion: spongiosis and intra-epidermal vesicle Causative substances: frequently simple chemicals or products of fungi Type of test: patch test Tuberculin-Trichophytin-Type Reactions (not infrequently combined with eczematous responses) Shock tissue: upper cutis, cutis Reaction time: from twenty-four to forty-eight or more hours Characteristic lesion:

The practice of a profession affected with a public interest always precedes the establishment of accepted discipline for training in that profession and the development of provisions for the supervision and control of the practice itself. Medicine is no exception to this rule. The time has now arrived, with respect to the general practice of medicine, when preparation for admission is provided by excellently equipped medical schools, and admission to general practice is rigorously controlled by the various states. Almost no provision has been made, however, for the supervision of the more recently developed phase of medical practice, namely, specialism. With a few notable exceptions, the medical schools offer little opportunity for graduate specialization. Moreover, admission to general practice empowers the physician to undertake the treatment of any and all diseases. There are 160,000 licensed physicians in the United States. Any one of these may set himself up as a