Poster: ECR 2015 / C-0535 / Asymmetry of cerebral venous outflow by: L. Savelyeva, Y. Stankevich, O. Bogomyakova, A. Tulupov ; Novosibirsk/RU
The epidemic of cardiovascular disease is nonexistent in cultures which thrive predominantly on whole foods, plantbased nutrition. Is it logical to assume that patients with this disease would be willing to transition to plant-based nutrition and might this transition halt or reverse the disease? The authors have experience beyond 25 years demonstrating the success of plant-based nutrition in arresting and reversing cardiovascular disease. Nevertheless, the medical community is still skeptical of patients’ adherence and efficacy of this method. We, therefore, report three case histories of carotid, coronary, and peripheral vascular disease. Each case demonstrates disease progression and the failure of the standard cardiovascular approaches in contrast to the prompt, powerful and enduring resolution of disease with whole foods, plant-based nutrition. These outcomes constitute an additional mandate that patients with cardiovascular disease be offered a plant-based option which is safe, inexpensive, empowering, and has the potential to end cardiovascular disease epidemic.
EC coupling is subjected to a mechanical feedback, which originates from physical force-sensing ion channels in the pericardium and elsewhere. Reviewed here are the most recent developments that greatly advanced our understanding of these mechanosensitive (MS) channels, including TRPs and K2p’s. Patch clamp has continued to demonstrate the direct channel activation by membrane stretch. Crystallography and cryo-electron microscopy have revealed the structures of several MS channels at atomic resolution. Some have been purified to homogeneity, reconstituted into lipid bilayer, and still retain their ability to respond to stretch force. A force-from-lipid (FFL) theory has been advanced that emphasizes the strong binding between channel proteins and lipids. Through these bonds, the sharp lateral tension (akin to surface tension) of the bilayer can transmit added force to the channel protein. Like temperature sensitivity, sensitivity to mechanical force is far more pervasive than we previously realize, and is especially important to the beating heart.
Evidence-performance-gaps between guidelines and treatment of type 2 diabetes (T2DM) in daily practice have been reported, especially in primary care. We aimed to assess the potential gap comparing current treatment in primary care with guidelines and patients’ characteristics from large clinical trials that guidelines are based on, namely UKPDS, ACCCORD, ADVANCE, STENO-2 and VADT. Methods: We undertook a cross-sectional study and extracted data on 541 patients with T2DM from a clinical information system of a GP network in Switzerland. Results: Our study population was comparable to patients in ACCORD, ADVANCE and VADT at baseline. Patients in UKPDS and STENO-2 differed in age and disease duration. HbA1c-levels (7.3%), LDL-level (2.6 mmol/l), systolic and diastolic (135/78 mmHg) blood pressure were lower in our study than in the reference studies. 39.4% received an ACE-inhibitor, 41.6% statins and 41.4% aspirin. Conclusion: Taking into consideration the results of recent large clinical trials indicating that very strict treatment goals are of no additional benefit, most patients in Swiss primary care would not benefit from a treatment intensification regarding HbA1c, blood pressure and cholesterol targets. Evidence-performance-gaps were observed mainly concerning the choice of first line medication.
