In this study, pure hydroxyapatite (HAp) was successfully produced by using eggshells. The eggshells were collected locally and calcined to get CaO from them. The CaO powder was reacted with diammonium hydrogen phosphate in a mechanochemical method using attritor milling. A portion of the synthesized samples was subjected to a second calcination process at 900 °C to investigate the thermal effects on the material. The structures of the samples were investigated by scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. The as-prepared HAp appeared to be nanocrystalline with low-intensity reflections, which transformed into a highly crystalline hexagonal phase after heat treatment, as revealed by XRD analysis. Quantitative analysis revealed the thermal evolution of the secondary Ca(OH)2 phase, due to the thermal decomposition into CaO without causing HAp decomposition into tricalcium phosphates. FTIR analysis showed characteristic phosphate bands for both samples, but the calcined sample displayed sharper peaks and a clear loss of residual water and carbonates. SEM observations also highlighted the major morphological transformation. The highly aggregated as-prepared nanoparticles formed larger, well-defined grains. Notably, the calcined sample also exhibited a rough, textured surface with a macroporous network with interconnected channels. EDS analysis confirmed a Ca-P-O-rich composition, where the elevated Ca/P ratio (Ca/P = 2.28) suggested the presence of secondary calcium-rich phases. These structural, chemical, and morphological characteristics suggest that eggshell-derived HAp, with or without a second heat treatment, has high potential and may be optimized for different applications in bone tissue engineering. However, biological performance was not evaluated in this study.
Nanoscale liquid film boiling is a key heat transfer mechanism in high-heat-flux thermal management, but the coupled effects of wall vibration and surface wettability remain unclear. In this study, molecular dynamics simulations were performed to investigate water film boiling on platinum surfaces under different wettability conditions, vibration amplitudes, and vibration frequencies. The results show that surface wettability strongly regulates the balance between early nucleation and later heat transfer deterioration. Under wall vibration, the neutral-wettability case (β = 0.02) shows the most favorable overall behavior, with bubble nucleation occurring at 0.35 ns, 46.2% earlier than that for β = 0.013, while the Leidenfrost onset is delayed to 1.65 ns, 153.8% later than that for β = 0.1. For vibration amplitude, increasing the amplitude from 0.5 to 2 Å advances bubble nucleation by 70.8%, whereas further increasing the amplitude to 3-4 Å accelerates Leidenfrost onset by 51.5-75.8%. For vibration frequency, compared with the non-vibrating case, nucleation is advanced by 36.4%, 54.5%, and 81.8% at 100, 150, and 200 GHz, respectively. These results indicate that moderate vibration enhances interfacial energy exchange, whereas excessive vibration promotes premature vapor-layer formation and heat transfer deterioration.
The sustainable bio-activated carbon platelets were synthesized from tamarind (tamarind indicia) fruit seed shells (TFSs) by a pyrolysis approach with an inert gas atmosphere. The carbonization process was carried out at 800 °C under an inert argon atmosphere, yielding both pure TFS-AC and chemically activated TFS-AC (KOH) carbon materials. Microscopic surface morphological analysis confirmed the formation of thin, interconnected porous carbon platelet nanosheets with enhanced surface structural uniformity. Raman spectroscopy revealed characteristic D- and G-bands, signifying the presence of graphitic domains and partial structural disorder. BET surface area analysis indicated a significant improvement from 48.54 m2/g in TFS-AC to 124.72 m2/g in TFS-AC (KOH), suggesting enhanced pore development and surface accessibility due to KOH activation. Electrochemical two-electrode performance was evaluated in symmetric device configurations using 3M KOH aqueous electrolyte. The TFS-AC (KOH) device exhibited a remarkable specific capacitance, which delivered 129.03 F/g at 0.5A/g, compared to the pure TFS-AC device. Electrochemical impedance spectroscopy (EIS) further confirmed low internal resistance and favorable ion transport. These findings confirm that KOH-activated TFS-derived carbon nanosheets have higher electrochemical stability, retaining 98.2% capacitance over 10,000 cycles. These results are promising electrode materials for high-performance supercapacitor applications, owing to their superior electrochemical symmetric device performance of bio-mass carbon Tamarind seed shell platelet nanosheets for future energy storage symmetric device applications.
One of the main issues in oncology is tumor recurrence following resection, which is responsible for a large number of patient deaths and treatment failures in a variety of malignancies. Despite advancements in adjuvant chemotherapy and radiation, residual disease that remains inside or close to the resection cavity and is difficult for systemic therapies to eradicate is the cause of further local recurrence. Hydrogel-nanoparticle (HNP) composites are a new class of therapeutic platforms that emerged from the recent convergence of biomaterial science and nanomedicine. Their specific goals are to fill the surgical gap, provide long-term localized drug release, and energetically remodel the post-surgical tumor microenvironment (TME). This paper includes the biological foundations of localized post-surgical therapy, important physicochemical considerations of the hydrogel matrix and nanoparticle carrier design, and a compilation of mechanistic and preclinical evidence for HNP hybrid platforms. Immunomodulatory strategies, stimuli-responsive release mechanism engineering, and novel techniques, including combination immunotherapy and 3D-printed customized scaffolds, are all given special attention. Examples of translational challenges are also addressed, such as manufacturing repeatability, biocompatibility, and regulatory classification. When considered collectively, the data demonstrate that HNP platforms are a convincing, practically feasible approach to reducing post-surgical recurrence rates and enhancing patient outcomes.
Van der Waals indium selenide is a promising material for next-generation optoelectronics due to its thickness-dependent band structure and high carrier mobility. Here, we investigate the optical properties of size-selected liquid-phase exfoliated γ-InSe nanosheets. The dispersions, composed of flakes with lateral dimensions below 100 nm, exhibit pronounced structural disorder and size-dependent optical behavior. Absorbance spectroscopy reveals systematic changes across size-selected fractions, enabling the extraction of quantitative metrics for estimating nanosheet lateral size and layers number. In addition, stability studies demonstrate significant degradation under ambient conditions, which is accelerated at elevated temperatures. Photoluminescence measurements on nanosheets exfoliated under inert conditions show broad, asymmetric emission with a clear blue-shift for smaller flakes, reflecting quantum confinement and dielectric screening effects. The emission characteristics further indicate a dominant contribution from localized states associated with disorder. These findings provide insight into the structure-property relationships in liquid-phase exfoliated γ-InSe and highlight its potential for solution-processed optoelectronic applications.
Food contaminants, including plasticizers, pesticide residues, heavy metals, and biotoxins, pose persistent risks to food quality and human health. Their diverse sources, complex migration pathways, and potential long-term toxicity make removal difficult. Conventional removal technologies, such as physical treatment, chemical degradation, adsorption, membrane separation, and biological methods, can reduce contaminant levels to varying degrees. However, they often show limited selectivity, matrix interference, harsh operating requirements, or losses of nutritional and functional components. Molecularly imprinted polymers (MIPs) are synthetic recognition materials with binding sites tailored to a target contaminant. Their template-induced cavities provide complementarity in size, shape, and functional-group arrangement, enabling selective adsorption in complex matrices. Recent studies apply MIPs to the enrichment, detection, and removal of plasticizers, pesticide residues, heavy metals, and biotoxins. Unlike recent surveys centered on MIP-assisted analysis and sensing, this review uses contaminant removal as the organizing problem and compares MIP-based strategies with conventional decontamination across four hazard classes. MIPs offer tunable selectivity, chemical stability, and reusability, but practical food applications still face template leakage, slow mass transfer, incomplete safety evaluation, matrix dependence, and scale-up limitations. Future work should prioritize green synthesis, surface imprinting, magnetic recovery, and systematic validation in real food matrices. To prevent analytical extraction from being conflated with remediation, the evidence is classified from proof-of-binding and analytical cleanup to edible-matrix treatment and process validation, and representative studies are compared using capacity, removal or recovery, equilibration time, selectivity, reuse, and matrix validation. Recent evidence also reveals substantial gaps for PFAS, microplastics, and nanoplastics: selective recognition is advancing, but food-safe removal remains largely unvalidated.
Predicting the cytotoxicity of engineered nanoparticles remains a significant challenge due to the vast combinatorial diversity of their physicochemical properties. In this study, we developed a multimodal generative framework to synthesize high-fidelity nanoparticle candidates with predefined toxicity indices. We used a large language model to extract heterogeneous data from scientific articles and utilized SciBERT-based embeddings to encode unstructured textual toxicity summaries. Four generative architectures-CTGAN, TVAE, WGAN-GP, and TabDDPM-were benchmarked using the Synthetic Data Vault quality score. The TabDDPM demonstrated superior performance in capturing complex structure-activity relationships, achieving an SDV quality score of 0.78. The case study validation and feature evolution analysis prove the practical efficacy of the TabDDPM. To validate the physical plausibility of the best generated model, we conducted coarse-grained molecular dynamics simulations in the GROMACS 2026.0 engine using the Martini 3.0.0 force field. Comparative analysis of safe and toxic nanoparticles candidates revealed that the toxic variant induced 2.4 times higher electrostatic stress (88.76 kJ/mol) and significantly prolonged membrane equilibration times. The safe candidates had a lower center-of-mass distance between the nanoparticle and the hydrophobic core of the lipid bilayer compared to the toxic counterpart. These results confirm that the proposed generative approach not only replicates statistical distributions but also captures the underlying biophysical mechanisms of membrane disruption, providing a potentially robust tool for the in silico design of biocompatible nanomaterials.
The unique contributions of 2D Ti3C2 MXenes surface, electrical, and chemical features play a crucial role in determining toxic and flammable gas-sensing behavior. Specifically, its high electrical conductivity (metallic nature), layered nanosheet structure (nanosheets), and surface termination groups (-O, -F, and -OH) collectively contribute to excellent hydrogen (H2) and ammonia (NH3) gas-sensing behavior. This review systematically explores the impact of pristine and modified Ti3C2 MXene, including its interfaces with various metals and metal oxides for enhancing H2 and NH3 detection. Furthermore, the significance of room temperature operation and flexible gas sensing mechanisms is explored. Notably, integration of Ti3C2 MXene and sulfur nanosheets demonstrates rapid response and recovery times with detection limits at ppt level. Ti3C2 MXene-based interfaces also exhibit excellent long-term stability under various relative humidity conditions. The selective surface termination groups (-OH and -O) facilitate the formation of hydrogen bonds with NH3 molecules for enhancing gas adsorption and sensing selectivity. In addition, the expansion of the interlayer spacing plays a vital role in improving the gas-sensing performance. Partial oxidation of Ti3C2 MXene into TiO2 increases the interlayer distance, promoting faster diffusion of gas molecules and quicker sensor response. Overall, the intrinsic properties of Ti3C2 MXene and its composites significantly achieve high-performance room-temperature H2 and NH3 gas-sensing performance.
In the field of long-distance partial discharge (PD) detection for submarine cables, there is an urgent need for a remote demodulation distributed detection technology deployable at multiple critical locations to overcome the limitations of single-point measurement. Factory joints of high-voltage submarine cables are high-risk components for PD, and long-distance fiber optic acoustic sensing technology holds the greatest potential for online monitoring. However, due to the viscoelasticity of the joint’s polymer insulation structure, sound propagation distance is severely limited, and non-multi-point measurement cannot achieve effective coverage of the measurement area. This paper proposes a quasi-distributed remote demodulation sensing system, in which both the fiber optic interferometer and the distributed feedback fiber laser (DFB-FL) serve as sensors, enabling highly sensitive quasi-distributed PD detection. The DFB-FL itself is highly sensitive to strain, and the multiple fiber coils formed by the interferometer arms are also highly sensitive to strain. Both can be modulated by the micro-strain induced by the acoustic field generated from PD in the polymer solid, producing phase shifts of the optical waves, which are then intrinsically demodulated by the interferometer system to extract the vibration signals caused by the discharge. Theoretical analysis shows that the sensitivity increases with the length of the unbalanced arm, with the upper limit constrained by laser coherence and optical attenuation; for the PD frequency band, the optimal unbalanced length is below 200 m—this design rule is applicable to on-chip interferometric sensors. The interferometer coils employ bend-insensitive fibers to suppress optical loss and improve fringe visibility. Meanwhile, three fiber coil configuration schemes are constructed to enhance the detection sensitivity to acoustic signals. Simulation results generate frequency response contour maps based on Young’s modulus, indicating that the solid-wound coil achieves the highest amplitude and the broadest bandwidth, with an optimal response frequency of approximately 50 kHz. Experimental results demonstrate that among the three structure types, the solid-wound coil also achieves the largest response ratio. Finally, in tests performed on a 220 kV submarine cable intermediate joint (with the system installed inside the metallic sheath), the minimum detectable discharge level in the DFB-FL region reached 6.75 pC, while that for the fiber coil reached 12.66 pC; when installed outside the metallic sheath, the minimum detectable discharge levels were 53.2 pC for the grating region and 89.6 pC for the fiber coil.
The precise control of optical and dielectric properties of semiconductor quantum-dot-based thin films remains a critical challenge for advanced optoelectronic applications. In this respect, (3-mercaptopropyl)trimethoxysilane (MPS)-capped CdS quantum dot thin films were prepared with MPS:Cd molar ratios of 0.25, 0.50, 1.00, and 2.00 to investigate the role of MPS content in tuning their optical and dielectric properties. The colloidal quantum dot solutions were deposited onto glass substrates by spin coating and subsequently annealed in air at 350 °C. Optical analyses showed that increasing MPS content enhanced film transmittance, whereas the refractive index, extinction coefficient, dielectric loss tangent, and optical conductivity decreased. At 550 nm, the refractive index decreased from 2.12 to 1.61, while the optical conductivity decreased from 6861 to 644 S m-1 as the MPS ratio increased from 0.25 to 2.00. The Urbach energy exhibited a non-monotonic variation, reaching a maximum value of 415 meV at MPS:Cd = 0.50 and a minimum value of 193 meV at MPS:Cd = 2.00. Wemple-DiDomenico analysis revealed that the single-oscillator energy increased systematically with increasing MPS ratio, and the E0/E1S-1S ratios remained within a narrow range of 1.32-1.46 throughout the MPS:Cd series. The analysis further revealed that the dispersion energy, static refractive index, infinite-wavelength dielectric constant, and linear susceptibility decreased with increasing MPS molar ratio. The estimated third-order nonlinear optical susceptibility and nonlinear refractive index also decreased with MPS content.
Microplastics and nanoplastics (MNPs) have been recognized as ubiquitous emerging global pollutants, which are extensively detectable in diverse environmental media and food matrices. Increasing evidence indicates that the intestine is a primary target of orally ingested MNPs and a critical initiating hub for systemic toxicity. Once ingested orally, MNPs can interact with the intestinal mucus layer and epithelial barrier, induce gut microbiota dysbiosis, remodel bile acid and short-chain fatty acid metabolism, and activate oxidative stress, inflammation, apoptosis, and immune imbalance. These gut-derived disturbances may subsequently propagate adverse signals to distal organs through the gut-liver, gut-brain, gut-kidney, gut-lung, gut-reproductive, and gut-mammary axes. Intestinal barrier dysfunction, endotoxin translocation, abnormal microbial metabolites, and microbiota-derived immune signals constitute common mediating pathways linking local intestinal injury to multi-organ toxicity. In addition, smaller particle size, surface oxidation, environmental aging, bio-corona/plastisphere formation, and co-exposure with other contaminants can further modulate the intensity and specificity of gut-organ axis disruption. Prior reviews are limited to separate analyses of single-organ toxicity or isolated gut-organ pathways. To fill this gap, this work synthesizes contemporary mechanistic and experimental evidence to establish a gut-initiated systemic toxicology framework for MNPs. We differentiate direct particle translocation from gut-derived indirect signaling, evaluate the varying robustness of supporting evidence for each gut-organ axis, and underscore nanoscale biointerface properties as key modulators of MNPs systemic toxic potency.
The development of reusable nanomaterials for the extraction of trace-metals from complex matrices remains challenging because strong metal-chelating functionalities often hinder desorption and regeneration, whereas weaker binding sites compromise selectivity and enrichment efficiency. This limitation has been addressed by designing a ligand-engineered fibrous mesoporous silica nanomaterial (Van-KCC-1) via the integration of the unique structural features of KCC-1 with an o-vanillin-derived Schiff-base chelator. The material was synthesized throughout the chemical grafting of 3-aminopropyltriethoxysilane (APTES) onto fibrous mesoporous silica KCC-1, followed by condensation with 3-methoxy-2-hydroxybenzaldehyde (o-vanillin). The successfulness of functionalization and Schiff-base formation were confirmed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). The radially oriented fibrous channels of KCC-1 provide a highly accessible surface that remains available for interaction with the targeted ions even after chemical modification. This architecture facilitates rapid mass transfer and efficient utilization of binding sites, while the incorporated Schiff-base ligand introduces imine, phenolic, and methoxy donor groups capable of selectively and reversibly coordinating Ni(II) and Cd(II). The resulting balance between adsorption strength and desorption efficiency enables both effective metal capture and sorbent reusability. More importantly, the study demonstrates how KCC-1 can serve as a versatile nanosilica scaffold for the incorporation of tailored chelating ligands without sacrificing structural accessibility. The functionalized nanomaterial was evaluated as a dispersive solid-phase extraction (DSPE) sorbent coupled with inductively coupled plasma optical emission spectrometry (ICP-OES). Under optimized conditions, linear ranges of 0.035-50 μg L-1 for Ni(II) and 0.058-50 μg L-1 for Cd(II) were obtained, with limits of detection of 0.011 and 0.019 μg L-1, respectively. The method exhibited excellent precision (relative standard deviation ≤ 3.6%) and recoveries of 92.00-98.83% in certified reference materaisl (NIST CRM 1643d), mineral water, tap water and synthetic wastewater. In addition, the nanochelator has retained more than 87% of its initial sorption efficiency after six adsorption-desorption cycles and showed minimal interference from common coexisting ions. These findings establish Van-KCC-1 as an efficient, selective, and reusable DSPE sorbent in the determination of trace-metals while highlighting the broader potential of fibrous mesoporous silica KCC-1 as a platform for the rational design of next-generation chelated nanomaterials.
ε-phase indium selenide (ε-InSe), a non-centrosymmetric van der Waals layered semiconductor, exhibits broken inversion symmetry in all layer numbers, giving rise to exceptional second-order nonlinear optical responses and holding great promise for nonlinear optoelectronic applications. The dynamic control of the nonlinear efficiency of ε-InSe is crucial for its engineering applications. However, the quantitative manipulation of second-harmonic generation (SHG) intensity and crystal symmetry in few-layer ε-InSe via strain engineering is still lacking. In this work, we systematically investigate the modulation of SHG intensity and angle-resolved SHG patterns in few-layer ε-InSe under uniaxial tensile strain. Using a home-built straining apparatus, we apply controlled tensile strain and measure the strain-dependent SHG responses. The experimental results demonstrate that the SHG intensity of few-layer ε-InSe shows a non-monotonic response to increasing tensile strain, first increasing and then decreasing. Concurrently, the sixfold symmetry of the SHG pattern is broken, confirming the significant strain-induced modulation of the lattice symmetry. This study provides a viable route for the design of flexible and tunable nonlinear optoelectronic devices based on ε-InSe.
Three-dimensional (3D) graphene foams are attractive as lightweight conductive scaffolds with large surface area and broadband light absorption but achieving reproducible porosity and preserving the architecture after metal-template removal remain challenging. Here we report a stepwise route to freestanding 3D multilayer graphene foams based on (i) hydrogen-bubble-assisted electrodeposition of porous Ni on Cu foils, (ii) time-controlled pre-annealing at 1000 °C to drive Cu diffusion and form porous Ni-Cu alloy templates, (iii) in situ graphene CVD at 1000 °C under fixed growth conditions, and (iv) wet etching to remove the metal scaffold without a polymer support. The influence of pre-annealing (0, 1, 3, and 7 h) on template evolution, graphene growth, and foam stability was systematically investigated via SEM, EDS, XRD and Raman studies. Before etching, Raman spectroscopy indicates low-defect graphenic coatings with locally heterogeneous few-layer-like to multilayer-like signatures. Only samples pre-annealed for at least 3 h preserved the porous 3D architecture after metal removal, indicating the formation of self-supporting graphenic networks with improved post-etch morphological stability. Raman and XRD analyses further revealed a progressive reduction in structural degradation, residual strain, and stacking disorder with increasing pre-annealing time. Among the investigated samples, the foams obtained after 3 and 7 h of template pre-annealing combined preserved 3D morphology with low sheet resistance (10-20 Ω/□), negligible optical transmittance (<5%), and strong broadband visible-light absorption (75-90%).
Semiconductor-based photocatalytic water splitting is a promising pathway for sustainable hydrogen production; however, the reported performance depends not only on the intrinsic properties of the photocatalyst but also on reactor configuration and operating conditions. This systematic technical review examines the interplay between nanostructured semiconductor photocatalysts and the principal engineering variables governing photocatalytic hydrogen evolution. Particular attention is given to particle size, morphology, surface area, defect density, heterojunction design, cocatalyst incorporation, aggregation, and catalyst immobilization, as well as their interaction with reactor geometry, optical path length, photon distribution, catalyst loading, working volume, pH, sacrificial agents, mixing, thermal control, gas purging, and product quantification. The reviewed evidence indicates that these material and reactor parameters jointly determine light absorption, charge-carrier separation and transfer, suspension turbidity, mass transport, catalyst recovery, stability, and the measured hydrogen evolution rate. Batch slurry reactors remain the most widely used laboratory configuration, whereas annular, flat-panel, microreactor, fixed-bed, continuous-flow, and photofluidized systems offer specific advantages for photon utilization, catalyst reuse, product removal, and scale-up. The review also emphasizes the need to distinguish overall water splitting from sacrificial-agent-assisted hydrogen evolution. Standardized reporting of photocatalyst properties, irradiance, spectral distribution, illuminated area, reactor dimensions, reaction atmosphere, and gas-analysis procedures is essential to improve reproducibility and enable reliable comparisons among nanostructured photocatalytic systems.
Aim of the study: This study aims to isolate extracellular vesicles derived from Elaeocarpus braceanus fruits (EBDEVs) and evaluate their alleviating efficacy as nature nanoparticles against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Methods: EBDEVs were isolated by differential and density gradient ultracentrifugation, then characterized for morphology, size, stability, and composition. Their anti-inflammatory activity was assessed in LPS-stimulated RAW264.7 macrophages. In vivo, acute UC was induced in C57BL/6 mice by 2.5% DSS. Disease severity, intestinal barrier integrity, TLR4/MyD88/NF-κB pathway activation, and gut microbiota composition were evaluated. Results: EBDEVs exhibited a typical spherical structure and were rich in bioactive components such as lipids, flavonoids, and terpenoids. Macrophages readily internalized them and significantly inhibited LPS-induced NO production. In UC mice, EBDEVs ameliorated weight loss, colon shortening, and tissue damage, while reducing serum inflammatory cytokines. EBDEVs restored intestinal barrier function by regulating tight junction proteins. Mechanistically, EBDEVs suppressed the activation of TLR4/MyD88/NF-κB and downstream NLRP3 inflammasome inflammatory signaling cascades, and remodeled the dysregulated gut microbiota structure. Conclusions: EBDEVs alleviate DSS-induced UC in mice by repairing the intestinal barrier, inhibiting inflammatory pathways, and modulating gut microbiota.
Background/Objectives: Poor aqueous solubility and low bioavailability limit the therapeutic use of many hydrophobic anticancer agents. This study developed liposomal and polymeric micellar formulations of a fluorinated curcumin derivative (FCur) and naringenin (NG), prepared as single-compound and mixed systems, and compared their physicochemical and biological properties. Methods: Soluplus®-based polymeric micelles and POPC:DOTAP liposomes were prepared by the thin-film hydration method and characterised using dynamic light scattering (DLS), zeta potential measurements, HPLC, NMR relaxation studies, and in vitro cytotoxicity assays. Results: Polymeric micelles formed homogeneous dispersions with particle sizes below 95 nm and a slightly negative zeta potential (~-3 mV), whereas liposomes were larger (>130 nm) and strongly positively charged (>+40 mV). Both systems achieved high encapsulation efficiencies (>72% for FCur and >95% for NG). NMR relaxation studies revealed more restricted molecular dynamics within liposomal bilayers and greater motional freedom in micelles. In biological studies, FCur and mixed liposomes exhibited the highest overall cytotoxicity against bladder (5637), prostate (LNCaP) cancer as well as normal fibroblast (MRC-5) cell lines, compared with the free compounds and polymeric micelles. Notably, polymeric micelles with FCur (single and mixed) exhibited a more favourable differential cytotoxicity response between bladder cancer and normal cells. Conclusions: These findings demonstrate that the nanocarrier system plays a critical role in determining both molecular dynamics and biological performance of encapsulated agents.
Metal-organic frameworks (MOFs) based on triazole have attracted considerable interest as promising porous materials for CO2 capture due to their high surface area, ultramicroporosity, and excellent thermal and chemical stability. Nitrogen-rich triazole ligands contain abundant Lewis basic sites that promote CO2 adsorption via dipole-quadrupole interactions, hydrogen bonding and cooperative interactions with open metal sites. The present review discusses recent developments in the synthesis of triazole-based MOFs, with special emphasis on the relation between structural features and CO2 adsorption performance. The paper reviews different synthetic routes such as solvothermal, hydrothermal, mechanochemical and post-synthetic modification methods and their impact on crystallinity, porosity and scalability. The roles of metal centres, pore confinement and linker functionalization in tuning CO2 uptake, selectivity and adsorption energetics are highlighted. Moreover, the mixed-linker strategies and defect engineering are explored to illustrate the use of the synergistic effect of nitrogen-rich sites and metal nodes for the improvement of the adsorption performance. Still, a number of challenges remain such as achieving an optimal balance between adsorption strength and regenerability, increasing stability in humid and realistic flue-gas conditions, and the development of scalable and sustainable synthesis routes. In summary, triazole-based MOFs provide a versatile platform for the design of high-performance CO2 adsorbents by combining structural robustness with chemically active, nitrogen-rich adsorption environments.
Nanosomes are small vesicles that are used in precision nanomedicine to deliver therapeutic drugs to specific cells or tissues [...]
