Terminalia Chebula has been extensively used in field of traditional medicine and AYUSH. Recent Studies using fluorescence analysis given a sense of understanding of Terminalia Chebula fruit pulp. Present study is to carry out preliminary phytochemical screening of EEFTC fruit pulp and the Medicinal values . Terminalia Chebula dried fruit The ethanolic extracts were concentrated in Roto flash evaporator and dried and stored in freezer for further biochemical analysis by using screening methods like preparation of smoothie, Phytochemical analysis, evaluation of determination of crude fibre content and antimicrobial activity of plant extracts, Qualitative Phytochemical analysis, we found that the, aqueous, ethanolic extract of T. Chebula (EETC) is rich with all the compound like Phytosterols, Triterpenoids, Carbohydrate, Glycosides, Phenolic compound . The antimicrobial activity index of extracts of Terminalia Chebula dried fruit pulp at different concentrations was also investigated, the antimicrobial activity, indicated by an inhibition zone surrounding the well containing the extract, was recorded if the zone was greater than 8 mm. Terminalia Ch ebula contains biomolecules which already shown the have anti‐viral, anti‐inflammatory, anti‐oxidant properties, against many pathogen microorganism . in present situation of pandemic outbreak, an expedited screening of therapeutically bioactive constituents is required to establish the anti‐SARS‐CoV‐2 property of these herbs.
Sleep is critical to maintaining the immune system and contributes to physical and mental health. Covid-19 crisis has affected the habits of billions of people around the world. Compliance with quarantine restrictions and self-isolation led to an increase in the occurrence of post-traumatic stress, confusion and anger among the population, while social isolation and changes in the daily routine lead to an increased level of anxiety, panic attacks, irrational fears directly negatively affect the quality of sleep. The aim of this work was to analyze the drug and non-drug approaches that are used to improve the quality of sleep in humans. Analyze the pharmaco-safety and potential risks when taking medications intended for pharmacological correction of sleep. Materials and methods. Analysis of scientific publications on drug and non-drug approaches used to improve the quality of sleep in people over the past 10 years on the PubMed platform;analysis of pharmacological safety and potential risks of hypnotics. Results and discussion. Therefore, unfortunately, at the present time there is no ideal hypnotic that would induce sleep without changing its normal structure and side effects. All hypnotics should not be prescribed to patients snoring during sleep, since profundosomnia (deepening sleep) can increase the manifestations of sleep apnea syndrome, myocardial and brain hypoxia. The duration of the appointment of sleeping pills – no more than 3 weeks. Music has been successfully used as a complementary therapy in various fields of medicine. Music can also improve the quality of sleep and reduce pain for the patient, given the subsequent reduction in the effects of sedatives, which will lead to faster weaning from medical ventilation and faster recovery. Therefore, music is a non-drug highly effective method for improving the quality of sleep on a subjective and objective level.
The supplementary intake of vitamin D is one of the most debated topics in the medical field, a source of controversy and convictions that are also strongly antithetical. Both the judgment of clinicians and public opinion consider this vitamin necessary for the maintenance of bone health, but also for the prevention and treatment of a number of diseases, including diabetes mellitus, autoimmune diseases, neoplasms, multiple sclerosis, heart disease, stroke, depression and more association between low levels of serum 25-hydroxyvitamin D. In fact, Vitamin D is responsible for regulation of calcium and phosphate metabolism and maintaining a healthy mineralized skeleton. It is also known as an immunomodulatory hormone. Experimental studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, exerts immunologic activities on multiple components of the innate and adaptive immune system as well as endothelial membrane stability. Association between low levels of serum 25-hydroxyvitamin D. Vitamin D plays a fundamental role in nutrition, especially for the new evidence related to the SARS pandemic Covid-19 and for this reason it is important to maintain optimal levels of the vitamin, controlled through food.
Zinc (Zn) is one of the most biologically significant essential metals, performing signal, adaptive, metabolic, structural, protective, restorative and other physiological functions in the human and animal. Zn homeostasis and functional activity are maintained with the participation of a wide range of epigenetic factors (natural and anthropogenic geobiospheric, alimentary, industrial, social and economic), which are formed in specific regional conditions of the population's life. Despite the long-term study of this problem and a large number of publications, many of its aspects remain insufficiently studied, especially in critical epidemiological situations. Therefore, the purpose of this work was to compare the epidemiological indicators of zinc content in biosubstrates of the inhabitants of Ukraine in the period 2008-2019. (before the COVID-19 pandemic) and in the period 2020-2021 (during the pandemic) for use in therapeutic and prophylactic purposes in the future. The zinc content in blood, hair and urine of 1819 people aged 17-67 years (average age 37 years, men 673, women 1146) was determined using the EMAS-200 CCD atomic emission spectrometer in the period from 2008 to 2021. The results were statistically processed by nonparametric methods. The obtained results showed a generally satisfactory supply of Zn for the population of Ukraine at the regional level with a tendency to limit the size of the cohort of the surveyed with significant deviations. At the same time, attention is drawn to the indicators that indicate a decrease in the general physiological level of the body supply of the examined persons with Zn. They can be deformed due to the uncontrolled intake of zinc preparations by a part of the population during the COVID-19 pandemic. Therefore, further research is needed to study the mechanisms of the observed changes and to develop measures to optimize regional norms of Zn. All human studies were conducted in compliance with the rules of the Helsinki Declaration of the World Medical Association Ethical principles of medical research with human participation as an object of study. Informed consent was obtained from all participants.
The purpose of this work is to describe the organization and the experience gained by the COVID Special Unit of Potenza (Basilicata Region, Italy) in the months of activity in the Covid-19 emergency. It also describes how the use of IT tools has considerably simplified the territorial management of suspected and confirmed Covid19 cases. “Home hospitalization” has become the new model of assistance for the Potenza Unit, with a significant and modern use of telemedicine, self-monitoring and home medical-nursing assistance. Creating new perspectives within a reform of the National Health System for the future territorial management of non-critical Covid-9 patients is, therefore, the key message of our work.
The new Corona-virus, recently called the severe acute respiratory syndrome Coronavirus (SARS-CoV-2) appears for the first time in China and more precisely in Wuhan (December 2019). This infection can be deadly. Seniors, and individuals with other restorative conditions may be more helpless and ended up truly sick. Typically why inquire about into drugs to treat this contamination remains basic in a few investigate laboratories. Natural home grown cures have long been the most, in case not the as it were, cure within the verbal convention for treating sicknesses. Advanced pharmaceutical has known its victory much appreciated to conventional medication, the adequacy of which determines from therapeutic plants. The objective of this think about is to decide in case the components of common root have an anti-viral impact and which can anticipate people from disease by this coronavirus utilizing the foremost dependable strategy is atomic docking, which utilized to discover the interaction between considered atoms and the protein, in our case we based on the inhibitor of Coronavirus (nCoV-2019) primary protease. Chinese Pharmaceutical herbs might be a profitable pool for distinguishing active compounds for treating disease of 2019-nCoV. In this think about, we summarize several dynamic compounds, counting baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that may have potential anti-2019-nCoV effects. We conduct atomic docking to anticipate their capacity for authoritative ACE2, which may anticipate the 2019-nCoV disease. We propose that these chosen compounds worth assist examination for avoiding 2019-nCoV. © 2020, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.
A pandemic occurring microscopic virus which is named 'novel coronavirus' causes respiratory illness and gastrointestinal infections spread by animals and winged creatures By stopping the transmission of respiratory droplets (sniffles, cough), stopping bodily contact with the infected, taking and maintaining extortion about a few severe versatile rules have the ability to put an end in the expansion of this virus Instead of consumption of foods carrying saturated fat or bad cholesterol, individuals should have a diet rich in minerals, beta-carotene, vitamins (C, D, and E) and zinc to improve the innate and adaptive immune system to fight against this virus In purpose to decline the risk of this virus, natural growing color varieties vegetable consumption and reject the refrigerated fat consisting of food along meet with expire periods As excessive intake of vitamin C cause excretory system failure, good and certain of it from cultivated (lemons, tomato, etc ) or artificial sources consumption can improve the immune system against this pandemic and different respiratory problem Lacking Inhibiting or the presence of vitamin D is certainly a major characteristic in COVID-19 individuals, in taking vitamin D (oily fish, beef liver, etc ) could help resist from its own deficiency and another related malady Avoiding foods from outside (such as fast foods, msg , beverages) and increasing the consumption of homemade natural food on daily basis will fill the portion against the risk of this global pandemic In case of maintaining health service issues, provision of certain rules, inhibition of nutrient-rich constituents or particles, and maintaining social distance (6-feet separated) will stop the widespread of this pandemic Declining the provoke of the global food crisis one should preside in maintaining the nutrition and nourishment across the globe, with extreme results for health and substance
Hypertension is the most common comorbidity found in COVID-19 patients, which might increase the risk of mortality. Inhibitors of the RAAS are among the first-choice agents in hypertension, including ACE-I and ARB. The use of RAAS inhibitors is thought to increase the expression of ACE-2 receptors, facilitating the entry of SARS-CoV-2, which might result in increased mortality, though previous studies got conflicting results. This evidence-based case report was made to answer whether the use of RAAS inhibitors increases the mortality in COVID-19 patients. We explored studies relevant to our clinical question, including only systematic reviews, meta-analyses, and cohort studies that compared mortality rate in hypertensive COVID-19 patients receiving RAAS inhibitors to those who were not. Articles were then selected by title and abstract screening and elimination of articles that did not fit our clinical question and eligibility criteria. The result of selected papers was then critically appraised according to the validity, importance, and applicability of the studies using the critical appraisal form from CEBM. From 191 articles initially found, three studies fit our eligibility criteria (1 systematic review, evidence level 2A, and two cohort studies, evidence level 2B). The systematic review shows an OR of 0.73 ((95% CI 0,56-0,95;p = 0.001) with substantial heterogeneity (I2=74%). The first cohort study shows an HR of 0,97 (95% CI 0,89-1,06) in patients receiving ACE-I and HR of 0,98 (95% CI 0,89-1,06) in patients receiving ARB compared to those who received CCB. The second cohort study shows an OR of OR: 0.623 (95% CI 0.423-0.917;p = 0,016). Findings gathered from various studies showed inconclusive results regarding the use of RAAS inhibitors in hypertensive COVID-19 patients. From our critical appraisal, we found that RAAS inhibitors’ usage tends not to increase the mortality of COVID-19 patients. Thus, we suggest that COVID-19 patients on RAAS inhibitors should continue with their treatment regimen. A large-scale cohort study is still needed to get a conclusion with more robust evidence. © 2020, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.
SARS-CoV-2 infection represents an emerging public health problem with worldwide involvement since its first isolation in Wuhan, Hubei province, China in December 2019 Central nervous system and heart appear to be more affected organs beyond lungs;moreover an increasing cases of peripheral nervous system involvement associated with COVID-19 as inflammatory polyradicoloneurophaty are reported We report a case of Guillain-Barre syndrome in a 75-year-old female associated with SARS-CoV2 infection
