Fractals are geometric shapes characterized by self-similarity, where patterns repeat at different scales and are common in nature. The box-counting method is used to measure their dimension, but it has a key limitation: it only offers a global and homogeneous characterization, ignoring local variations in density or complexity within the structure. Multifractal analysis solves this problem. Instead of a single dimension, it provides a spectrum of dimensions that maps how regularity varies in different parts of the object, offering a more accurate description of complex and heterogeneous systems. These concepts are relevant to endocrinology and medicine through the study of biological systems with fractal geometry, such as the branching of blood vessels or neurons. Multifractal tools help researchers measure the complexity of these structures and dynamic processes (such as hormonal rhythms), potentially improving the diagnosis and understanding of various pathologies.
This project investigates the emotional, sensory, and physical burden of physical traumas, focusing on the influence of the language in which the trauma is discussed. Using neurolinguistics applied to trauma, we explore how the trauma experience can be modulated when discussed in a language different from the mother tongue or the one in which the trauma occurred. The study aims to understand the effects of this linguistic approach on individuals' emotional and physical responses, with the potential to develop new therapeutic techniques and more effective treatments for trauma
Familial hypercholesterolemia (FH) is a hereditary condition associated with elevated cardiovascular risk, primarily due to increased LDL levels from a young age. In some cases, total cholesterol and triglycerides are also elevated. This case highlights the variable onset of FH within a family, elevated liver enzymes during statin therapy, and the need for a more aggressive treatment approach. Treatment included dose adjustments of statins and the addition of ezetimibe, with close monitoring for adverse events. Personalized management of FH is essential, balancing the need to control hyperlipidemia and reduce cardiovascular risk against potential liver enzyme elevation from statin therapy.
Acromegaly is characterized by progressive somatic deformity and systemic symptoms associated with excessive growth hormone (GH) secretion. The mean age at diagnosis of acromegaly ranges from 40 to 47 years, with a prevalence of 28–137 per million and an incidence of 2–11 new patients per year. Men and women are equally affected. Due to its slow progression and insidious nature, diagnosis is often delayed.
To determine the effects of aging, early onset obesity, and genetic predisposition on the progression of glycemic parameters, groups of congenic male lean, obese, and obese-diabetic rats (n= 5-6 rats/group) that share the same genetic trait for obesity (the -cp trait) were reared under normal laboratory conditions and feed Purina Rodent chow ad libitum throughout. Rats were subjected to measures of fasting glucose, insulin, and amylin and glycated hemoglobin and on the glycemic response to an oral glucose tolerance at 4 and 12 months of age. Obese animals weighed more than their lean littermates. Fasting plasma glucose, insulin, and amylin concentrations of obese > lean, in increased further in T2DM-prone animals, with the greatest increases in the oldest animals.
