A case is recorded of renal damage, fever and drug rash following twice weekly viomycin treatment. At post-mortem the renal tubules showed necrosis.
The literature of toxic reactions to P.A.S. is briefly reviewed.
A case of bronchogenic carcinoma is recorded showing infiltration of the left pulmonary vein and left auricle of the heart.
Six cases are described in which a paravertebral abscess, dependent upon spinal caries, ruptured into the pleura or lung. Five of these cases were due to tuberculosis and one to actinomycosis.
An outbreak of influenza is described. This occurred among His Majesty's forces serving on a station in the tropics.
Six cases are described to illustrate the clinical and radiological features of diffuse h˦matogenous involvement of the lungs by secondary malignant growths. Confusion with acute phthisis is not uncommon; but the older age and infrequency of h˦moptysis, the relatively slight pyrexia, the radiological appearances in the lungs and sometimes evidence of a primary growth are distinctive features.
An example of malignant adenomatosis (alveolar cell tumour) of the lung is described occurring in a human subject. The literature is discussed and similarities to adenomatosis of sheep and some other animals are noted. These tumours appear to be true alveolar growths, and they show individually a series of stages from purely benign to highly malignant characteristics.
1.Pulmonary cavities close primarily as a result of the inherent concentric retractility of the lung, the negative intrapleural pressure (chest wall pull) being eliminated by the occurrence of compensatory emphysema in the lung adjacent to the diseased area.2.Lung abscess cavities close as a result of the above only in the presence of free drainage.3.Lung abscesses and tuberculous cavities persist as a result of inefficient drainage; the former by the retention of sloughs and infected material, the latter by the trapping of air in the cavity resulting from a partial bronchostenosis chiefly operative during expiration.4.The majority of tuberculous cavities are tension cavities from their inception and remain so until the later stage of the disease.5.During the later stage of the disease tuberculous cavities persist because of the pull of the chest wall, for at this stage free bronchial drainage is usually present.6.Bronchial occlusion is essential for inducing closure of tuberculous cavities.7.All methods of treatment, excluding chemotherapy, from bed rest to thoracoplasty, are based on the same basic principles—viz., limitation of the inspiratory tug on and relaxation of the cavity and its draining bronchi with the ultimate production of an organic bronchostenosis.
MASS tuberculin surveys in South Africa are fraught with many difficulties, more particularly amongst the Bantu in rural areas. It has been the experience of the senior author (B. A. D.) in field investigations amongst the Bantu in Natal that the native regards with suspicion any kind of injection that he is given, particularly if he feels in good health. We have also found in investigations carried out on non-European children that many of the parents are averse to their children having injections, which are often traumatising. For these reasons it was decided to carry out the following study to evaluate the efficacy of the Patch Test as compared with that of the Intradermal Tuberculin Test and to note their comparison on a dark (nonEuropean) skin. A typical Indian school was chosen and about 200 boys, ranging in ages from nine to sixteen years, were examined.
A case of cystic emphysema with interstitial sclerosis has been described. The cystic dilatation of alveoli is probably due to congenital weakness of the elastic tissue.
