The Implementation of a Management Information System in the Pharmacy Department of Hospital X often experiences disruptions in internet connectivity. This study aims to determine the relationship between Human, Organization, and Technology factors and the Benefits of using the management information system in Hospital X. This research adopts a quantitative approach. Primary data were collected through questionnaires and direct interviews with respondents in the Pharmacy Department of Hospital X. The results indicate that Human, Organization, and Technology factors significantly influence the Benefits of using the management information system in Hospital X.
Liver cancer is among the leading causes of cancer-related deaths worldwide, with hepatocellular carcinoma (HCC) being the most prevalent type. Risk factors such as chronic hepatitis B and C infections, alcohol-induced cirrhosis, and prolonged exposure to hepatotoxins contribute significantly to its incidence. Current chemotherapeutic agents often face limitations due to toxicity, drug resistance, and poor patient tolerance, prompting interest in natural compounds with selective anticancer activity. Curcumin, the principal curcuminoid from Curcuma longa (Turmeric), exhibits a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. It has been shown to suppress tumor proliferation, angiogenesis, and metastasis. As Curcumin concentration increases optical density decreases this indicates Curcumin is killing or inhibiting the growth of cancer cells effectively. In the present study, curcumin was extracted from turmeric rhizomes purchased locally, employing the maceration method with ethanol as a solvent. Fresh rhizomes were oven-dried at 105°C for three hours, ground into fine powder, and extracted at a solid–liquid ratio of 1:20 (w/v) for 72 hours at room temperature. The crude extract was concentrated using rotary evaporation, followed by precipitation with distilled water to obtain purified curcumin. Identification of curcumin was confirmed using qualitative lead acetate and boric acid tests. The anticancer potential of curcumin was evaluated using the HepG2 liver cancer cell line. Cytotoxicity was assessed by measuring cell viability, while morphological changes were analyzed through microscopy to identify apoptotic features. The findings, supported by literature, suggest that curcumin induces apoptosis and inhibits proliferation in HepG2 cells, highlighting its potential as a natural therapeutic candidate for liver cancer management.
Background: Paclitaxel, an anticancer drug, can induce neuropathy and is used in animal models to evaluate new therapeutic approaches. It increases oxidative stress, a key factor in peripheral neuropathy. Medicinal and herbal drugs with antioxidant potential are proven as neuroprotective. W. somnifera have proven antioxidant, anti-inflammatory activity. This study aims to assess its efficacy in paclitaxel-induced neuropathy. Aim and Objectives: To carry out phytochemical investigation andto evaluate effect of W. somnifera on behavioral changes like heat hyperalgesia, cold allodynia, mechanical allodynia, locomotor activity, electrophysiological, biochemical, histopathological changes in Paclitaxel Induced Neuropathy in Wistar Rats. Material and Methods: Wistar rats (n=6 per group) were divided into nine groups. Neuropathy was induced with Paclitaxel (2mg/kg, i.p), administered on days 0, 2, 4 and 6. Treatment with W. somnifera (100, 200, 400mg/kg/p.o.) and Gabapentin (300mg/kg/p.o.) started after last paclitaxel injection for next 4 weeks. Behavioral studies, thermal hyperalgesia, cold allodynia, mechanical allodynia and locomotor activity were conducted weekly using hot plate, cold plate, Von Frey filaments and actophotometer respectively. Motor nerve conduction velocity was performed by 8 channel power lab, biochemical studies and histopathological studies were performed using sciatic nerve homogenate at the end of the study. Results: Various doses of W. somnifera significantly reversed the behavioural, electrophysiological, biochemical and histopathological changes induced by paclitaxel in dose dose-dependent manner. Conclusion: The results indicate that W. somnifera exhibit antioxidant, analgesic and neuroprotective effects. This study indicated W. somnifera is beneficial to protect paclitaxel induced neuropathy and could be used as new therapeutic approach along with current medicines in the treatment of peripheral neuropathy.
Hydrogels, owing to their biocompatibility, tunable physical properties, and ability to retain moisture, have emerged as promising materials for dermatological applications. These gel-based systems provide innovative solutions for the treatment of various skin diseases, including wounds, burns, eczema, psoriasis, and microbial infections. This review explores the properties of hydrogels, their mechanisms of action, and their applications in skin disease therapies. Additionally, challenges and future perspectives in hydrogel-based treatments are discussed to highlight their potential in advancing dermatological care. Patients frequently seek both inpatient and outpatient medical care for skin infections. Skin infections are affecting more and more individuals worldwide, and they have the potential to cause both physical and mental harm. Because skin infections can present with a wide range of symptoms, doctors must diagnose them aggressively and accurately in order to prescribe the right symptomatic antibiotics. The majority of the time, oral or topical anti-infective medications are used to treat skin infections. However, some of the traditional anti-infective medications have drawbacks, like low bioavailability, poor targeting efficiency, and poor water solubility, which can result in side effects, drug resistance, and poor efficacy. Therefore, the creation of novel materials for more efficient drug delivery systems should be the main focus of research goals. One extremely versatile family of medical materials that may find use in dermatology is hydrogel. A number of anti-infective hydrogel dressings have been developed and shown to somewhat increase the effectiveness and tolerance of topical or oral traditional anti-infective medications. This paper provides a valuable theoretical reference for future research on skin infection treatment choices by methodically reviewing the medicinal applications of hydrogels for the treatment of diverse skin infections.
The increasing cost of health care requires an analysis that considers the aspect of economic efficiency in treatment. Gastritis is one of the diseases with a high prevalence that requires clinically effective and economically efficient therapy. This study aims to determine the minimum cost between the use of lansoprazole and omeprazole in hospitalized patients with gastritis at Dirgahayu Hospital Samarinda using the cost minimization analysis method. This study uses a pharmacoeconomic approach to identify alternative therapies with lower costs without reducing clinical effectiveness. In the pharmacoeconomic approach, the cost minimization analysis method is used to compare the costs of two health interventions that have equivalent clinical effectiveness. This study uses a quantitative study design with retrospective data collection and data are analyzed using cost minimization analysis to determine the minimum cost between the costs of lansoprazole and omeprazole treatment. Statistical methods are used to evaluate significant differences between groups. The sampling technique used is purposive sampling based on predetermined inclusion and exclusion criteria. The analysis includes fixed costs and variable costs. The results showed that patients with omeprazole therapy had the lowest cost with CMA per patient of IDR 2,495,987 compared to lansoprazole therapy with CMA per patient of IDR. 2,512,812 which had a relatively higher cost, however, there was no significant difference in the minimum cost between patients using omeprazole and patients using lansoprazole. The use of omeprazole and lansoprazole as gastritis therapy needs to be evaluated not only from a clinical perspective, but also in terms of cost efficiency. Through a cost minimization analysis approach, this study emphasizes the importance of choosing a therapy that provides clinical benefits equivalent to more economical expenditure in hospital health care practices.
