OBJECTIVE:By analyzing the signal mining of vandetanib AEs, it provides a reference for the rational clinical use of the drug. METHODS:This study provides signal detection and analysis of AEs associated with vandetanib using the FAERS from Q2 2011 to Q1 2023. RESULTS:Disproportionality analyses were conducted using the ROR and the MHRA method, with AEs categorized and described based on SOC and PT from the MedDRA. A total of 1,721 AEs reports identified vandetanib as the primary suspect. The analyses yielded 187 AEs signals across 20 SOCs categories, with 47 signals not previously reported in the vandetanib labeling. Additionally, the study analyzes factors influencing AEs. The results are as follows: There are significant differences in Investigations based on gender and nationality (p < 0.05); skin and subcutaneous tissue disorders and gastrointestinal disorders exhibit differences based on gender, age, and nationality (p < 0.05). CONCLUSION:Common AEs signals identified align with those documented in the drug labeling. However, AEs such as tumor lysis syndrome, skin discoloration, and pigmentary disorders, which are not listed in the labeling, warrant special attention. It is essential that abnormalities in patients' skin and laboratory indicators are closely monitored and addressed promptly to safeguard medication safety.
目的 调查慢性气道疾病患者稳定期干粉吸入装置吸入技术掌握情况,并分析其影响因素.方法 选取 2020 年1 月至 2020 年 12 月在常熟市第一人民医院呼吸与危重症医学科门诊就诊的慢性阻塞性肺疾病或哮喘患者 179 例,通过问卷评分的方法,对患者吸入技术掌握情况进行评估,分析4 种吸入装置的常见错误步骤,采用二元logistic回归分析吸入技术情况的影响因素.结果 55 例(30.7％)患者能完全正确掌握吸入技术,操作错误率前 3 位的步骤依次为:远离吸嘴,尽可能充分呼气(44.9％);将装置从嘴边移开,屏气 5～10 s后缓慢呼气(33.3％);用完吸入剂后及时漱口(29.5％).二元logistic回归分析显示,病程、依从性情况是慢性气道疾病患者吸入技术错误的影响因素(P<0.05).结论 慢性气道疾病患者干粉吸入装置吸入技术正确率较低,医务人员应规范吸入技术的随访路径,强化患者的吸入技术,以提高吸入装置操作的正确性.
Dendrobium has a long history of medicinal use. As a valuable medicinal material with the same medicinal and food sources, there is a phenomenon of confusion in the market. However, there are many kinds of medicinal dendrobium, and most of them belong to the same genus, which is difficult to identify. In this paper, traditional identification methods, chromatographic and spectral identification methods, molecular biological identification methods and others are summarized.There are limitations in the single identification method. It is suggested to establish a comprehensive and effective identification system and quality standard of dendrobium based on the characteristics, microscopic, chemical composition and gene sequence of dendrobium, so as to provide research ideas for the identification of medicinal dendrobium, with a view to ensuring drug safety.
目的 探讨二甲双胍联合阿卡波糖治疗2型糖尿病的临床价值.方法 纳入2021年1月至2023年1月莲花县人民医院收治的患者74例,均为2型糖尿病患者.随机数字表法分成两组各37例.对照组使用二甲双胍治疗,观察组在对照组基础上加用阿卡波糖.比较两组患者1个疗程后的临床疗效、服药期间不良反应情况以及治疗前后糖代谢指标、生活质量的变化情况.结果 观察组1个疗程后临床总有效率为94.59%,高于对照组的78.38%(P＜0.05);观察组服药期间不良反应总发生率为8.11%,高于对照组的5.41%(P＞0.05);观察组治疗后空腹血糖(FPG)、餐后2h血糖(2 hPG)、糖化血红蛋白(HbA1c)检测结果均低于对照组(P＜0.05);观察组治疗后躯体功能评分、心理功能评分、社会功能评分、物质生活状态评分均高于对照组(P＜0.05).结论 二甲双胍联合阿卡波糖治疗2型糖尿病疗效显著,安全性良好,能够明显改善患者的生活质量.
目的 探索临床药师对老年慢性阻塞性肺病患者实施药物重整的工作模式及效果,为基层药师实施药物重整工作提供参考.方法 将萍乡市人民医院 2021 年 5 月至 2022 年 5 月收治的老年慢性阻塞性肺病患者随机分为对照组和试验组.对照组按传统医疗模式治疗,试验组在传统医疗模式上,增加药物重整.比较两组患者药物不良反应/事件(ADR/ADE)发生率,慢性阻塞性肺疾病评估测试(CAT)评分,住院期间药品金额、药占比、总费用、住院天数以及住院患者满意度.结果 住院期间试验组与对照组相比,ADR/ADE发生率、药品金额以及药占比均更低(P＜0.05),患者满意度更高(P＜0.05),而总费用、住院天数以及出院CAT评分均差异无统计学意义(P＞0.05).结论 药物重整能进一步降低药品金额、药占比,可保障慢性阻塞性肺疾病患者用药安全,提高患者满意度,是基层临床药师为患者服务的重要模式.
