Objective To analyze the clinical value of painless manipulation in the treatment of children's dental diseases. Methods A total of 102 children with dental disease admitted from March 2020 to April 2021 were divided into two groups byrandom number table method. The control group（51 cases）received conventional local anesthesia with Artecaine, and theobservation group（51 cases）received combined general anesthesia with intravenous aspiration. The anesthetic treatment effect, treatment compliance, psychological state and pain of the two groups were compared. Results The effective rate of anesthesia inthe observation group was 94.12%, which was higher than that in the control group（74.51%, P＜0.05）; The painless rate of theobservation group was 68.63%, higher than that of the control group（37.25%）, and the SAS score of the observation group waslower than that of the control group（P＜0.05）; The treatment compliance of the observation group was 92.16%, higher than thatof the control group（72.55%）, with significant difference between the groups（P＜0.05）. Conclusion The painless treatmentwith intravenous inhalation combined with general anesthesia for children with dental diseases can effectively improve the anxiety ofthe children, reduce the degree of pain, improve their treatment compliance, ensure the successful completion of dental treatment forchildren, and improve the treatment effect. It has high application value.
目的 研究人体血清铁代谢异常与口腔念珠菌病之间的相关性。方法 收集 2020 年 8 月至 2021 年 8 月就诊于南京医科大学附属口腔医院口腔黏膜病科的 678 例患者的基本信息及实验室检查指标，统计患者念珠菌感染例数及感染阳性率，运用 SPSS 20.0 软件对收集的数据进行独立样本 t 检验分析。结果 678 例患者中，念珠菌培养阳性 156 例，阴性522 例，阳性率为 23.00%，其中女性培养阳性数为 102 例，男性感染例数为 54 例。念珠菌培养阳性组的血清铁蛋白和血清转铁蛋白水平明显低于阴性组，差异有统计学意义（P ＜ 0.05）。结论 人体血清铁代谢异常与口腔念珠菌的发病具有相关性，与其他的文献资料相符。
目的 探究牙周牙髓联合治疗与单纯牙周治疗对重度牙周炎疗效的对比。方法 选取 2021 年 1 月至 2021 年 9月收治的重度牙周炎患者为研究对象，筛选 60 例患者，按照随机数字表法分组，对照组 30 例，予以单纯牙周治疗，观察组 30 例，予以牙周牙髓联合治疗，观察牙周健康状况及总有效率。结果 治疗前两组重度牙周炎患者牙齿松动度（MD）、龈沟出血指数（SBI）、探诊深度（PD）、菌斑指数（PLI）指标比较，差异无统计学意义（P ＞ 0.05），治疗后两组 MD、SBI、PD、PLI 指标较治疗前降低，观察组指标低于对照组，差异有统计学意义（P ＜ 0.05）；重度牙周炎总有效率对比，观察组高于对照组，差异有统计学意义（P ＜ 0.05）。结论 牙周牙髓联合治疗重度牙周炎的效果优于单纯牙周治疗，获得更为理想的效果。
目的 对互动式 APP 教学平台在口腔护理教学中的应用效果进行探究。方法 选取 2019 年 7 月至 2020 年3 月 58 例护理专业学生作为研究对象，采用信封法将学生分为实验组和对照组，每组 29 例。实验组学生采用传统带教方式进行教学，对照组在传统教学基础上采用互动式 APP 教学平台辅助教学，然后对比两组的相关指标。结果 实验组教学满意度得分、理论成绩和实操成绩得分、活力评分、奉献评分、专注评分均高于对照组，差异有统计学意义（P ＜ 0.05）结论 对护理专业学生应用互动式 APP 教学平台辅助教学的效果显著，值得临床推广。
目的 探究开窗减压治疗口腔牙源性大型根尖周囊肿临床疗效。方法 2019 年 8 月至 2020 年 9 月，以医院收治的 60 例口腔牙源性大型根尖周囊肿患者为对象，随机分为两组，对照组采用常规根管治疗，观察组采用开窗减压治疗，比较两组患者的治疗效果、手术指标与疾病复发率。结果 观察组治疗总有效率大于对照组，差异有统计学意义（P ＜ 0.05）。观察组手术操作时间、囊肿愈合时间均短于对照组，观察组术中出血量少于对照组，观察组囊腔体积缩小率大于对照组，观察组术后疼痛评分低于对照组，差异有统计学意义（P ＜ 0.05）。观察组疾病复发率小于对照组，差异有统计学意义（P ＜ 0.05）。结论 口腔牙源性大型根尖周囊肿患者进行开窗减压治疗，手术效果较好，手术指标更优，疾病复发率更低，值得临床推广普及。
Objective To study the expression and distribution of SSB1 in submandibular gland of rats after radiation, andto explore the relationship between SSB1 and radiosensitivity of salivary glands. Methods The rat model of submandibular glandradiation injury was established in 2020, 40 adult rats were given a dose of 6Gy to irradiate the head and neck in a supine position. Fiverats were killed at random at an interval of 1 hour after irradiation. The submandibular gland was taken as the experimental specimen, forming eight experimental groups. Another 5 rats without irradiation were taken as the control group. Immunohistochemistry and RTqPCR were used to detect the expression of SSB1 in rat submandibular gland. Results SSB1 was mainly distributed in the nuclei ofserous cells, mucous cells and duct cells of submandibular gland. The expression of SSB1 in the un irradiated submandibular glandtissue also increased first and then decreased with time after 6 Gy irradiation, and then decreased to the normal level. Conclusion Theincreased expression of SSB1 induced by radiation is involved in the repair process of submandibular gland radiation injury, which maybe related to the radiosensitivity of salivary gland.
目的 探究口腔数字化技术在口腔修复临床的应用价值及安全性分析。方法 选取 2020 年 1 月至 2020 年 9月本院接收的口腔修复患者为观察对象，总计入组 60 例，遵循患者个人意愿，按照患者不同治疗方式分组，对照组采用传统技术进行口腔修复 30 例，试验组采用口腔数字化技术口腔修复患者 30 例，观察修复效果。结果 患者进行口腔修复治疗后，1 年内对照组患者不良事件发生率高于试验组（P ＜ 0.05）；评估口腔修复后色泽、形态及适合性，试验组牙齿色泽、形态及适合性评分高于对照组（P ＜ 0.05）；患者自评口腔修复满意度，试验组患者口腔修复后舒适度、义齿匹配度及美观度评分高于对照组（P ＜ 0.05）。结论 口腔修复采用口腔数字化技术可以获得更理想的修复效果，口腔修复后患者满意度高，具有临床推广意义。
Objective To study the clinical effect of vertical compression of hot dental glue combined with single apex iRootSP for non-surgical C-type root canals. Methods From January 2018 to October 2019, 360 non-surgical C-type root canal therapypatients were selected from the patients admitted to our hospital. They were randomly divided into a single group and a combinationgroup using a random number table method. The single group received hot gum vertical compression combined with Anplus rootcanal paste treatment（n=180）, while the combination group received hot gum vertical compression combined with iRoot SP singletip treatment（n=180）, and the efficacy of the two groups was compared. Results Before treatment, there were no differences ingingival index, periodontal pocket depth, plaque index and bleeding index between the two groups（P＞0.05）, but after treatment, the combined group was lower than the single group（P＜0.05）. Conclusion Non C root canal patients combined with iRootSP monopoetic root canal treatment can significantly improve the filling effect and improve the periodontal index, which is worthreference.
目的 探讨在慢性牙周炎治疗过程中采取西地碘含片联合透明质酸凝胶的临床治疗价值和影响。方法 研究时间为 2019 年 2 月至 2020 年 9 月，选取这个期间我院收治的 120 例慢性牙周炎患者，回顾性分析按照治疗方法分为试验组 60 例（西地碘含片联合透明质酸凝胶治疗）和对照组 60 例（西地碘含片），观察两组患者的临床治疗效果。结果 试验组治疗总有效率较对照组优异，差异有统计学意义（P ＜ 0.05）；治疗后，试验组心理功能、躯体功能、情绪功能、社会功能生活质量评分较对照组优异，差异有统计学意义（P ＜ 0.05）；试验组整体并发症发生率较对照组偏低，差异有统计学意义（P ＜ 0.05）；试验组出血指数、龈炎指数、菌斑指数较对照组优异，差异有统计学意义（P ＜ 0.05）；试验组整体治疗满意度较对照组优异，差异有统计学意义（P ＜ 0.05）。结论 在慢性牙周炎治疗过程中采取西地碘含片联合透明质酸凝胶，疗效显著，患者满意度高，并发症发生率低，治疗安全性高，可以在临床上进行推广。
目的 研究冰茶灵口腔护理治疗儿童疱疹性咽峡炎的临床疗效观察。方法 选取 2020 年 7 月至 2021 年 9 月云南省某三甲医院儿科门诊符合课题组纳入标准的患儿 78 例，按照随机数字表法，分为治疗组和对照组各 39 例。对照组患儿应用重组人干扰素 α1b1 注射液和辨证施护，治疗组患儿在对照组的基础上应用冰茶灵洗剂和冰茶灵洗剂口腔护理，比较两组的效果。结果 治疗组治疗后的中医症候积分低于对照组，差异有统计学意义（P ＜ 0.05）；治疗组患儿总有效率较对照组高，差异有统计学意义（P ＜ 0.05）。结论 冰茶灵洗剂口腔护理佐治儿童疱疹性咽峡炎疗效较好，值得临床推广应用。
目的 探讨在复发性口腔溃疡诊治中运用中医辨证疗法的临床效果，以指导临床，为相关研究提供可靠理论研究基础。方法 随机选择 2019 年 6 月至 2020 年 6 月期间于我院就诊且符合本次实验探究标准的 200 例复发性口腔溃疡病例，按照诊断治疗方式不同分成两组。第一组 100 例患者，定义为研究组，采用中医辨证治疗方法进行治疗干预。第二组 100 例患者，定义为对照组，采用常规西医治疗方法进行治疗干预。以治疗总有效性、疼痛严重程度、复发率、治愈时间等评估指标评价两种诊疗方式的治疗效果。结果 研究组患者治疗总有效率高于对照组，研究组患者预后疼痛 VAS 评分显著低于对照组，研究组治愈时间短于对照组，研究组复发率明显少于对照组，差异有统计学意义（P ＜ 0.05）。结论 中医辨证疗法治疗复发性口腔溃疡疗效肯定，能显著减轻病人痛苦程度，降低复发率，有临床使用意义。
目的 本次研究主要探讨口腔住院医师规范化培训中口腔颌面外科教学方法和效果。方法 随机选取 2020 年1 月至 2021 年 1 月时段内医院内口腔颌面外科 60 名医师为对象展开研究，并将医师分成对照组和研究组，对照组实施常规规范化培训，研究组在此基础上配合临床路径教学法进行培训，比较教学效果。结果 教学后，研究组理论考核、病例分析、临床技能等考核成绩均高于对照组，各项教学评价均高于对照组，差异有统计学意义（P ＜ 0.05）。结论 口腔住院医师规范化培训中针对口腔颌面外科教学可在常规培训教学基础上加以临床路径教学法，能够有效提高教学效果。
Objective To study and analyze the therapeutic effect of ultrasonic subgingival curettage and drug irrigation inpatients with periodontitis. Methods The 80 participants were all patients with periodontitis diagnosed and treated in our hospitalfrom December 2020 to September 2021, and were evenly divided according to the double-blind method, with 40 patients in eachgroup. The control group was treated with conventional ultrasonic subgingival cureage followed by irrigation treatment, while theexperimental group was treated with ultrasonic subgingival cureage combined with drug irrigation treatment. The cytokine indexes ofgingival crevicular fluid（PLI, BI, TNF-α, IL-6, IL-8）and the therapeutic effects of the two treatments before and after treatmentwere carefully observed and recorded in the two groups for comparative analysis. Results After treatment, the gingival crevicularfluid cytokine indexes（PLI, BI, TNF-α, IL-6, IL-8）of the experimental group were better than those of the control group, andthe differences were statistically significant（P＜0.05）. The therapeutic effect of the experimental group was better than that of thecontrol group, and the difference was statistically significant（P＜0.05）. Conclusion For patients with periodontitis, the treatmentof ultrasonic subgingival curetting and drug flushing has ideal therapeutic effect, which can effectively improve the cytokine indexlevel of gingival crevicular fluid, and is worth promoting.
Objective To study the effect of divided root canal therapy and one-off root canal therapy in pulpitis patients. Methods A total of 38 patients with pulpitis were selected from the Department of Stomatology of our hospital from September 2020to September 2021 were randomly divided into observation group（n=19）and control group（n=19）. The control group was treatedby fractional root canal therapy, while the observation group was treated by one-off root canal therapy, and the effect of two kindsof root canal therapy was evaluated. Results After treatment, the clinical effect of the observation group was higher than that of thecontrol group（P＜0.05）. The levels of C-reactive protein（CRP）, tumor necrosis factor-α（TNF-α）, interleukin-6（IL-6）andinterleukin-1β（IL-1β）in the observation group were lower than those in the control group（P＜0.05）. The pain score（VAS）ofthe observation group was lower than that of the control group at 3d and 7d after operation（P＜0.05）. The incidence of complicationssuch as occlusal pain, gingival swelling and infection in the observation group was lower than that in the control group（P＜0.05）. Conclusion In the treatment of pulpitis, although the divided root canal method and the one-time root canal method can play atherapeutic role, but the treatment effect of the one-time root canal method is better, which can effectively relieve inflammatory factorsand pain, and the treatment is safe and reliable, which is worthy of research and reference.
目的 探究成人双颌前突患者采用个性化舌侧矫正治疗的临床效果与治疗满意度。方法 随机选取我院 2020年 8 月至 2021 年 8 月收治的 72 例成人双颌前突患者作为研究对象，依据随机数字表法将患者平均分为对照组和观察组，对照组给予常规唇侧矫正治疗，观察组给予个性化舌侧矫正治疗，对比两组上、下中切牙角，切牙凸度，矫正满意度等。结果 两组患者治疗前上、下中切牙角，切牙凸度经对比，差异无统计学意义（P ＞ 0.05）；两组患者治疗后上、下中切牙角，切牙凸度经对比，差异有统计学意义（P ＜ 0.05）。观察组矫正满意度显著高于对照组，差异有统计学意义（P ＜ 0.05）。结论 成人双颌前突患者采用个性化舌侧矫正治疗，可以有效改善患者双颌前突症状，提高治疗效果，从而提高患者的矫正满意度。
Objective To analyze the therapeutic effect of early standardized swallowing function training in tongue cancerpatients repaired with free flap. Methods The study period was from June 2020 to May 2021, 53 patients with tongue cancer repairedby free skin flap were selected as the subjects of this clinical trial design. They were divided into groups by random number table, and all patients with tongue cancer repaired by free skin flap were divided into groups. Among them, 27 patients in the control groupreceived routine rehabilitation training, and 26 patients in the observation group received early standardized swallowing functiontraining after routine rehabilitation training. The swallowing function, swallowing muscle and quality of life were compared betweenthe two groups. Results There was no significant difference in swallowing function scores between the two groups before treatment, 2 months and 3 months after operation（P＞0.05）. The swallowing function score of the observation group was significantly lowerthan that of the control group 2 weeks after operation（P＜0.05）. 57.69% of tongue muscle in the observation group was significantlyhigher than 25.93% in the control group（P＜0.05）. Conclusion Early standardized swallowing function training can promote therecovery of swallowing function and improve swallowing muscle function.
目的 系统评价 iRoot BP Plus 与三氧化矿物聚合体（MTA）用于显微根尖手术治疗的临床效果。方法 电子检索中国生物医学文献数据库、中国知网、Medline、EMBASE 和 PubMed 等数据库，检索时间截至 2020 年 8 月，采用Cochrane 协作网推荐的方法进行质量评价，文献筛选并提取数据后采用 RevMan 5.4 进行 Meta 分析。计算比值比（OR）或均值差（MD）和 95% 可信区间（CI）。结果 最终纳入 9 个随机对照试验。Meta 分析显示，与 MTA 相比，iRoot BP Plus用于显微根尖手术成功率略高，差异无统计学意义［OR 合并为 1.12，95%CI（0.58，2.16），P=0.74］。iRoot BP Plus 用于显微根尖手术倒填充的术后 1 周肿痛率（10.30%）低于 MTA 用于显微根尖手术倒填充的术后 1 周肿痛率（21.8%），差异有统计学意义［OR 合并为 0.41，95%CI（0.21，0.82），P=0.01］；6 个月后的 PAI 指数变化对比，随机效应模型 Meta 分析结果显示，对应时间点内 MTA 组低于 iRoot BP Plus 组，差异有统计学意义［MD=0.19，95%CI（0.12，0.25），P ＜ 0.00001］。结论 iRoot BP Plus 与 MTA 对显微根尖手术均可达到较好的倒充填材料的封闭作用，但与 MTA 相比，iRoot BP Plus 在术后肿痛率、根尖周变化等方面具有一定的优势，是更为理想的显微根尖手术倒填充材料。
Objective To analyze the efficacy of ornidazole combined with minocycline in the treatment of periodontal pulpsyndrome. Methods 80 patients with periodontal pulp syndrome treated in our hospital from January to October 2021 were randomlydivided into reference group（n=40, oral administration of minocycline capsule and ornidazole dispersible tablets, sealing calciumhydroxide in root canal after root canal preparation）and study group（n=40, root canal administration of ornidazole combined withminocycline）. The clinical efficacy, periodontal health index, bacterial clearance and adverse reactions were compared. Results Thetreatment effect and infection clearance of the study group were higher than that of the control group, and the periodontal health indexof the treated patients were lower than that of the control group（P＜0.05）. Conclusion The treatment of ornidazole combined withminocycline through root canal can significantly improve the periodontal health index and high bacterial clearance rate. It is an idealand safe treatment scheme.
Objective The specific clinical manifestations of oral submucosal fibrosis were analyzed in a comparative way. Methods 40 patients with oral submucous fibrosis admitted in 96605 Military Hospital of People's Liberation Army from June 2019to September 2021 were selected as the observation group, and 40 normal persons were selected as the control group. The periodontalhealth of the two groups was evaluated to provide valuable countermeasures for prevention, control and treatment of the disease. Results After evaluation, the plaque index and periodontal probing depth in the observation group were significantly different fromthose in the control group（P＜0.05）; There was no significant difference between the two groups in clinical attachment loss, gingivalindex, and number of teeth bleeding on exploration（P＞0.05）. Conclusion In patients with oral submucous fibrosis, plaqueaccumulation is widespread, which may aggravate periodontitis.
目的 探讨单纯牙周治疗与牙周牙髓联合治疗对重度牙周炎的疗效。方法 回顾性选取 2020 年 1 月至 2021年 9 月苏州口腔医院综合科重度牙周炎患者 100 例，依据治疗方法分为观察组（牙周牙髓联合治疗）、对照组（单纯牙周治疗）两组，每组 50 例。分析两组患者牙周指标、牙周组织基质金属蛋白酶（MMP）、松动度、骨密度指标、放射性指标、临床疗效、满意度。结果 治疗后观察组患者的牙周袋探诊深度（PPD）、相对附着水平（PAL）、龈沟出血指数（SBI）、菌斑指数（PI）均低于对照组（P ＜ 0.05）。治疗后观察组患者的牙周组织 TIMP-1 水平高于对照组（P ＜ 0.05），MMP-1、MMP-8、MMP-13 水平均低于对照组（P ＜ 0.05）。治疗后观察组患者的牙齿松动度、釉牙骨质界到牙槽嵴顶距离（CEJáC）、釉牙骨质界到骨缺损底距离（CEJ-BD）均低于对照组（P ＜ 0.05），骨密度指标（CADIA）高于对照组（P ＜ 0.05）。观察组患者的总有效率高于对照组（P ＜ 0.05）。观察组患者的满意度高于对照组（P ＜ 0.05）。结论 牙周牙髓联合治疗重度牙周炎的疗效较单纯牙周治疗显著。
