Objective:To observe the clinical efficacy of modified Shaoyao Gancao Decoction in the treatment of autoimmune hepatitis(AIH)of liver-kidney Yin deficiency type.Methods:A total of 78 AIH patients with liver-kidney Yin deficiency type diagnosed in the Department of Hepatology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from February 2020 to March 2023 were selected.After removing the shedding cases,a total of 74 patients were divided into two groups according to random number table method(39 cases in the treatment group and 35 cases in the control group).The patients in the treatment group were given modified Shaoyao Gancao Decoction and the patients in the control group were given compound glycyrrhizin tablets.The treatment lasted for 12 weeks.The evaluation criteria of comprehensive efficacy and the improvement rate of TCM syndrome scores were the main efficacy indexes,and the changes of alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyltransferase(GGT),globulin(GLB)and immunoglobulin(IgG)antibody levels from baseline were the secondary efficacy indexes.Results:Based on the evaluation index of western medicine,the total effective rate of the treatment group was 94.87%,and the total effective rate of the control group was 65.71%.Based on the improvement rate of TCM syndrome scores,the total effective rate was 94.87%in the treatment group and 57.14%in the control group.GLB after treatment was lower than that before treatment in both groups,and GLB after treatment in the treatment group was lower than that in the control group.The difference was statistically significant(P<0.05).IgG in the treatment group was lower after treatment than that before treatment,and there was no statistical significance in the control group before and after treatment(P>0.05).ALT,AST and GGT were all lower after treatment,but there was no statistical significance between the two groups(P>0.05).No adverse reactions were observed in both groups during treatment.Conclusion:Modified Shaoyao Gancao Decoction can relieve the clinical symptoms of AIH patients with liver-kidney Yin deficiency type,reduce the levels of GLB and IgG,and restore the liver function of patients.And it has long-term stability and safety.Its effect is better than oral compound glycyrrhizin tablets.
According to the theory of"holism of body and spirit"in Chinese medicine,tic disorder belongs to the comorbid medical conditions of"body"and"spirit".Tic disorder damages both body and spirit,and the key lies in the disharmony of heart and spleen.Treatment based on the heart and spleen,the main clinical acupoints along the governor vessel,pericardium channel,spleen and stomach channels are taken to regulate the heart and spleen,as well as body and spirit,which achieves ideal clinical effect.In the practice of acupuncture and moxibustion,we should pay attention to regulating Qi activity and keeping spirit inside.The effect of acupuncture depth and reinforcing and draining on curative effect should be valued.In clinical practice,we can also flexibly take auxiliary methods such as electroacupuncture and press-needle according to the actual condition.According to the different types and onset periods of tic disorder,the body and spirit should be regulated with emphasis.
Venous leg ulcer is a common disease in TCM surgery,which has complex etiology and is difficult to heal.Di-rector Zheng Xuejun,a famous traditional Chinese medicine doctor in Shanxi Province,believes that the key to the pathogenesis of this disease is the toxicity transformed by the accumulated heat from the dampness and stasis stagnated in the vessels over time.The internal treatment is"regulating blood to alleviate water retention and removing blood stasis to dredge collateral".Self-designed Vein Prescription I is the basic formula,and the formula can be modified according to different syndromes in different stages(dampness and stasis blocking collaterals syndrome in the early stage of ulcer,accumulated dampness,heat and stasis syndrome in the stage of ulcer,and root-deficiency combined with pathogenic factors lingering on in the healing stage).The external treatment is based on the principle of"removing slough and promoting the growth of tissue regeneration",and uses a new method to refine Hongsheng Dan.The self-made improved Shengji Yuhong oil yarn is externally used for wound surface.Traditional Chinese medicine fumigation and washing method is used in each stage and dampness-drying detoxification lotion and ulcer lotion are often used for fumigation and washing and promoting the growth of tissue regeneration.Binding therapy is used extensively to promote venous return and reduce lower limb edema.During different therapies,the assistance of the internal and external treatments and the combination of the Chinese and the western medicine have a very good effect.Through the anal-ysis of director Zheng Xuejun's understanding of venous leg ulcer and the experience of medication rules,this paper summarizes his clinical experience and inherits academic thoughts.And a case is attached for reference.
Objective:To explore the clinical curative effect of modified Niubang Jieji Decoction in the treatment of facial allergic dermatitis.Methods:From August 2021 to August 2022,62 patients with facial allergic dermatitis admitted to the Department of Dermatology of the First Affiliated Hospital of Anhui University of Chinese Medicine were selected as the research objects.The patients were divided into the control group and the study group by random number table method,with 31 cases in each group.The patients in the control group took desloratadine citrate disodium tablets,and the patients in the study group took modified Niubang Jieji Decoction on the treatment basis of the control group.The clinical curative effect,symptom score,inflammatory index and immune function of the patients in both groups were observed.Results:The clinical curative effect of the study group was better than that of the control group,and the difference was statistically significant(P<0.05);after treatment,the symptom scores of redness and swelling,papules,exudation/erosion,pruritus,desquamation and other inflammatory factors[C-reactive protein(CRP),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)]in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05);the improvement of immunoglobulin G(IgG),immunoglobulin A(IgA)and immunoglobulin M(IgM)in the study group was greater than that in the control group,and the differences were statistically significant(P<0.05).Conclusion:The treatment of facial allergic dermatitis with modified Ni-ubang Jieji Decoction can improve the immune function of patients,reduce the inflammatory response,and relieve symptoms,which has reliable curative effect.
Objective:To explore the medication rules of professor Lu Bingjiu in the treatment of ascites due to liver cirrhosis(meteorism)with spleen and kidney Yang deficiency syndrome by data mining method.Methods:A retrospective analysis method was used to collect 103 patients with ascites due to liver cirrhosis with spleen and kidney Yang deficiency syndrome diagnosed and treated by Prof.Lu Bingjiu,a famous traditional Chinese medicine doctor in Liaoning Province,with significant curative effect from December 1,2020 to December 1,2022.Excel 2019,SPSS 25.0,SPSS Modeler 18.0 and other software were used to conduct drug frequency statistics,nature,flavor and channel tropism analysis,association rule analysis,cluster analysis and disease etiology analysis.Results:102 Chinese herbs were involved.The drug nature and flavor were mostly sweet and warm,and the channel tropism was mostly spleen channel and stomach channel.Deficiency-tonifying drugs,damp-clearing and diuresis-promoting drugs,and Qi-regulating drugs were commonly used.The common drug combinations were Fuling-Chenpi,Fuzi-Cheqianzi,Jineijin-Haipiaoxiao,Xueyutan+Diyutan-Haipiaoxiao.The core ingredients were:Ren-shen,Fuzi,Guizhi,Baizhu,Fuling,Zexie,Dafupi,Chenpi,Shanzha,Maiya,Shenqu,Tinglizi,Chushizi,Cheqianzi,Xueyutan,Diyutan and Haipiaoxiao.Four cluster prescriptions were obtained by cluster analysis,namely,Tongda Xiaoji Prescription,Dampness-removing and Spleen-promoting Prescription,Qi-blood-tonifying Prescription,and Spleen-strengthening and Lung-controlling Prescription.Conclusion:In the treatment of patients with ascites due to liver cirrhosis with spleen and kidney Yang deficiency syndrome,Master Lu focuses on warming Yang and invigorating spleen,strengthening spleen and controlling lung,and supplements with the drugs to remove blood stasis and stop bleeding,remove food masses and harmonize stomach,and invigorate Qi and generate blood.The overall characteristics of drug use can be summarized as the combined regulation of Yin and Yang,spleen-strengthening and lung-controlling,preventing disease from exacerbating and combination of tonification and promotion.
Degenerative lumbar spinal stenosis(DLSS)is a common spinal disease,affecting middle-aged and elderly people.In recent years,the incidence of the disease has increased year by year and has a trend of younger people,so that the quality of life of patients has been seriously decreased.The disease is serious and needs to be solved.Tracing the origin of this disease,it is caused by the deficiency of kidney essence and the stasis of governor vessel,which belongs to the syndrome of deficiency in origin and excess in superficiality.The treatment takes tonifying kidney as the core and dredging governor vessel as the means.In the acupuncture method of"strengthening kidney and dredging governor vessel",the main acupoints are Shen-shu,Mingmen and Weizhong,and the matching acupoints are bilateral waist Jiaji(L3-L5),Houxi,Huantiao,Yanglingquan,Chengshan and Xuanzhong.Through tonifying kidney,dredging governor vessel and nourishing the tendons and vessels,Qi of Yang channel can be dredged,which can achieve both treatment of origin and superficiality and the purpose of curing the disease.By summarizing the clinical experience of"strengthening kidney and dredging governor vessel"acupuncture in the treatment of DLSS,we hope to further improve the clinical effect.
Chronic fatigue syndrome is characterized by long-term sustained fatigue and difficulty to recover after rest.In addition to fatigue,patients also commonly experience changes in mental state(such as depression,anxiety and other symptoms),decreased sleep quality,and even a series of accompanying symptoms that seriously affect the quality of life,such as muscle soreness,headache,sore throat and joint pain.In recent years,the incidence of the disease has increased year by year,but most of the clinical examinations have no organic lesions,so the scale is used as the main method of diagnosis and detection of treatment effect.There are some problems such as unclear selection criteria in the process of using the scale.In order to make the direction of using the scale clearer and the selection more standardized in the future,this study analyzes the evaluation effect of different categories of scales for evaluating chronic fatigue syndrome.
Type 2 diabetes mellitus belongs to the categories of"pidan"and"xiaoke"in traditional Chinese medicine.The theoretical understanding of traditional Chinese medicine in the prevention,treatment and rehabilitation of type 2 diabetes mellitus is comprehensive,and the clinical effect is significant.The constitution theory of"three-Yin and three-Yang"originates from Shanghan Lun(Treatise on Febrile Diseases).Professor Zhao Jinxi summarizes the physiological functions of the six major systems of the human body,and divides type 2 diabetes mellitus into 13 types of common types,so as to form a trinity of treatment ideas of"differentiation of constitution,differentiation of disease and differentiation of syndrome".The theory of"over-exuberant fire consuming Qi"in Huangdi Neijing reflects the loss of healthy Qi is caused by pathological fire.In view of over-exuberant fire and consumption of Qi,Prof.Zhao Jinxi analyzes the basic pathogenesis of"fire-heat consuming Qi"of type 2 diabetes mellitus from six aspects:disease location,disease nature,microcosm,syndrome,evolution and progress.Based on the theory of"three-consumption",traditional Chinese medicine believes that the core disease location of type 2 diabetes mellitus is in the lung,stomach and kidney,while Prof.Zhao Jinxi believes that spleen,stomach,liver and kidney are the core sites of type 2 diabetes mellitus.The main treatment is to clear heat,tonify Qi and nourish Yin.In clinical practice,the coordination of multiple viscera and organic holism should be taken into consideration.Prof.Zhao Jinxi treats type 2 diabetes mellitus based on the"three-Yin and three-Yang","over-exuberant fire consuming Qi"and"spleen,stomach,liver and kidney",and has formed a relatively rich experience in diagnosis and treatment,which has a wide range of application value for improving the clinical efficacy of type 2 diabetes mellitus.
Objective:To provide a better treatment method for knee osteoarthritis(KOA)based on TCM syndrome differentiation after discussing the TCM syndrome differentiation,treatment method,classification after syndrome differentiation and acupoint selection without syndrome differentiation.Methods:The literature related to acupuncture and moxibustion for KOA was retrieved from China National Knowledge Infrastructure(CNKI),VIP Chinese Science and Technology Journal Database,Wanfang Data Knowledge Service Platform and other databases from January 2012 to August 2022.Excel 2021 was used to summarize the data and construct an acupuncture prescription database.Aprior algorithm in SPSS Modeler 18.0 statistical analysis software was used to conduct association rules analysis of acupoints,and SPSS 26.0 statistical software was used to perform cluster analysis of acupoints.Results:A total of 381 articles were included,385 acupuncture prescriptions and 76 acupoints were obtained,and the total frequency of acupoints use was 2530 times.The eight most commonly used acupoints in the treatment of KOA with acupuncture in clinical practice were Neixiyan,Dubi,Yanglingquan,Yinlingquan,Heding,Xuehai,Liangqiu and Zusanli.The most commonly used meridians were the stomach meridian of foot-yangming,extra nerve points and the spleen meridian of foot-taiyin,and the selected acupoints were concentrated in the lower limbs.Association analysis showed that the 8 core acupoints of different syndrome types(cold-damp obstruction type,liver-kidney deficiency type,Qi stagnation and blood stasis type and unclassified type)were Neixiyan,Dubi,Yanglingquan,Yinlingquan,Heding,Xuehai,Liangqiu and Zusanli.Two groups of core prescriptions of KOA with different syndrome types were obtained by cluster analysis(cold-damp obstruction type,liver-kidney deficiency type,Qi stagnation and blood stasis type and unclassified type),among which the eight acupoints of Neixiyan,Dubi,Yanglingquan,Yinlingquan,Heding,Xuehai,Liangqiu and Zusanli were most connected.Conclu-sion:Although there are differences in acupoint selection in acupuncture-moxibustion prescriptions(for example,Ganshu and Shenshu are selected for liver-kidney deficiency type;Xiyangguan is selected in cold-damp obstruction type;Geshu is selected in the type of Qi stagnation and blood stasis),but the frequency of selection and the difference are small.
Objective:To explore the effect of acupuncture therapy combined with auricular point sticking,muscle stretch and moxibustion on the efficacy and negative emotion of patients with cervical myofascial pain syndrome.Methods:A total of 80 patients with cervical myofascial pain syndrome admitted to the Department of Rehabilitation Medicine,National Hospital of Guangxi Zhuang Autonomous Region from June 2021 to December 2022 were selected and divided into control group and obser-vation group according to envelope method,with 40 cases in each group.The patients in the control group were given acupuncture therapy and routine nursing,and the patients in the observation group were given auricular point sticking combined with muscle stretch and moxibustion on the treatment basis of the control group.Numerical rating scale(NRS)was used to evaluate the pain of the patients in two groups before intervention,at 24 h,the third and seventh day of intervention,respectively.The negative emotions of the patients in two groups were assessed by self-rating Anxiety Scale(SAS)and self-rating Depression Scale(SDS)before and after intervention,respectively.Neck motion was assessed before and after intervention,and the recurrence of cervical myofascial pain in the patients in two groups was followed up by telephone 6 months after discharge.Results:The pain scores of patients in the two groups were compared in time effect,intergroup effect and interaction effect,and the differences were sta-tistically significant(P<0.001);after intervention,the negative emotion and range of neck motion in the observation group were significantly better than those in the control group,and the difference was statistically significant(P<0.001);the recurrence rate of medial neck myofascial pain in the observation group was significantly lower than that in the control group 6 months after discharge,and the difference was statistically significant(P<0.05).Conclusion:Acupuncture therapy combined with auricular point sticking,muscle stretching and moxibustion can effectively relieve pain,improve negative emotions,improve neck mobility and reduce recurrence rate,which is helpful to improve the clinical efficacy of patients with cervical myofascial pain syndrome.
Objective:To analyze the factors of TCM syndrome types of 861 patients infected with Omicron variant of novel coronavirus in Anhui Province from December 19,2022 to December 27,2022 and explore the rules of TCM syndrome types.Methods:The clinical data of infected persons were collected through platforms such as Sojump and Tencent Documents to establish a database.IBM SPSS Statistics 25 platform was used to mine the above data with association rules,cluster analysis and factor analysis,and analyze the TCM syndrome types characteristics of patients infected with the Omicron variant of the nov-el coronavirus.Results:There were 7 kinds of TCM syndrome types,including epidemic toxin attacking the exterior,stagnated cold-dampness in the lung,accumulated dampness-heat in the lung,stagnated dampness-toxin in the lung,the combination of epidemic toxin and dryness,both deficiency of lung Qi and spleen Qi,and both deficiency of Qi and Yin.Association rules showed that aversion to cold and chills were more likely to occur at the same time than other symptoms.Cluster analysis involved 7 disease nature elements(superficial cold,stagnated heat,cold dampness,damp-heat,Qi deficiency,Yang deficiency,and Yin deficiency)and 6 disease location elements(lung,spleen,stomach,liver,gallbladder,and kidney).Factor analysis involved 7 disease nature elements(superficial cold,stagnated heat,cold-dampness,dampness-heat,Qi deficiency,Yang deficiency,and Yin deficiency)and 7 disease location elements(lung,spleen,stomach,liver,gallbladder,kidney,and large intestine).Cluster analysis and factor analysis derived similar conclusions,reflecting the nature of the novel coronavirus infection.Conclusion:The main cause of infection of the novel coronavirus is coldness,which is mixed with dampness,and has the characteristics of damaging Yang and consuming Qi,and attacking the exterior to transform into heat.The disease nature is characterized by the mixture of deficiency and excess,and the disease location is mainly in the lung and spleen,as well as involving the stomach,liver,gallbladder,kidney and large intestine.The main types of syndrome are stagnated cold-dampness in the lung and epidemic toxin attacking the exterior.
Objective:To explore the mechanism of Chiyin Mixture in treating cholestatic hepatitis based on network pharmacology and molecular docking.Methods:The effective components and corresponding targets of Chiyin Mixture were obtained by TCMSP platform,and the disease targets of cholestatic hepatitis were obtained by GeneCards and OMIM database.According to the STRING database and Cytospace 3.0.1 software,the effective component-disease intersection target protein interaction network was constructed.The GO function and KEGG pathway enrichment were analyzed in the DAVID database.TCMSP,PubChem,UniProt,PDB platform and Chem 3D software were used to obtain the 3D structure of receptors and ligands,and AutoDock Vina and PyMoL software were used to perform molecular docking and visual analysis.Results:There were 365 targets of Chiyin Mixture,255 targets of cholestatic hepatitis,and 18 targets of their intersection.The functional analysis of GO showed that its mechanism of action may be closely related to 31 biological processes such as exogenous stimulus response,positive regulation of gene expression,and identical protein binding,17 cellular components such as extracellular space,plasma membrane,and components of the plasma membrane,and 38 molecular functions such as protein binding,identical protein binding,and enzyme binding.Enrichment analysis of KEGG pathway showed that it was closely related to NF-κB signaling pathway,Toll-like receptor signaling pathway and PI3K/Akt signaling pathway.Molecular docking showed that RAF1 might be an important target of Chiyin Mixture for the treatment of cholestatic hepatitis.Conclusion:Traditional Chinese medicine compound has multi-component,multi-target and multi-pathway therapeutic effects.Chiyin Mixture may treat cholestatic hepatitis through anti-inflammatory and antioxidant mechanisms.
Objective:To measure the skin microcirculatory blood perfusion units(MBPU)in the neck and back in cervical spondylosis patients by laser speckle skin perfusion imaging technique,and to summarize the characteristics of skin microcirculation perfusion in tenderness sensitization areas related to cervical spondylosis after compareing with healthy sub-jects.Methods:The MBPU in the neck and back skin and data of 35 patients with cervical spondylosis and 30 healthy subjects were measured and analyzed.The skin MBPU characteristics of upper cervical region(C2～C5 level),lower cervical region(C6～C7 level)and dorsal region(T1～T3 level)were compared between the two groups.Results:In both groups,the average MBPU of upper cervical region was higher than that of lower cervical region and dorsal region,and the average MBPU of upper and outer cervical region was higher than that of upper and inner cervical region,with statistically significant difference(P<0.01).In the cervical spondylosis group,the difference between high and low MBPU in the upper cervical region was significantly higher than that in the lower cervical region and the dorsal region(P<0.01).Compared with the healthy group,the average MBPU of the upper cervical region and the upper and outer cervical region in the cervical spondylosis group increased(P<0.05).Con-clusion:The upper cervical region in cervical spondylosis has the characteristics of high MBPU and large drop of MBPU,which can provide reference for the localization of cervical spondylosis sensitization site.The characteristics of high MBPU in the upper and outer cervical region can provide more accurate location of the sensitization site of cervical spondylosis,and provide experimental basis for clinical precise treatment with acupuncture and moxibustion.
整复手法治疗腰椎疾病疗效确切,从整复手法的发展历程、整复手法治疗腰椎疾病的诊治理论、整复手法治疗腰椎疾病领域新的研究等角度着手阐明中医整脊与美式整脊手法的传承及特色.腰椎疾病与人类生产生活长期伴随,中医整脊与美式整脊手法在腰椎疾病治疗领域各有所长,在临床过程中要辨证辨病应用,既要做到"点-线-面"结合(背部腧穴与脊柱周围病灶点-背部的经络-背部肌肉整体),也要精准击破特殊问题,如寻找引发腰痛的相应腰椎结构病变部位、病变腰椎结构间构成的空间半脱位关系、患者病变腰椎的空间位置与手法操作者操作部位之间达成的力学条件等,做到灵活使用手法.
甲状腺相关性眼病(TAO),又称格雷夫斯(Graves)眼病,是一种以眼球突出、结膜水肿、眼睑退缩、眼球运动障碍、视力下降等为临床特点的自身免疫性疾病.由于本病的发病机制尚不完全清晰,治疗方法各异,多采用糖皮质激素冲击治疗、放射治疗及其他辅助治疗,但不良反应的问题不可忽视.中医在治疗上秉持辨证论治的观点,采用中药汤剂、针灸等多种治疗方式,显示出特有优势.目前,中医药对于甲状腺相关性眼病的辨证分型、分期还未做出统一标准,中药组方的作用机制尚在探索,应建立相关动物模型,进行相关的动物实验研究,以期为临床开展相关工作提供参考.
Dysphagia in the posterior pharyngeal phase after stroke is caused by the hypofunction of mental activity due to impairment of head collaterals,and the failure of spirit to restrain Qi.Obstructed and nonnutritive Qi and blood in the channels and tendons in the throat can make the disease appear.The conditions of body shape,spirit and disease nature at different stages of the course of the disease are different,and the treatment should also be different.Acupotomy treatment has a good effect on improving circulation and anti-muscular atrophy fibrosis.According to the characteristics of the course of the disease,the targeted treatments of regulating spirit to restrain Qi in acute stage,co-regulating of body and spirit in the recovery stage and recovering body shape and communicating spirit in the sequelae stage are formed by staging releasing the suboccipital muscle group and subohyoid muscle group.This meets the practical clinical needs,and can provide some references for the treatment of swallowing disorders in the posterior pharyngeal stage after stroke.
Persistent postural perceptual dizziness(PPPD)has been diagnosed in recent years.The pathogenesis of PPPD is still unclear,and the treatment options of Western medicine are limited.According to its clinical symptoms,it can be classified into the categories of"depression"and"vertigo"in traditional Chinese medicine.Professor Xie Daojun believes that PPPD is caused by liver and spleen dysfunction due to various reasons.The failure of liver to dredge and disperse and invigoration of spleen to transport can make retention of water fluid and generation of phlegm and dampness.The main treatment is soothing the liver and invigorating the spleen.The prescription is modified combination of Banxia Baizhu Tianma Decoction and Wendan Decoction.After many years of clinical application,the effect is very good,and the recurrence rate of patients is low.
Objective:To explore the clinical efficacy and safety of Zishen Shugan Decoction in the treatment of peri-menopausal sleep disorder with kidney deficiency and liver depression syndrome.Methods:80 patients with perimenopausal sleep disorder were randomly divided into observation group and control group,with 40 cases in each group.The patients in the control group took zopiclone capsules,and the patients in the observation group took Zishen Shugan Decoction on the treatment basis of the control group.The patients in both groups were treated for 4 weeks.The changes of Pittsburgh sleep quality index(PSQI)score,TCM syndrome(TCMS)score,serum estradiol(E2)and follicle-stimulating hormone(FSH)levels before and after treatment were observed in two groups.Polysomnography(PSG)was used to analyze total sleep time(TST),sleep efficiency(SE),sleep latency(SL)and awakening times(AT).Results:①Compared with those before treatment,the serum FSH level,PSQI score and TCMS score in the two groups after treatment were decreased,the E2 level was increased,and the differences were statistically significant(P<0.01).The difference between the two groups after treatment was statistically significant(P<0.01),and the observation group was significantly better than the control group.② In PSG indexes,the TST was prolonged,SE was increased,SL was shortened,and AT were decreased in the treatment group after treatment,and the differ-ences were statistically significant compared with those before treatment(P<0.01).In the control group,SE was increased,SL was shortened and AT was decreased after treatment,and the differences were statistically significant compared with those before treatment(P<0.05,P<0.01);TST was prolonged,but there was no statistical significance compared with that before treatment.There was statistical significance in TST,SE and SL between the two groups(P<0.05,P<0.01);there was no statistical significance in AT between the two groups.Conclusion:Zishen Shugan Decoction can improve the clinical symptoms of patients with perimenopausal sleep disorder with kidney deficiency and liver depression syndrome,with good curative effect and safety.
Objective:To explore the medication rules of Chinese herbs in the treatment of Crohn's disease(CD)and the potential mechanism of core drug combination by data mining and network pharmacology technology.Methods:Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical Literature Database,Wanfang Knowledge Service Platform and VIP Chinese Periodical Database(VIP)were searched for the literature on the treatment of CD with Chinese herbs.Microsoft Excel 2019 and SPSS Modeler 18.0 were used to conduct drug category,frequency of property,flavor and channel tropism,association rules analysis,and cluster analysis to refine the core drug combinations.Network pharmacology was used to screen and predict the potential core targets of drug active ingredients in the treatment of CD,and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis was performed to explore their specific mechanisms of action.Finally,molecular docking technology was used to reversely verify the key components and core targets.Results:A total of 114 prescriptions were obtained from the database,involving 181 Chinese herbs,of which 10 herbs were used more than 34 times;the drug categories were mainly tonifying deficiency drugs,clearing heat drugs,and clearing dampness and promoting diuresis drugs;the medicinal properties(four properties)were mainly warm,mild and cold,the medicinal flavors(five flavors)were mainly sweet,bitter and pungent,and the channel tropism was mainly spleen,stomach,lung and liver channels;15 high-frequency drug pairs were obtained by association rules analysis,and 4 drug combinations were obtained by cluster analysis.The active ingredients in the core drugs"Dangshen-Huangqi-Baizhu-Fuling-Gancao"combination included quercetin,kaempferol,luteolin,7-0-isoproxanol methyl,7-methoxy-2 methyl isoflavone,etc.They acted on 7 core targets,such as tumor protein p53(TP53),signal transducer and activator of transcription 3(STAT3),serine/threonine kinase 1(AKT1),mitogen-activated protein kinase 3(MAPK3),RELA proto-oncogene(RELA),mitogen-activated protein kinase 1,and FOS proto-oncogene(FOS),involving phosphatidylinositol 3 kinase/protein kinase B(PI3K-Akt),T helper cell 17 differentiation,cancer,interleukin-17,tumor necrosis factor and other signaling pathways.The results of molecular docking showed that the first 5 active ingredients had good docking effect with the first 4 targets.Conclusion:Chinese herbs for CD mainly focuses on tonifying deficiency and expelling pathogenic factors,invigorating spleen,tonifying lung and promoting diuresis,supplemented by clearing heat,drying dampness and warming Yang,which emphasize the combination of root cause and the manifestations.The potential mechanism of the core drug combination"Dangshen-Huangqi-Gancao-Baizhu-Fuling"is related to the regulation of inflammation,cell apoptosis and proliferation,oxidative stress and so on.
近年来,随着电子设备的普及,颈椎病的发病率逐年上升,其中颈型颈椎病发病率最高,作为颈椎退行性病变的初期阶段,该病具有症状轻、范围局限等特点,及时治疗可避免其他类型颈椎病的发生.通过对近5年来国内外针刺治疗颈型颈椎病文献的归纳整理发现,针刺治疗颈型颈椎病方法多样,应用广泛,临床疗效确切,以普通针刺为主,并涉及电针、火针、穴位埋线、针刀等多种疗法,具有"简、便、廉、验"等优势,就其选穴及操作进行总结分析,以期为临床进一步研究治疗颈型颈椎病提供思路与方向.
