通过查阅近年来国内外相关文献，从骨缺损传统治疗方法、骨搬运的应用、载抗生素硫酸钙的应用及优缺点方面进行总结载抗生素硫酸钙联合骨搬运治疗开放性骨折及骨感染的研究进展，载抗生素硫酸钙联合骨搬运技术能够较好地治疗骨感染及骨缺损，未来需要更多高质量临床研究进一步探索该并发症防治措施，并评估获得的临床效益。
Objective:To investigate the relationship between serum levels of S100 calc-binding protein A12(S100A12), forkhead box F1(FOXF1), glucagon-like peptide-1(GLP-1)and disease severity in elderly patients with coronary atherosclerotic heart disease(CHD).Methods:This study was a case-control study, a total of 145 elderly CHD patients admitted to the Health Management Center of Henan Hongli Hospital from October 2020 to October 2022 were selected as the CHD group, including 89 males and 56 females, aged(68.56±3.97)years old, ranging from 60 to 77 years old.According to the 1∶1 principle, another 145 health examination people in the department of Health Management Center of Henan Hongli Hospital during the same period were selected as the health examination group.All the subjects underwent ultrasonic electrocardiography, blood examination and coronary angiography.The levels of serum S100A12, FOXF1 and GLP-1 in patients with different lesion degree and number of lesion were compared between the two groups and CHD group, and the correlation with Gensini score and number of lesion was analyzed.Results:Serum S100A12 level in CHD group[(273.51±85.24)ng/L] was higher than that in health examination group[(203.67±72.04)ng/L], the levels of serum FOXF1(0.94±0.31)and GLP-1[(12.87±0.16)pmol/L]were lower than those of control group[(2.46±0.63)and(19.42±0.19)pmol/L], and the differences were statistically significant( P<0.05). The levels of serum S100A12 in patients with different disease degree in CHD group were compared, mild diseasemoderate disease>severe disease, the level of serum S100A12 in patients with different number of lesions was compared, single branch lesiondouble branch lesion>triple branch lesion, and the differences were statistically significant( P<0.05). In CHD group, serum S100A12 level was positively correlated with Gensini score and lesion number( P<0.001), while serum FOXF1 and GLP-1 level were negatively correlated with Gensini score and lesion number( P<0.001). Conclusions:Serum levels of S100A12, FOXF1 and GLP-1 are closely related to the severity of CHD in elderly patients, which can provide a reliable reference for clinical evaluation.
Objective:To explore the value of nutrition-related blood markers and nutrition risk in the diagnosis of frailty.Methods:This study was a cross-sectional study, a total of 214 elderly patients were selected from the department of Traditional Chinese Medicine in the Second Hospital of Tianjin Medical University from May 2022 to November 2022, including 113 males and 101 females, aged (75.50±9.54) years old, ranging form 60 to 101 years old.Baseline data (age, comorbidity and body mass index), nutritional risk [nutrition risk screening 2002 (NRS 2002)], and blood markers [hemoglobin, absolute lymphocyte (Ly), albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, uric acid, cholesterol and c-reactive protein (CRP)] were analyzed in both frail and non-frail patients.Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to evaluate the diagnostic and predictive value of blood markers and nutritional risk for frailty.Results:Of the 214 patients, frailty patients were 146, without frailty patients were 68, low hemoglobin patients were 148, low Ly patients were 90, low albumin patients were 150, low ALT patients were 22, low AST patients were 30, low creatinine patients were 39, low uric acid patients were 38, low cholesterol patients were 41 and high CRP patients were 120.The age [(77.14±0.83) years old], comorbidity (12.47±0.41), NRS 2002 score[(3.65±0.10)scores], FRAIL score[(4.05±0.09)scores] and CRP levels[(7.73±0.63)mg/dl] of frail patients were higher than those of non-frail patients[(72.00±0.87)years old、(9.47±0.52)、(1.76±0.17)scores、(0.04±0.04)scores、(4.95±1.08)mg/dl], body mass index[(21.67±0.34)kg/m 2], hemoglobin[(102.11±1.95)g/L], albumin[(32.56±0.49)g/L], ALT[(13.45±0.70)U/L], creatinine[(58.10±1.93)μmol/L], uric acid[(211.8±10.01)μmol/L], cholesterol levels[(3.65±0.11)mmol/L] were lower than those in non-frail patients[(24.72±0.39)kg/m 2, (134.59±15.30)g/L, (40.70±0.74)g/L, (19.85±2.15)U/L, (71.61±4.37)μmol/L, (267.91±9.78)μmol/L, (4.67±0.54)mmol/L], the differences were statistically significant ( P<0.05). Low hemoglobin (≤116.00 g/L), low albumin(≤36.30 g/L), low cholesterol (≤3.80 mmol/L), high CRP (≥2.18 mg/dl) and NRS 2002 scores(≥3.50 scores) are of diagnostic value for asthenia. Conclusions:NRS 2002, hemoglobin, albumin, cholesterol and CRP were valuable in the diagnosis of asthenia.
Objective:To analyze the clinical features of children with emergency facial trauma.Methods:This study was a case-control study.Clinical data of 679 children with facial trauma admitted to the emergency department of Burns and Plastic Surgery in the Northern Theater General Hospital from January 2021 to December 2022 were selected.Gender, age, time of injury, time to seek medical attention after injury, cause of injury, wound location, wound length, wound depth, operation, postoperative anti-scar measures, incidence of postoperative complications, postoperative scars and pain were analyzed.Results:There were 385 males and 294 females, the male to female ratio was about 1.3∶1, among which the 3 years old children accounted for the largest proportion.The occurrence time of facial trauma in children was mainly concentrated between 8: 00 and 22: 00.A total of 98.3% of children with facial trauma were treated within 6 hours after injury.The main cause of facial trauma in children was collision.The depth of the wound was (0.94±0.31) cm, and the length of the wound was (3.44±0.85) cm.The 6 to 9 years old group children and the 10 to 14 years old group children had less operation time, less intraoperative blood loss, less wound healing time, less postoperative complications and good clinical treatment.Most children were treated with combination therapy for anti-scar treatment.The vancouver scar scale(VSS) score [(6.28±1.28) points] and visual analogue scale (VAS) score [(2.97±0.42) points] at 3 months after surgery were lower than those [(8.36±1.52) points and (3.25±0.31) points] at 1 month after surgery, and the differences were statistically significant ( P<0.05). Conclusions:Children′s facial trauma has a specific incidence rule, and targeted preventive measures can reduce its occurrence.After facial trauma, children should go to the plastic surgery department in time for treatment through plastic and aesthetic technology, combined with a variety of anti-scar treatment measures, to minimize the possibility of postoperative scar occurrence.
目的:分析帆状胎盘产妇的临床资料及超声误诊漏诊原因。方法:本研究为回顾性病例分析研究，选取2019年1月至2021年12月在北京市延庆区医院(北京大学第三医院延庆医院)超声科接受中晚孕超声检查且产后经临床确诊为帆状胎盘的44例产妇作为研究对象，年龄(31.0±4.3)岁，年龄范围为25~42岁。分析产妇的临床资料、声像图特点。结果:超声诊断30例，符合率为68.2%(30/44)，漏诊8例，漏诊率为18.2%(8/44)，误诊6例，误诊率为13.6%(6/44)。44例帆状胎盘中有2例合并前置血管，均检出，均为动脉前置。结论:在中晚孕超声检查中，要重视帆状胎盘的检出，避免因误诊漏诊导致不良妊娠结局。
