Objective To analyze the effect of butylphthalide combined with edaravone and right camphor on patients with ischemic cerebrovascular disease.Methods From January 2021 to January 2022,a total of 100 patients with ischemic cerebrovascular disease admitted to the hospital were selected as the study objects, which were divided into control group and observation group, with 50 patients in each group.The control group was treated with edaravone and right camphor, and the observation group was treated with butylphthalide on the basis of the control group.The neural function, oxidative stress indicators, vascular endothelial function and neural markers, cerebrovascular blood flow, effective rate and adverse reactions of the two groups were compared.Results After treatment, the neurological function score of the observation group was lower than that of the control group（P＜0.05）;After treatment, the oxidative stress index in the observation group was lower than that in the control group（P＜0.05）;After treatment, VEGF and FMD in the observation group were higher than those in the control group, while NSE and PTX3 were lower than those in the control group（P＜0.05）;The diameter and blood flow velocity of arteries in the observation group were higher than those in the control group, and the resistance index was lower than those in the control group（P＜0.05）;The effective rate of the observation group was 98.00%,which was higher than that of the control group（84.00%,P＜0.05）;The incidence of adverse reactions was compared between the two groups（P＞0.05）.Conclusion Butylphthalide combined with edaravone and right camphor can effectively improve the neurological function and cerebrovascular blood flow in patients with ischemic cerebrovascular disease, with high safety.
Objective To observe the effect of deep muscle relaxation on pain after modified radical mastectomy for breast cancer.Methods A total of 80 female patients treated with radical mastectomy for breast cancer from October 2021 to December 2022 were chosen in the Affiliated Hospital of Weifang Medical University and randomly divided them into two groups.The operation was done under deep muscle relaxation（post-tetanic count stimulation, PTC≤2） in the observation group, while the operation was done under superficial muscle relaxation（train of four stimulation, TOF=4） in the control group.Visual Analogue Scale（VAS） was used to score the degree of pain and to test the serum levels of IL-6 and BK before and after the surgery.Results The postoperative VAS score in the observation group was lower than that in the control group（P＜0.05）.The postoperative IL-6 and BK levels in the observation group were lower than those in the control group（P＜0.05）.Conclusion Deep muscle relaxation which is used in the modified radical mastectomy for breast cancer has better anesthetic effect and it can significantly reduce the postoperative pain for the patients.
Objective To investigate the effect of external diaphragm pacing combined with respiratory training on respiratory muscle groups in patients with stroke recovery period.Methods Forty patients with respiratory dysfunction during stroke recovery period who met the inclusion criteria were randomly divided into respiratory training group（n=20） and the combined treatment group（n=20）,both groups received conventional rehabilitation therapy, the respiratory training group was given respiratory training treatment on the basis of this, and the combined training group was given extracorporeal diaphragm lift on the basis of the respiratory training group.After 6 weeks of treatment, the indicators such as diaphragm displacement, diaphragm and abdominal muscle thickness change rate, and the differences between the two groups of patients before and after treatment were measured and compared.Results After 6 weeks of treatment, the displacement of diaphragm in both groups increased compared with before treatment, and the change rate of diaphragm thickness and abdominal muscle thickness also increased compared with before treatment.Comparing the two groups, the difference of diaphragm displacement, diaphragm thickness change rate, abdominal muscle thickness change rate before and after treatment in the combined treatment group was larger than those in the respiratory training group（P＜0.05）.Conclusion For patients with respiratory dysfunction in the convalescent period of stroke, the external diaphragm pacing combined with respiratory training is better than the respiratory training treatment.Therefore, the external diaphragm pacing combined with respiratory training can promote the breathing of patients faster and better.Recovery of muscle strength, improvement of lung function, and enhancement of core muscle strength.
Objective To explore the risk factors of air pollutants and bronchial asthma and their effects on the acute attack of adult asthma, analyze the correlation between the concentration of inhalable particles in the air and asthma, and evaluate the preventive and therapeutic effects of health management programs on asthma.Methods A total of 218 asthma patients with acute attack were selected from the affiliated hospital of Weifang Medical University.Of the 218 patients, 112 were outpatients and 106 were hospitalized patients.The air quality was monitored as the air quality index（AQI）,inhalable particulate matter(PM 10 ),fine particulate matter(PM 2.5 ),sulfur dioxide（SO 2 ）,nitrogen dioxide（NO 2 ）,nitrogen oxides（NOx）,nitric oxide（NO）,carbon monoxide（CO） and ozone（O 3 ） in the same year.The risk factors of asthma were analyzed by Pearson correlation analysis and Logistic regression analysis.All patients with acute asthma were treated with pulmicort dubao plus oxdubao inhalation.In remission stage, all asthma patients were randomly divided into two groups, 102 cases in the experimental group and 95 cases in the control group.They were assessed by bronchial asthma control test score and monitored by peak current meter at home.Results Pearson correlation analysis shows that the acute attack of asthma is related to the concentrations of PM 10 ,PM 2.5 ,NO 2 ,SO 2 and CO in the air, with a strong correlation with PM 2.5 and a weak relationship with NO 2 .Stepwise regression analysis showed that PM 2.5 was the main cause of acute asthma attack.Univariate Logistic regression analysis showed that family history of asthma, allergic rhinitis, increased body mass index, asthmatic bronchitis in childhood and smoking were the main factors.Establish health management files, improve follow-up visits and regular follow-up for discharged patients.The ACT score of asthma control in remission observation group was higher than that in control group, and the number of attacks and hospitalizations was less than that in control group.After 6 months of lung function test, compared with before treatment, the forced expiratory pressure in one second increased, and the estimated PEF value increased by %,which had statistical significance.Conclusion The acute attack of asthma is related to the concentration of PM 10 ,PM 2.5 ,NO 2 ,SO 2 and CO in the air, and PM 2.5 is the main influencing factor for the acute attack of asthma.Acute asthma attack is related to family history of asthma, allergic rhinitis, increased body mass index, asthmatic bronchitis in childhood, smoking, etc.
Objective To investigate the clinical effect of Herbert screw through olecranon osteotomy in the treatment of coronal plane fracture of distal humerus.Methods Eight cases of coronal fracture of distal humerus were treated with Herbert screw through olecranon osteotomy approach.All fractures were classified as type Ⅳ according to Bryany-Morrey classification of humerus small head fracture.Among them two cases were classified as type ⅡA,five cases were classified as type ⅢA,and one case was classified as type ⅢB according to Dubberley classification.Results After 8 to 20 months of follow-up, all fractures healed well.The modified Cassebaum score was excellent in six cases and good in two cases.Conclusion The olecranon osteotomy approach is a good surgical approach for the treatment of the coronal plane fracture of the distal humerus, and Herbert screws can be used to firmly fix the fracture.
