Inflammation is generally considered as a pathological process, and the occurrence of multi-organ inflammatory diseases is usually accompanied by an inflammatory response. Persistent inflammation can eventually lead to organ dysfunction. In recent years, the study of mesenchymal stem cell-derived exosomes has found its unique anti-inflammatory effect, which provides a new idea for the treatment of multi-organ inflammatory diseases. This article reviews the effect of mesenchymal stem cell exosomes on multi-organ inflammatory diseases.
皮肤移植是烧创伤、慢性创面修复的主要方法,特别在大面积烧伤创面治疗中,植皮扩展比例、供区愈合时间、供受区瘢痕形成及手术疼痛等瓶颈问题亟待解决.本文综述微针技术的应用现状及皮肤移植技术的新进展,并介绍一种硅基微针负压提取法进行自体表皮移植的研究现状.
Objective:To detect the oncological and functional result of segmental reconstruction for the diaphyseal defect after the femur tumor resection under navigation.Methods:Between September 2008 and May 2017, 28 patients with bone sarcomas underwent surgical resection and diaphyseal segmental reconstruction under computer-assisted navigation in Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Capital Medical University. The cohort comprised 18 males and ten females with a median age of 20 years (range: 8-60 years). The tumors were osteosarcoma (n=20), chondrosarcoma (n=4), Ewing sarcoma (n=2), undifferentiated pleomorphic sarcoma (n=1), spindle cell sarcoma (n=1). This study made a pre-operative plan for each patient using navigation system software and performed navigation-aided resection. The reconstruction included custom-made prosthesis (n=22) and allograft (n=6). The average reconstruction length was 181 mm (85-275 mm). The average follow-up was 86.5 months (6-166 months). The oncological and functional results were detected.Results:Of the 28 patients, 22 remain disease free, one is alive with disease, and five died of the disease. The 5-years survival rate was 80.8%. Six patients developed lung metastasis. Three patients developed local recurrence and the LR rate was 10.7%(3/28). The custom-made prosthesis fracture occurred in 1 patient and the revision for distal femur tumor prosthesis performed. In another patient the prosthesis failed mechanically and revision needed. Two allograft fractures and one deep infection occurred in the allograft reconstruction group. The distal femur tumor prosthesis reconstruction in one fracture patient, plate removal and intramedullary fixation in another patient and debridement performed for deep infection patient. The mean Musculoskeletal Tumor Society score at the final follow-up was 91%(80%-100%). The 5-year survival rates for prosthesis and allograft were 92.3% and 75%, respectively.Conclusion:The oncological results are good for the resection of femur sarcoma under computer-assisted navigation. The MSTS function are good for both custom-made prosthesis and allograft reconstruction although the complication occurred. The salvage for the failure of reconstruction is conventional tumor implant reconstruction.
The skin stretching device designed based on skin stretching technique has been widely used in clinical practice due to its simple operation and better wound healing effect compared with the traditional treatment method. This paper reviews the theoretical basis, the advantages and disadvantages of common clinical stretching device, the precautions and contraindications of clinical application, and discusses the future development direction of skin stretching device.
Blunt aortic injury is a potentially fatal vascular trauma. However, due to its non-specific clinical manifestations and common combination with other traumas, it is difficult to be diagnosed and treated in time in many cases. Computed tomography angiography (CTA) has become the first choice for the diagnosis of blunt aortic injury. The grade of arterial injury based on CTA is an important determinant for perioperative mortality, as well as the indication of treatment. According to the severity of arterial injury, patients may receive conservative or surgical treatment. As long as the anatomical and clinical conditions permit, the mainstream operation is endovascular repair. Endovascular repair has a significant advantage over open surgery in reducing perioperative complications and death. This article reviewed the research progress of diagnosis, classification and treatment of blunt aortic injury, aiming to provide reference for clinical diagnosis and treatment of blunt aortic injury.
