Introduction: Atypical glandular cells (AGC) are rare but clinically significant due to their association with cervical and endometrial lesions. Although human papillomavirus (HPV) is the main etiological agent of cervical lesions, not all AGC are HPV-related, particularly those of endometrial origin. Given the heterogeneity of associated findings, their characterization is essential to guide clinical management. Objective: To describe the distribution of AGC subcategories and evaluate subsequent diagnostic findings, comparing findings between AGC (not otherwise specified) NOS and AGC (favor neoplastic) FN in women evaluated at a Brazilian university hospital. Methods: This is an observational, retrospective, analytical study with a retrospective cohort design, based on the review of cytology reports with an AGC diagnosis and their subsequent diagnostic investigation. Associations between categorical variables were assessed using Fisher’s exact test, with a significance level of 5%. Results: Among 22,246 cytology samples, 161 showed AGC (0.72%). After exclusions, 126 cases were included: 85.7% AGC-NOS and 14.3% AGC-FN. Neoplasia at any site was identified in 22.2% of women and was more frequent in AGC-FN (55.6%) than in AGC-NOS (16.7%) (p=0.001). A statistically significant difference was observed in the distribution of cervical findings between groups (p=0.003), with a higher proportion of neoplastic lesions in AGC-FN. No significant difference was found for endometrial findings (p=0.400). Endocervical cytology was performed in 68 women, showing a significant association between the initial AGC classification and subsequent cytological findings (p=0.003), although 44.4% of AGC-FN cases had negative results. Conclusion: AGC represents a heterogeneous clinical entity, with a higher frequency of neoplastic findings in AGC-FN compared to AGC-NOS, particularly in the cervix. These findings reinforce the importance of a comprehensive diagnostic investigation, particularly in cases classified as AGC-FN. In settings without access to HPV molecular testing, clinical, colposcopic, and histopathological evaluation remains essential.
Introdução: Células glandulares atípicas (AGC) são raras, porém clinicamente relevantes em razão de sua associação com lesões cervicais e endometriais. Embora o papilomavírus humano seja o principal agente etiológico das lesões cervicais, nem todas as AGC estão relacionadas à infecção viral, como nas atipias de origem endometrial. Diante da heterogeneidade dos achados associados, sua caracterização é essencial para orientar o manejo clínico. Objetivo: Descrever a distribuição das subcategorias de AGC e avaliar os resultados da investigação diagnóstica subsequente, comparando os achados entre AGC (sem outras especificações) SOE e AGC (favorecendo neoplasia) FN em mulheres atendidas em um hospital universitário brasileiro. Métodos: Trata-se de estudo observacional, retrospectivo, analítico, com delineamento de coorte retrospectiva, baseado na análise documental de citologias com diagnóstico de AGC e sua investigação diagnóstica subsequente. As associações entre variáveis categóricas foram avaliadas pelo teste exato de Fisher, adotando-se um nível de significância de 5%. Resultados: Entre 22.246 citologias, 161 apresentaram AGC (0,72%). Após exclusões, 126 casos compuseram a amostra: 85,7% AGC-SOE e 14,3% AGC-FN. Neoplasia em qualquer sítio foi identificada em 22,2% das mulheres, sendo mais frequente em AGC-FN (55,6%) do que em AGC-SOE (16,7%) (p=0,001). Houve diferença estatisticamente significativa na distribuição dos achados cervicais entre os grupos (p=0,003), com maior proporção de lesões neoplásicas em AGC-FN. Para o endométrio, não houve diferença significativa (p=0,400). A citologia endocervical foi realizada em 68 mulheres, com associação significativa entre a categoria inicial de AGC e os achados subsequentes (p=0,003), embora 44,4% das pacientes com AGC-FN tenham apresentado resultado negativo. Conclusão: AGC constitui uma entidade clínica heterogênea, com maior frequência de achados neoplásicos na subcategoria AGC-FN em comparação ao AGC-SOE, especialmente no colo uterino. Esses achados reforçam a importância da investigação diagnóstica abrangente, particularmente nos casos classificados como AGC-FN. Em contextos sem acesso ao teste molecular para papilomavírus humano, a avaliação clínica, colposcópica e histopatológica permanece essencial.
Kegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk meningkatkan produktivitas dan kemandirian peternak ikan air tawar di Desa Mariendal II melalui penerapan sistem feeder dan monitoring pakan ikan berbasis Internet of Things (IoT). Permasalahan utama mitra meliputi pemberian pakan yang masih dilakukan secara manual, ketidakteraturan jadwal pakan, pemborosan pakan, serta keterbatasan literasi teknologi. Metode pelaksanaan kegiatan menggunakan pendekatan partisipatif yang meliputi tahap persiapan, pelatihan dan implementasi sistem IoT, pendampingan, serta evaluasi. Evaluasi dilakukan menggunakan pre-test dan post-test untuk mengukur peningkatan pemahaman dan keterampilan peserta. Hasil kegiatan menunjukkan peningkatan rata-rata kompetensi peserta sebesar 47%, dengan peningkatan tertinggi pada keterampilan instalasi dan pengoperasian perangkat serta kemampuan membaca hasil monitoring pakan. Nilai effect size yang sangat besar menunjukkan bahwa peningkatan kompetensi dipengaruhi secara signifikan oleh intervensi kegiatan. Selain itu, penerapan sistem feeder otomatis memberikan dampak operasional berupa peningkatan keteraturan pemberian pakan, pengurangan pemborosan pakan, serta efisiensi waktu dan tenaga kerja peternak. Tingginya tingkat keberterimaan teknologi tercermin dari konsistensi penggunaan sistem oleh sebagian besar peserta setelah kegiatan berakhir. Dengan demikian, kegiatan PkM ini membuktikan bahwa penerapan teknologi IoT yang tepat guna dan disertai pendampingan berkelanjutan mampu meningkatkan efisiensi budidaya ikan sekaligus mendorong kemandirian peternak secara berkelanjutan.
Sistem Informasi Manajemen Rumah Sakit (SIMRS) memiliki peran strategis dalam mendukung pelayanan kesehatan, pengelolaan data pasien, serta proses administrasi rumah sakit. Tingginya ketergantungan terhadap SIMRS menuntut ketersediaan sistem yang andal dan beroperasi secara berkelanjutan. Namun, permasalahan downtime server masih sering terjadi dan berdampak langsung terhadap kualitas pelayanan. Kegiatan Pengabdian kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan kapasitas sumber daya manusia (SDM) teknologi informasi melalui pelatihan penanganan dan pencegahan downtime server SIMRS di RSU Mitra Medika. Metode pelaksanaan meliputi observasi lapangan, wawancara, diskusi kelompok terarah, analisis log server, pelatihan teknis, serta pendampingan penerapan prosedur operasional standar. Hasil kegiatan menunjukkan peningkatan pemahaman dan keterampilan peserta, penurunan frekuensi downtime sebesar 62,5%, serta pengurangan durasi downtime sekitar 60%. Selain itu, tingkat kepuasan pengguna terhadap stabilitas SIMRS meningkat secara signifikan. Kegiatan ini membuktikan bahwa pendekatan pelatihan dan pendampingan teknis yang kolaboratif efektif dalam meningkatkan keandalan SIMRS dan mendukung peningkatan kualitas layanan kesehatan.
Introduction: Brazilian public health faces constant challenges to meet demographic and social changes, and despite current policies, rates of sexually transmitted infections, such as syphilis, especially in pregnant women and newborns, are still high. Primary Health Care is recognized as the best way to act on maternal and child health, with prenatal care being essential for the diagnosis and follow-up of pregnant women. Objective: To analyze the social and epidemiological profile of pregnant women and newborns with syphilis in the Southeast region of Brazil between 2019 and 2022. Methods: This is a descriptive and cross-sectional research, with data from Brazilian Epidemiological Indicators and the 2023 Epidemiological Bulletin of the Brazilian Ministry of Health. Results: According to the results, the Southeast region concentrates almost 50% of the cases of gestational and congenital syphilis in Brazil. Although many pregnant women receive prenatal care and are diagnosed in the first trimester, a significant proportion still receive incomplete treatment, which negatively affects the newborn. Conclusion: Syphilis continues to be a serious public health issue, especially in the Southeast, with alarming growth rates. Therefore, it is essential to implement public policies that improve the quality of prenatal care, ensuring continuous follow-up during pregnancy and in the postpartum period for effective diagnosis and treatment of syphilis.
Pembangunan desa merupakan agenda prioritas nasional sebagaimana diamanatkan dalam Undang-Undang Nomor 6 Tahun 2014 tentang Desa yang menekankan kemandirian ekonomi, pemberdayaan masyarakat, serta penguatan kapasitas lokal. Desa Tanjung Pasir memiliki potensi sumber daya alam dan manusia yang dapat dikembangkan, namun masih menghadapi permasalahan berupa rendahnya inovasi produk lokal, keterbatasan pemanfaatan teknologi, serta perlunya peningkatan partisipasi dan kesadaran hukum masyarakat. Oleh karena itu, kegiatan Kuliah Kerja Nyata (PKM) dilaksanakan sebagai bentuk Pengabdian kepada Masyarakat untuk mendukung pembangunan desa melalui pendekatan ekonomi kreatif, teknologi, dan kebersamaan sosial. Realisasi kegiatan PKM dilaksanakan pada 31 Juli hingga 31 Agustus 2025 melalui berbagai program, antara lain pembuatan photo booth peringatan Hari Ulang Tahun Republik Indonesia, pemasangan label produk UP2K PKK, budidaya tanaman hias dengan teknik kokedama dan akuaponik, pendampingan kegiatan UP2K dan HUT RI, sosialisasi teknologi dan hukum kepada siswa SMP Satu Atap, serta pelaksanaan kegiatan sosial dan keagamaan bersama masyarakat desa. Hasil kegiatan menunjukkan meningkatnya partisipasi masyarakat, penguatan identitas dan branding produk UMKM desa, bertambahnya pengetahuan masyarakat mengenai inovasi ekonomi kreatif berbasis lingkungan, serta meningkatnya literasi hukum dan teknologi generasi muda. Secara keseluruhan, kegiatan PKM ini berkontribusi positif dalam mendorong pembangunan Desa Tanjung Pasir yang partisipatif, inklusif, dan berkelanjutan melalui sinergi antara mahasiswa, masyarakat, dan pemerintah desa.
Introduction: Syphilis is a sexually transmitted infection of high public health relevance, with increasing incidence in Brazil. Although screening protocols exist for pregnant women, there are gaps in knowledge regarding non-pregnant women. Objective: To describe the sociodemographic and behavioral profile of non-pregnant women receiving care in health services in Pelotas, Rio Grande do Sul, and the factors associated with positivity in treponemal tests for syphilis. Methods: A cross-sectional study was conducted between August 2023 and December 2024 with non-pregnant women aged 15–70 years attending outpatient clinics and Primary Health Care Units affiliated with the Federal University of Pelotas. Sampling was non-probabilistic. Sociodemographic, behavioral, and syphilis-related knowledge data were collected using a standardized questionnaire and rapid treponemal tests. Descriptive analyses and chi-square tests were performed (p<0.05). Results: A total of 2,021 women were included (mean age: 32.6 years; standard deviation: 8.3 years). The prevalence of reactive treponemal tests was 3.2% (64/2,021). An educational gradient was observed, with higher prevalence among women with lower schooling levels (4.7% in incomplete primary education vs. 0.85% in higher education; p<0.05). Single women and those in relationships with multiple partners showed higher prevalence. No significant differences were observed across age groups. Conclusion: The high prevalence of syphilis among non-pregnant women, particularly those with lower educational attainment, reinforces the need for screening and prevention strategies beyond the prenatal context.
Introdução: Apesar dos avanços nas condições sanitárias e da introdução da vacina contra a hepatite A, surtos esporádicos ainda ocorrem em algumas regiões do Brasil. A análise dos indicadores epidemiológicos da hepatite A na Grande Florianópolis permitirá uma compreensão mais detalhada das características da doença na população local, possibilitando a identificação de grupos mais vulneráveis e subsidiando estratégias direcionadas de prevenção e controle. Objetivo: Analisar o perfil dos casos e os indicadores epidemiológicos da Hepatite A na Grande Florianópolis no período de 2023-2024. Métodos: Estudo descritivo que analisou casos confirmados de hepatite A na Grande Florianópolis em 2023 e 2024. O perfil foi examinado com base em frequências absolutas e relativas, acompanhadas do cálculo das taxas de incidência e da razão de sexos. Ainda, utilizaram-se os testes qui-quadrado de Pearson e exato de Fisher para examinar diferenças de proporções. Resultados: Foram registrados 305 casos de hepatite A. Observou-se maior frequência de notificações no sexo masculino (84,6%), na faixa etária de 20 a 39 anos (79,3%) e em pessoas mais escolarizadas (45,9% em pessoas com ensino superior completo ou incompleto). A incidência de hepatite A em Florianópolis foi de 35,0/100.000 habitantes em 2023. O sexo masculino apresentou maior proporção de provável fonte sexual (66,8%) em relação às mulheres (25,0%), enquanto mulheres foram mais afetadas por água ou alimento contaminado (75,0%) (p<0,001). A via sexual foi mais frequente em indivíduos com ensino superior (66,7%), enquanto a ingestão de água ou alimentos contaminados prevaleceu entre aqueles com ensino fundamental (28,6%) (p=0,017). Conclusão: A análise dos casos de hepatite A na Grande Florianópolis destacou diferenças importantes no perfil epidemiológico, com maior frequência de casos em homens jovens e escolarizados, além de associações distintas entre vias de transmissão e fatores sociodemográficos, evidenciando a necessidade de estratégias específicas de prevenção e controle.
Perkembangan teknologi digital menuntut aparatur kelurahan untuk melakukan modernisasi dalam sistem pelaporan guna meningkatkan efektivitas, ketepatan, dan akuntabilitas administrasi pelayanan publik. Di Kelurahan Paninggilan Utara, proses pelaporan petugas lapangan masih dilakukan secara manual melalui aplikasi pesan instan, sehingga menimbulkan ketidakteraturan dokumen, kesulitan penelusuran, serta rendahnya keseragaman format laporan. Permasalahan tersebut menjadi dasar dilaksanakannya kegiatan pengabdian masyarakat berupa pelatihan pemanfaatan Google Drive sebagai sarana pelaporan digital yang lebih terstruktur, mudah diakses, dan terintegrasi. Kegiatan pengabdian dilaksanakan secara luring pada 4 Oktober 2025 di Aula Kelurahan Paninggilan Utara dengan melibatkan dosen dan mahasiswa Universitas Nusa Mandiri sebagai tim pelaksana. Realisasi kegiatan meliputi penyampaian materi mengenai konsep penyimpanan berbasis cloud, demonstrasi penggunaan Google Drive, serta pendampingan praktik langsung terkait pembuatan folder bersama, pengunggahan dokumen, penyusunan laporan digital, dan berbagi tautan pelaporan. Hasil pelatihan menunjukkan bahwa seluruh peserta mampu mengikuti tahapan kegiatan dengan baik dan mengalami peningkatan kompetensi digital, yang terlihat dari rata-rata nilai kuesioner yang berada pada kategori “Baik–Sangat Baik”. Peserta juga menyatakan bahwa pelatihan ini relevan dan bermanfaat untuk mendukung proses pelaporan di lingkungan kelurahan. Secara keseluruhan, kegiatan pengabdian ini berhasil mencapai tujuan yang ditetapkan dan memberikan kontribusi nyata terhadap perbaikan sistem pelaporan kelurahan melalui penerapan teknologi berbasis cloud
This Editor's Letter, which some may interpret as a manifesto, is about the need to always recognize the progress made by public administrators. However, it is necessary, perhaps fundamental, to demand better public health actions for all population groups, continuously. Here, we discuss equality, equity, and effectiveness in access to HPV vaccination within the Brazilian Unified Health System (SUS). Here, we make demands regarding the updating of modern active pharmaceutical ingredients, the same ones used for populations in countries with a high Human Development Index (HDI). After all, Brazil will join this group of nations in 2026. Here, we recount history, memory, humanities, academic life trajectory, along with a tangle of extension activities and positions on public health policies. In this Letter, there are no restrictions on expressing concerns.
Queremos, aqui, inaugurar a nova editoria de arte, história, humanidades. E a sífilis entra perfeita como uma comissão de frente, que não precisa pedir passagem. E para isso, oferece de forma inédita, gratuitamente, um livro também inédito: Syphilis Sive Morbus Perpetua/Sífilis ou Mal Perpétuo, 2ª. edição, Revista e Ampliada. Considere, leitor, também, submeter ao BJSTD/JBDST a sua contribuição: poema, poesia, conto, comentário sobre um filme, sobre uma peça teatral... Evidentemente que expresse alguma conexão com as DST/IST/HIV/AIDS.
O artigo discute a relevância das datas institucionais para mobilização da população em geral para a eliminação da sífilis e da sífilis congênita, no Brasil e no mundo. A questão é apresentada na perspectiva do campo da memória social, a partir dos autores Jô Gondar e Pierre Nora, considerando a necessidade de um ritual de memória para se evitar o esquecimento e a invisibilidade que historicamente cercam a sífilis e as infecções sexualmente transmissíveis. Por fim, o artigo propõe uma mobilização para a criação de uma data mundial única, coordenada pela Organização Mundial da Saúde.
Introduction: Women living with HIV/AIDS (WLHA) are more vulnerable to human papillomavirus (HPV) infection, particularly by high-risk oncogenic subtypes, due to HIV-associated immunosuppression. Objective: To assess the prevalence and distribution profile of HPV subtypes in WLHA, correlating findings with CD4 levels and age group. Methods: A cross-sectional study was conducted with 184 WLHA receiving care at a public referral center in Juiz de Fora, Minas Gerais, from May 2021 to May 2022. Self-collected vaginal samples were analyzed by RT-PCR to detect HPV subtypes. Associations between HPV infection, CD4 counts, and age were assessed using the chi-square test (p<0.05). Results: HPV infection was detected in 72% of the participants. Oncogenic subtypes not included in the quadrivalent vaccine were identified in 49.3% of the infected individuals, with HPV 52 and 58 being the most prevalent. A higher frequency of infection was observed in women with CD4 counts <500 cells/mm³, although no statistical association was found between CD4 levels and specific viral types. There was no significant association between age and the prevalence of major subtypes. Conclusion: WLHA show a high prevalence of HPV, particularly high-risk subtypes not covered by the quadrivalent vaccine. The findings support expanding immunization with the nonavalent vaccine and strengthening cervical cancer screening and control strategies in this population.
Introdução: A sífilis é uma infecção sexualmente transmissível de alta relevância em saúde pública, com crescente incidência no Brasil. Embora haja protocolos de rastreamento em gestantes, há lacunas no conhecimento sobre mulheres não gestantes. Objetivo: Descrever o perfil sociodemográfico e comportamental de mulheres não gestantes atendidas em serviços de saúde de Pelotas, RS, e os fatores associados à positividade em testes treponêmicos para sífilis. Métodos: Foi realizado um estudo transversal entre agosto de 2023 e dezembro de 2024 com mulheres não gestantes (15–70 anos) atendidas em ambulatórios e Unidades Básicas de Saúde vinculadas à Universidade Federal de Pelotas. A amostragem foi não probabilística. Dados sociodemográficos, comportamentais e de conhecimento sobre sífilis foram coletados por meio de questionário padronizado e testes treponêmicos rápidos. Análises descritivas e teste do qui-quadrado foram realizados (p<0,05). Resultados: Foram incluídas 2.021 mulheres (média de idade: 32,6 anos; desvio padrão: 8,3 anos). A prevalência de testes treponêmicos reagentes foi de 3,2% (64/2.021). Houve gradiente educacional, com maior prevalência entre mulheres com menor escolaridade (4,7% no ensino fundamental incompleto vs. 0,85% no ensino superior; p<0,05). Mulheres solteiras e em relações com múltiplos parceiros apresentaram maior prevalência. Não houve diferença significativa entre as faixas etárias. Conclusão: A elevada prevalência de sífilis em mulheres não gestantes, especialmente entre as de menor escolaridade, reforça a necessidade de estratégias de rastreamento e prevenção para além do contexto pré-natal.
Introdução: A saúde pública brasileira enfrenta desafios constantes para atender às mudanças demográficas e sociais e, apesar das políticas atuais, as taxas de infecções sexualmente transmissíveis, como a sífilis, especialmente em gestantes e recém-nascidos, ainda são elevadas. A Atenção Primária à Saúde é reconhecida como a melhor forma de atuação em saúde materno-infantil, sendo o pré-natal essencial para o diagnóstico e acompanhamento de gestantes. Objetivo: Analisar o perfil socioeconômico de gestantes e recém-nascidos com sífilis na região Sudeste do Brasil entre 2019 e 2022. Métodos: Trata-se de uma pesquisa descritiva e transversal, com dados dos Indicadores Epidemiológicos Brasileiros e do Boletim Epidemiológico de 2023 do Ministério da Saúde. Resultados: De acordo com os resultados, a região Sudeste concentra quase 50% dos casos de sífilis gestacional e congênita no Brasil. Embora muitas gestantes recebam cuidados pré-natais e sejam diagnosticadas no primeiro trimestre, uma proporção significativa ainda recebe tratamento incompleto, o que afeta negativamente o recém-nascido. Conclusão: A sífilis continua sendo um grave problema de saúde pública, especialmente no Sudeste, com taxas de crescimento alarmantes. Portanto, é essencial implementar políticas públicas que melhorem a qualidade do pré-natal, garantindo acompanhamento contínuo durante a gravidez e no período pós-parto para diagnóstico e tratamento eficazes da sífilis.
Despite more than a century of investigation, syphilis vaccine development has long been hindered by the unusual outer membrane of Treponema pallidum subsp. pallidum (TPA) and the historical inability to propagate syphilis spirochetes in vitro. Early observations using the rabbit model established that protective, antibody-mediated immunity is achievable. The recent definition of the repertoire of TPA outer membrane proteins (OMPs) defined the universe of potential targets for protective antibodies and provided a critical foundation for the ongoing syphilis vaccine development. Built on a “learning from nature” approach, the mapping of antibody responses elicited during natural infection against OMPs allowed the identification and prioritization of extracellular loops (ECLs) as vaccine targets. Immunization of animals with protein scaffolds displaying these targets generates high titers of antibodies able to recognize surface-exposed regions of the spirochete. Recent advances in long-term in vitro cultivation and genetic manipulation of TPA have enabled the development of assays to directly evaluate the functional activity of ECL-specific antibodies in promoting opsonophagocytosis, growth inhibition, impairment of motility, and outer membrane disruption. Next-generation platforms are being explored to enhance immunogenicity, simplify production, and facilitate scalable translation of these immunogens toward clinical evaluation. In parallel, researchers are uncovering the sequence variability in OMPs across circulating TPA strains to understand how mutations can affect antibody recognition and global vaccine efficacy. Collectively, these advances position the field to leverage structural, immunological, and microbiological insights to counter the stealth pathogen and, ultimately, achieve an effective syphilis vaccine.
Kegiatan pengabdian masyarakat ini dilaksanakan di Desa Ujung Rambung, Kecamatan Pantai Cermin, Kabupaten Serdang Bedagai. Wilayah ini menghadapi permasalahan serius dalam pengelolaan limbah plastik dan keterbatasan teknologi tepat guna untuk pemberdayaan ekonomi masyarakat. Program ini bertujuan untuk mengembangkan inovasi mesin batako otomatis berbasis Internet of Things (IoT) dan optimalisasi produksi kompos sebagai solusi terpadu yang mendukung ekonomi sirkular desa. Metode pelaksanaan meliputi pelatihan manajemen organisasi, penerapan teknologi pengolahan limbah, serta pendampingan pemasaran digital. Hasil kegiatan menunjukkan peningkatan signifikan dalam manajemen kelompok, produksi kompos berkualitas, dan pemanfaatan limbah plastik menjadi batako ramah lingkungan. Selain itu, inovasi IoT memungkinkan pemantauan suhu dan tekanan produksi secara otomatis, meningkatkan efisiensi dan konsistensi mutu produk. Program ini berkontribusi terhadap peningkatan pendapatan masyarakat, pengurangan limbah, dan penciptaan lapangan kerja baru berbasis teknologi tepat guna.
Introduction: Cytomegalovirus (CMV) is a widely disseminated virus, capable of remaining latent and reactivating, with high global seroprevalence. In Brazil, seroprevalence exceeds 95%, with primary infections predominating in childhood. Objective: To describe the clinical profile at birth and outcome at 12 months of age of patients diagnosed with congenital cytomegalovirus infection in a reference pediatric hospital in Florianópolis from 2017 to 2022. Methods: This was a retrospective, observational and descriptive study with secondary data analysis. The research was approved by the Human Research Ethics Committee. Results: Of the 20 cases included in the study, 12 (60%) were female and all were white coloured. 14/17 (82.3%) of the cases were full-term births and 14/16 (87.5%) had a low birth weight for gestational age. Jaundice was identified in 7/13 (53.8%), microcephaly in 5/18 (27.7%), conjugated hyperbilirubinemia in 5/8 (62.5%) and intracranial calcifications in 9/20 (45%) records. 6/20 (30%) cases failed the neonatal hearing screening and 5/20 (25%) presented bilateral loss of brainstem auditory evoked potential. At 12 months of age, bilateral hearing loss and microcephaly were found in 5/8 (62.5%) and 7/13 (53.8%) cases respectively. Conclusion: Low birth weight for gestational age, jaundice and microcephaly were prevalent changes. Intracranial calcifications were the most common neuroimaging finding. Important late sequelae were present at 12 months of age.
