Preclinical drug development incorporates the activities that link to the discovery of drug in the laboratory to human clinical trials. Before the clinical trials, tests and treatments are assessed in the research of preclinical. Preclinical research is not done with the persons. Preclinical studies also designed to identify the lead candidate from many hits; to develop the best procedure for new drug scale-up; to select the best formulation; to determine the route, frequency, and duration of exposure; and support the intended clinical trial design ultimately. The specifics of each preclinical development package may vary, but all have few common features.
The most recently discovered coronavirus causes coronavirus disease COVID-19. The common symptoms of COVID-19 are fever, dry cough, and tiredness. Siddha medicines which mainly focusses on enhancing the host immunity could play a major role in viral diseases. As per Siddha classical wisdom, improving immunity with immune boosters is one of the key approaches for prevention of disease and maintenance of health. The treatment protocol was fixed such as all the patients admitted in the ward were given kabasura kudineer as base medicine. In addition, other siddha medicines were given based on the associated symptoms. If fever was present Linga chendooram with thirikaduku chooranam, Brahmanantha Birava mathirai twice a day was given additionally. If cough was present Thalisadi vadagam, Adathodai manapagu was given additionally until the symptoms subsides. If anosmia was present Herbal Smolder, vasantha kusumahara mathirai, thalisadi vadagam and adathoda manapagu twice a day, if loose motion was present sundai vatral was given additionally. The treatment protocol and diet pattern was planned such that it balances the three humours, combats the diseases, improves general immunity with specific actions on the respiratory tract and provides adequate nutrition. Apart from this the entire In Patient (IP) block was disinfected using herbal fumigation. Further, a novel herbal air cleanser pouch was also provided to all patients which is to be kept inside the mask which would precisely filter the inhaling air & ward off the airborne microorganisms. The results and observations are encouraging. The combined therapy and procedure seemed to be very effective in the management of COVID-19 disease
