ÖZET: Kişniş (Coriandrum sativum L.), Apiaceae familyasına ait bir bitki olup
Obesity is one of the serious health condition in the world and contributes to many chronic illnesses augmenting to high risk of death rate. With the purpose of obesity treatment, natural sources come to be significant to replace commercial drugs due to their harmful effect to the body. Therefore, a lot of studies were conducted on natural sources due to their potential as medicinal herbs. Aquilaria sp. plants are well known in traditional medicine as a sedative, analgesic and digestive. Even though there were no reports on applications of Aquilaria sp. towards obesity treatment, this plant has traditionally been used as laxative for weight reducing. In this study, the anti-lipase activity of an extract of barks and leaves from A. subintegra and A. malaccensis were investigated. The anti-lipase activity was measured by colorimetric assay on pancreatic lipase activity using porcine pancreatic lipase (PPL; triacylglycerol lipase, EC 3.1.1.3). The result indicated that among these two species of Aquilaria, A. malaccensis bark in dichloromethane crude showed high anti-lipase activity. Thus, these results suggest that Aquilaria sp. plant extracts might be of therapeutic interest with respect to the treatment.
Acne vulgaris is a common inflammatory skin condition, which has been reclassified as a chronic disease. The spectrum of topical acne treatments has expanded substantially in recent years and various topical medications including topical dapsone are available. Dapsone has special physicochemical properties that make its topical formulation challenging. The aim of this study was preparing a hydrogel- thickened microemulsion as a topical delivery system for dapsone. The microemulsions composed of dapsone (5%), isopropyl myristate, tween 80, diethylene glycol monoethyl ether, ethanol and water were prepared. The optimum microemulsion was modified with carbomer 940. Droplet size, pH, refractive index, conductivity, rheology of the optimized formulation, and skin permeation of dapsone through rat skin were evaluated. The optimized formulation significantly increased the skin permeation of dapsone in comparison to that of control gel. Although incorporation of menthol increased the particle size, the flux of microemulgel consisting of menthol (5%) was 2.51 times higher than that of the control. However, the skin absorption of the drug was less than 3%. Six month accelerated studies proved the physicochemical stability of microemulgels. The results of this research indicate that menthol based hydrogel- thickened microemulsion system could be a promising vehicle for topical delivery of dapsone.
Using rarmpril as a model active pharmaceutical ingredient, the focus of the present study was to fabricate low-cost controlled release tablets using combinations of biopolymer and semi-synthetic polymers. Cellulose derivatives are more viscous where biopolymers form gels more easily. Xanthan gum can't shape a solid gel, result in fragmentation of gel around the tablets so that depend upon high concentration. Therefore, a combination was used to formulate tablet by direct compression. This combination of polymer provides low cost product with higher potentiality. Ingredients as per formulations were mixed in small polybag through hand blending. Then tablets were compressed one by one tablet in a hydraulic press. Prepared tablets were evaluated for hardness, weight variation, content uniformity, friability, surface pH and in-vitro dissolution studies. ANOVA was used to analyze the differences between release data. Swelling index, mucoadhesive strength and in-vitro residence time was studied to show gastroretention of the tablets. Formulated products exhibit sufficient quality and strength to formulate as a mucoadhesive tablet. Significant differences were found in drug release among different formulations (p <0.05) in all cases. Among all of formulations, Fll, F12 and F13 containing different ratio of xanthan gum and guar gum showed promising mucoadhesive strength and in-vitro residence time.
