Objective To analyze the effect of butylphthalide combined with edaravone and right camphor on patients with ischemic cerebrovascular disease.Methods From January 2021 to January 2022,a total of 100 patients with ischemic cerebrovascular disease admitted to the hospital were selected as the study objects, which were divided into control group and observation group, with 50 patients in each group.The control group was treated with edaravone and right camphor, and the observation group was treated with butylphthalide on the basis of the control group.The neural function, oxidative stress indicators, vascular endothelial function and neural markers, cerebrovascular blood flow, effective rate and adverse reactions of the two groups were compared.Results After treatment, the neurological function score of the observation group was lower than that of the control group（P＜0.05）;After treatment, the oxidative stress index in the observation group was lower than that in the control group（P＜0.05）;After treatment, VEGF and FMD in the observation group were higher than those in the control group, while NSE and PTX3 were lower than those in the control group（P＜0.05）;The diameter and blood flow velocity of arteries in the observation group were higher than those in the control group, and the resistance index was lower than those in the control group（P＜0.05）;The effective rate of the observation group was 98.00%,which was higher than that of the control group（84.00%,P＜0.05）;The incidence of adverse reactions was compared between the two groups（P＞0.05）.Conclusion Butylphthalide combined with edaravone and right camphor can effectively improve the neurological function and cerebrovascular blood flow in patients with ischemic cerebrovascular disease, with high safety.
Objective To observe the effect of deep muscle relaxation on pain after modified radical mastectomy for breast cancer.Methods A total of 80 female patients treated with radical mastectomy for breast cancer from October 2021 to December 2022 were chosen in the Affiliated Hospital of Weifang Medical University and randomly divided them into two groups.The operation was done under deep muscle relaxation（post-tetanic count stimulation, PTC≤2） in the observation group, while the operation was done under superficial muscle relaxation（train of four stimulation, TOF=4） in the control group.Visual Analogue Scale（VAS） was used to score the degree of pain and to test the serum levels of IL-6 and BK before and after the surgery.Results The postoperative VAS score in the observation group was lower than that in the control group（P＜0.05）.The postoperative IL-6 and BK levels in the observation group were lower than those in the control group（P＜0.05）.Conclusion Deep muscle relaxation which is used in the modified radical mastectomy for breast cancer has better anesthetic effect and it can significantly reduce the postoperative pain for the patients.
Objective To investigate the effect of external diaphragm pacing combined with respiratory training on respiratory muscle groups in patients with stroke recovery period.Methods Forty patients with respiratory dysfunction during stroke recovery period who met the inclusion criteria were randomly divided into respiratory training group（n=20） and the combined treatment group（n=20）,both groups received conventional rehabilitation therapy, the respiratory training group was given respiratory training treatment on the basis of this, and the combined training group was given extracorporeal diaphragm lift on the basis of the respiratory training group.After 6 weeks of treatment, the indicators such as diaphragm displacement, diaphragm and abdominal muscle thickness change rate, and the differences between the two groups of patients before and after treatment were measured and compared.Results After 6 weeks of treatment, the displacement of diaphragm in both groups increased compared with before treatment, and the change rate of diaphragm thickness and abdominal muscle thickness also increased compared with before treatment.Comparing the two groups, the difference of diaphragm displacement, diaphragm thickness change rate, abdominal muscle thickness change rate before and after treatment in the combined treatment group was larger than those in the respiratory training group（P＜0.05）.Conclusion For patients with respiratory dysfunction in the convalescent period of stroke, the external diaphragm pacing combined with respiratory training is better than the respiratory training treatment.Therefore, the external diaphragm pacing combined with respiratory training can promote the breathing of patients faster and better.Recovery of muscle strength, improvement of lung function, and enhancement of core muscle strength.
Objective To explore the risk factors of air pollutants and bronchial asthma and their effects on the acute attack of adult asthma, analyze the correlation between the concentration of inhalable particles in the air and asthma, and evaluate the preventive and therapeutic effects of health management programs on asthma.Methods A total of 218 asthma patients with acute attack were selected from the affiliated hospital of Weifang Medical University.Of the 218 patients, 112 were outpatients and 106 were hospitalized patients.The air quality was monitored as the air quality index（AQI）,inhalable particulate matter(PM 10 ),fine particulate matter(PM 2.5 ),sulfur dioxide（SO 2 ）,nitrogen dioxide（NO 2 ）,nitrogen oxides（NOx）,nitric oxide（NO）,carbon monoxide（CO） and ozone（O 3 ） in the same year.The risk factors of asthma were analyzed by Pearson correlation analysis and Logistic regression analysis.All patients with acute asthma were treated with pulmicort dubao plus oxdubao inhalation.In remission stage, all asthma patients were randomly divided into two groups, 102 cases in the experimental group and 95 cases in the control group.They were assessed by bronchial asthma control test score and monitored by peak current meter at home.Results Pearson correlation analysis shows that the acute attack of asthma is related to the concentrations of PM 10 ,PM 2.5 ,NO 2 ,SO 2 and CO in the air, with a strong correlation with PM 2.5 and a weak relationship with NO 2 .Stepwise regression analysis showed that PM 2.5 was the main cause of acute asthma attack.Univariate Logistic regression analysis showed that family history of asthma, allergic rhinitis, increased body mass index, asthmatic bronchitis in childhood and smoking were the main factors.Establish health management files, improve follow-up visits and regular follow-up for discharged patients.The ACT score of asthma control in remission observation group was higher than that in control group, and the number of attacks and hospitalizations was less than that in control group.After 6 months of lung function test, compared with before treatment, the forced expiratory pressure in one second increased, and the estimated PEF value increased by %,which had statistical significance.Conclusion The acute attack of asthma is related to the concentration of PM 10 ,PM 2.5 ,NO 2 ,SO 2 and CO in the air, and PM 2.5 is the main influencing factor for the acute attack of asthma.Acute asthma attack is related to family history of asthma, allergic rhinitis, increased body mass index, asthmatic bronchitis in childhood, smoking, etc.
Objective To investigate the clinical effect of Herbert screw through olecranon osteotomy in the treatment of coronal plane fracture of distal humerus.Methods Eight cases of coronal fracture of distal humerus were treated with Herbert screw through olecranon osteotomy approach.All fractures were classified as type Ⅳ according to Bryany-Morrey classification of humerus small head fracture.Among them two cases were classified as type ⅡA,five cases were classified as type ⅢA,and one case was classified as type ⅢB according to Dubberley classification.Results After 8 to 20 months of follow-up, all fractures healed well.The modified Cassebaum score was excellent in six cases and good in two cases.Conclusion The olecranon osteotomy approach is a good surgical approach for the treatment of the coronal plane fracture of the distal humerus, and Herbert screws can be used to firmly fix the fracture.
Tutor is the first person responsible for the training of graduate student.The big determinant of cultivation of graduate students is graduate tutors’ ability to foster character and civic virtue.Thus, the construction of postgraduate tutor team plays a central role in the improvement of education quality.Aimed at the problems existing in the tutor team, effective measures that can be taken to establish a high-quality tutor team and the requirements for the tutor team building is introduced in this paper.
Objective To explore the value of shear wave elastography（SWE） in diagnosis of acute bacterial prostatitis（ABP）,to provide a new and reliable imaging technology for clinical diagnosis of ABP.Methods There were 29 patients which diagnosed ABP were enrolled as the prostatitis group, and 30 health examinees in the same period were randomly enrolled as the control group.All of them underwent SWE to detect the maximum, mean, and minimum elasticity modulus of the prostate.The maximum, minimum and mean elasticity modulus of the two groups were statistically analyzed and compared.Results The maximum, minimum and average values of Young’s modulus in the prostatitis group and the control group were（32.1±10.8）kPa,（17.6 ±5.9）kPa and（5.7±3.0）kPa, and（3.0±1.1）kPa,（17.4±5.2）kPa and（7.1±1.3）kPa, respectively.The differences were statistically significant.Conclusion ABP can improve the hardness of prostate tissue.The elastic modulus of prostate has certain clinical value in the diagnosis of acute prostatitis.
Objective To investigate the expression of PD-L1 in colorectal cancer and its clinicopathologic features.Methods From January 2018 to March 2022,a total of 193 patients with colorectal cancer underwent surgery in Weifang Traditional Chinese Medicine Hospital were enrolled in the study.The expression of PD-L1 protein was detected by immunohistochemistry.Results The positive rate of PD-L1 protein expression was 27.98%（54/193）.The expression of PD-L1 in colorectal cancer was significantly higher than that in para-cancerous tissues 3.11%（6/193）.PD-L1 was correlated with pathological classification（P=0.002）,TNM stage（P＜0.001）,tumor size（P=0.022） and lymph node metastasis（P＜0.001）.There was no significant difference among age（P=0.124）,sex（P=0.949） and parts（P=0.119）.The expression of PD-L1 in lymph node metastases was related to the differentiation（P=0.031）,but independent of the size（P=0.672）.Conclusion The expression of PD-L1 in colorectal cancer is higher than that in adjacent tissues.But the expression of PD-L1 in colorectal cancer is lower than that in other tumors.The expression of PD-L1 is closely related to the clinicopathological characteristics of colorectal cancer, and plays an important role in the diagnosis and treatment of colorectal cancer.
Objective To compare the effect of endoscopic tympanoplasty and microscopic tympanoplasty in patients with chronic otitis media（COM）.Methods From April 2020 to April 2022,a total of 102 patients with COM treated in the hospital were selected and divided into group A（n=51） and group B（n=51） according to the random number table method.Both groups were treated with tympanoplasty.Group B was performed under the assistance of microscope, and group A was performed under the assistance of ear endoscope.The surgical effects, surgical indicators, hearing indicators before and after surgery levels, and the incidence of complications were compared between the two groups.Results The excellent and good rate of group A was 98.04%（50/51）,superior to group B in which it was 84.31%（43/51,P＜0.05）.Compared with group B,group A had shorter dry ear time, operation time, tympanic membrane healing time, and less intraoperative blood loss（P＜0.05）;In comparison with group B,group A had lower average air conduction hearing threshold and average air-bone conduction difference at one and three months postoperatively（P＜0.05）;The sIL-2R and IL-8 of ear effusion on the first and third postoperative day in group A were lower than those in group B（P＜0.05）;The serum levels of AD,Cor and NE on the first and third postoperative day in group A were lower than those in group B（P＜0.05）.The total incidence of complications in group A was 1.96%（1/51）,which was lower than 15.69%（8/51） in group B（P＜0.05）.Conclusion Compared with tympanoplasty under microscope for COM patients, endoscopic tympanoplasty has more advantages in improving surgical results, optimizing surgical indicators, improving hearing level, reducing complications, and relieving inflammatory stress state.The stress response is less severe.
Objective To analyze the effect of core muscle group training compared with warm acupuncture and moxibustion on symptom improvement, lumbar function, lumbar mobility, pain degree of patients with lumbar disc herniation（LDH） in the recovery period after minimally invasive surgery.Methods A total of 94 cases of LDH convalescent patients treated by minimally invasive percutaneous foraminal surgery in the hospital from June 2018 to January 2021 were selected and divided into warm acupuncture and moxibustion group（n=47） and core muscle training group（n=47） according to different methods of rehabilitation treatment.The warm acupuncture and moxibustion group received warm acupuncture moxibustion rehabilitation treatment, and the core muscle training group conducted core muscle training on the basis of the warm acupuncture group rehabilitation treatment.The effect of rehabilitation treatment, the degree of symptom improvement, lumbar function, lumbar mobility, and the degree of pain were compared between the two groups.Results The total effective rate of rehabilitation treatment in the core muscle training group was higher than that in the warm acupuncture and moxibustion group（P＜0.05）;After one month of rehabilitation treatment, the scores of clinical symptoms such as low back pain, straight leg lifting test, gait and sensory disturbance in both groups were higher than before rehabilitation treatment（P＜0.05）;The scores of low back pain, straight leg lifting test, gait and sensory disturbance in core muscle group training group were higher than those in warm acupuncture and moxibustion group（P＜0.05）;After one month of rehabilitation treatment, the flexion and extension activities of the two groups were greater than before rehabilitation treatment（P＜0.05）;The flexion and extension activities of the core muscle training group were greater than those of warm acupuncture and moxibustion group（P＜0.05）;After one month of rehabilitation treatment, the scores of Oswestry dysfunction index（ODI） and VAS in both groups were lower than before rehabilitation treatment（P＜0.05）;The ODI score and VAS score in the core muscle training group were lower than those in the warm acupuncture and moxibustion group（P＜0.05）.Conclusion The core muscle group training combined with warm acupuncture and moxibustion can effectively improve the clinical symptoms of patients with LDH in the recovery period after minimally invasive surgery, improve the lumbar function and lumbar mobility, improve the pain level of patients, and contribute to the rapid recovery of lumbar function of patients.
Objective To investigate the three schemes in the treatment of intractable postpartum hemorrhage（IPH） due to uterine asthenia.Methods The clinical data of 150 patients with uterine asthenia IPH were retrospectively analyzed.According to the different treatment schemes, the patients were divided into groups A,B and C.Group A underwent intrauterine gauze packing and group B underwent modified B-Lynch suture, while group C underwent Modified B-Lynch suture combined with uterine gauze packing.The treatment, uterine contractility, sex hormone level and uterine hemodynamics of the three groups were compared.Results The Hemostasis time, length of hospital stay, duration of bloody lochia, amount of bleeding one day after operation in the group C were the least, those in group B were more than group C,while those in group A were the most in the three groups（P＜0.05）.Compared with group A,the end diastolic flow velocity（EDV）,systolic flow velocity（PSV）,estradiol（E 2 ） at six weeks after operation were significantly higher in group B and C.In comparison with group A,the nitric oxide（NO）,nitric oxide synthase（NOS）,resistance index（RI）,luteinizing hormone（LH） at six weeks after operation and follicle stimulating hormone（FSH） at six weeks after operation were significantly lower in group B and C（P＜0.05）.Compared with group B,EDV,PSV and E 2 at six weeks after operation were significantly higher in group C,and NO,NOS,RI,LH at six weeks after operation and FSH at six weeks after operation were significantly lower in group C（P＜0.05）.Conclusions Uterine gauze packing combined with Modified B-Lynch suture has the best effect in the treatment of uterine asthenia IPH,which can reduce the hemostasis time, hospital stay, duration of bloody lochia and the amount of bleeding one day after operation, and improve the uterine contractility, sex hormone level and uterine hemodynamics.The effects of modified B-Lynch suture are the second, and the effects of intrauterine gauze packing are the worst.
Objective To explore the effect of agatroban in combination on sphingosine 1-phosphate and MMP-8 levels in patients with acute cerebral infarction.Methods A total of 152 patients with acute cerebral infarction treated in the hospital from February 2021 to February 2022 were selected as the study subjects, which were divided into the combination group and the single-drug group with 76 patients in each group.The combination group was treated with agatroban plus alprostadil and the single drug group was treated with alprostadil treatment alone.The vascular endothelial function indicators, inflammatory indicators, sphingosine 1-phosphate, MMP-8 levels and adverse effects and clinical efficacy were compared between the single drug group and the combination group.Results The clinical efficacy in the combination group was better than that in the single-drug group（P＜0.05）;The adverse reaction rate in the combination group was slightly higher than that in the single-drug group（P＜0.05）;The levels of ET-1,TNF-ɑ,IL-6,hs-CRP and MMP-8 in the combination group were lower than those in the the single-drug group, while the levels of NO and 1-phosphate in the combination group were higher than those in the the single-drug group（P＜0.05）.Conclusion Agatroban combined with alprostadil treatment can improve the levels of 1-phosphate sphingosine and MMP-8 in patients with acute cerebral infarction and promote recovery with satisfied results.
Objective To retrospectively analyze the clinical data of laparoscopic surgery and traditional laparotomy in the treatment of low rectal cancer, and compare the advantages and disadvantages of laparoscopic surgery and traditional surgery in order to provide theoretical basis for the selection of treatment measures.Methods A total of 186 patients with low rectal cancer treated by surgery were selected as the study subjects, on the basis of different surgical treatment methods, which were divided into two groups, with 89 cases in the laparoscopy group and 97 cases in the traditional laparotomy group.The medical records of the two groups of subjects were collected, mainly including the operation time, intraoperative bleeding, hospital stay, postoperative exhaust time, incidence of anastomotic leakage and anastomotic bleeding, unplanned reoperation rate, left colon artery preservation rate, injury rate, recurrence and metastasis rate.Results The intraoperative bleeding volume, postoperative exhaust time, hospital stay and left colon artery retention rate in the laparoscopic group were lower than those in the traditional laparotomy group（P＜0.05）,and the operation time in the laparoscopic group was longer than that in the traditional laparotomy group（P＜0.05）.There was no statistical difference between the two groups in the incidence of anastomotic leakage or the incidence of bleeding and the rate of unplanned reoperation（P＞0.05）.There was no significant difference in complications and long-term follow-up（P＞0.05）.Conclusion Compared with traditional laparotomy, there is no significant difference in the postoperative complications and long-term effects of laparoscopic surgery, but laparoscopic surgery for low rectal cancer has less trauma and it is more conducive to postoperative recovery of patients, which is worthy of clinical promotion and application.
Objective To analyze the value of color Doppler echocardiography and left ventricular ejection fraction in the diagnosis of chronic heart failure.Methods From January 2017 to December 2019,a total of 96 patients with chronic heart failure admitted to the hospital were enrolled.The patients were divided into two groups according to left ventricular ejection fraction（LVEF）.Among them 47 patients with normal LVEF were taken as the reference group, and 49 patients with abnormal LVEF were taken as the observation group.All patients underwent cardiac color photo examination（1-5MHz probe frequency）,left ventricular end-diastolic diameter（LVEDD）,left ventricular end-systolic diameter（LVESD）,and LVEF were compared between the two groups before and after treatment.Results LVEDD and LVESD [（60.25±2.54）mm,（53.26±2.77）mm] in the observation group were significantly lower than those in the reference group [（65.26±3.26）mm,（56.82±3.33）mm],and LVEF（42.14±3.99）% in the observation group was significantly higher than that in the reference group（32.62±3.26）% with statistically significant differences（t=8.3754,5.6820,12.8255,P＜0.001）.After treatment, LVEDD and LVESD in the observation group were significantly lower than those before treatment [（59.26±2.62）mm,（52.26 ± 2.46） mm],and LVEF（43.57±2.95）% in the observation group was significantly higher than those before treatment（32.62±3.26）% with statistical significance（t=9.7130,7.7099,17.4339,P＜0.001）.There was no significant difference in LVEF,LVEDd, LVESD [（42.14±3.99）%,（60.25±2.54） mm,（53.26±2.77） mm] in the reference group before and after treatment[（43.01±3.82）%,（60.11±2.49） mm,（52.99±2.88） mm]（t=1.0798,0.2698,0.0632,P=0.2831,0.7879,0.6443）.Conclusion In the diagnosis of chronic heart failure with multiple causes, color Doppler echocardiography and LVEF can accurately evaluate the patient’s condition and treatment effect, and it is noninvasive and easy to operate, which is worth learning.
Objective To investigate the effect of minimally invasive locking plate internal fixation（MIPPO） in the treatment of proximal humeral fractures（PHFs）.Methods From June 2019 to March 2022,a total of seventy-four patients with PHFs admitted to the hospital were randomly divided into group A（n=37） and group B（n=37）.Group B received open reduction and internal fixation（ORIF） and group A received MIPPO.The operation indexes, visual analogue scale（VAS） score before and after operation, shoulder joint range of motion, callus growth, Constant-Murley shoulder joint function score, bone metabolism: osteoprotegerin（OPG）,receptor activator of nuclear factor-kappaB（RANK）,receptor activator of nuclear factor-kappaB ligand（RANKL） level and complication rate of two groups were compared.Results Compared with group B,group A had shorter fracture healing time, shorter hospitalization and operation time, and less intraoperative blood loss（P＜0.05）;Compared with group B,the VAS scores in group A were lower three and seven days after operation（P＜0.05）;The callus growth scores in group A were higher than that in group B one month and three months after operation（P＜0.05）;Group A had higher shoulder joint lift and abduction range of motion and Constant-Murley score one month and three months after operation, than those in group B（P＜0.05）;In comparison with group B,group A had higher serum OPG levels and lower serum RANK and RANKL levels one month and three months after operation（P＜0.05）;The total complication rate 2.70%（1/37） in group A was lower than 21.62%（8/37） in group B（P＜0.05）.Conclusion Compared with the treatment of PHFs, MIPPO treatment has more advantages in optimizing surgical indicators, reducing pain, improving shoulder joint function and mobility, promoting callus growth, reducing complications, which is more conducive to promoting fracture healing.
Objective To study the clinical efficacy of voglibose combined with insulin glargine in the treatment of elderly type 2 diabetes mellitus（T2DM）.Methods A total of 106 elderly patients with T2DM were selected and divided into control group and observation group according to different treatment schemes, with 53 cases in each group.Both groups were given routine intervention.The control group was treated with gliclazide combined with voglibose, and the observation group was treated with voglibose combined with insulin glargine.The curative effect, fasting blood glucose（FBG）,glycosylated hemoglobin（HbA1C）,2h postprandial blood glucose（2hPG）,and the incidence of hypoglycemia were compared between the two groups.Results The total effective rate in the observation group（96.23%） was higher than that in the control group（81.13%）（P＜0.05）;After treatment, FBG,HbA1C and 2hPG in the observation group were lower than those in the control group（P＜0.05）;The incidence of hypoglycemia in the observation group（3.77%） was lower than that in the control group（20.75%）（P＜0.05）.Conclusion Voglibose combined with insulin glargine has a significant effect in the treatment of elderly T2DM patients, which can promote the improvement of blood glucose levels.
Objective To observe the clinical effect of prone suspension reduction method combined with unilateral puncture kyphoplasty for Ⅰ,Ⅱ stage Kümmell disease.Methods From October 2020 to October 2021,a total of 50 patients with Kümmell disease who underwent surgical treatment were randomly selected and divided into observation group and control group according to different treatment methods, with 25 cases in each group.The observation group was treated by prone position suspension and reduction method combined with unilateral puncture kyphoplasty, while the control group was treated with unilateral puncture kyphoplasty.The visual analog scale（VAS） score, anterior wall height（VH）,and cobb angle were recorded.Results Compared with the preoperative results, VAS score decreased at 1 day, 12 weeks and 24 weeks, VH was significantly increased, and the cobb angle decreased, statistically significant（P＜0.05）;The VAS score of each observation node in the treatment group was lower than those in the control group（P＜0.05）.VH in the treatment group was higher than that in the control group（P＜0.05）.The cobb angle in the treatment group was lower than that in the control group（P＜0.05）. Conclusion Prone suspension reduction method combined with unilateral puncture kyphoplasty Ⅰ,Ⅱ Kümmell disease can improve the effect of pain symptoms, restore the vertebral height, improve kyphosis deformity, reduce trauma and other aspects.
铁死亡(ferroptosis)是一种铁依赖性的、调控细胞脂质过氧化物失衡引起的程序性死亡.不同于细胞凋亡、自噬和坏死等细胞死亡,铁死亡过程以谷胱甘肽(glutathione,GSH)耗尽、谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)失活和活性氧(reactive oxygen species,ROS)促进脂质过氧化等特征为主,最终引起细胞内脂质过氧化调节失衡.长链非编码RNA(long non-coding RNA,lncRNA)是一种长度超过200个核苷酸且不编码蛋白质的RNA.有研究表明,在实体肿瘤中,lncRNA可以调控铁死亡过程,引起肿瘤细胞增殖、侵袭和转移增加.例如,在肺癌和胃癌中,表达上调的lncRNA-NEAT1和BDNF-AS抑制铁死亡,促进肿瘤细胞增殖;在肺癌和肝癌中,下调的lncRNA-H19和PVT1促进铁死亡,抑制肿瘤细胞增殖.因此,本文将从铁死亡概览出发,综述相关长链非编码RNA在常见肿瘤中的最新研究进展,以期为肿瘤预后评估和靶向治疗提供理论依据.
Objective The present study aims to analyze the causes of air leakage of different types of laryngeal mask airway（LMA） during hysteroscopic day surgery under general anesthesia.Methods The study enrolled 120 American Society of Anesthesiologists（ASA） Ⅰ or Ⅱ patients, who were aged between 18 to 65 without any laryngeal mask anesthesia contraindications.Patients were randomly divided into three groups-classic laryngeal mask group（group C）,flexible laryngeal mask group（group F） and supreme laryngeal mask group（group S）.Different types of LMA were selected according to the weight of the patients.After routine anesthesia induction, LMA was inserted, and the position was examined by fiberoptic bronchoscopy to observe the incidence and causes of air leakage during the operation.Results All 120 patients were successfully implanted with LMA.One patient with air leakage in group F was excluded due to the small size of LMA.Finally, a total of 119 patients were included in the following analysis.There were seven cases of laryngeal mask air leakage, including two cases in group C,two cases in group F and three cases in group S,with no significant difference in the incidence of air leakage among the three groups（P＞0.05）.Additionally, all the seven patients had glottis closure during their laryngeal mask air leakage without any change in the position of the laryngeal mask.Conclusion There is no difference in the incidence of air leakage among different types of LMA during general anesthesia in gynecological hysteroscopic day surgery.The main cause of air leakage of LMA during the operation is related to the increase of airway pressure caused by glottis closure.
目的 对比腰椎转移瘤放疗中三维适形放疗（3D-CRT）、正向调强放疗（fIMRT）和静态调强放疗（sIMRT）三种治疗技术的剂量学特点及治疗效率，探讨适用于基层医院的腰椎转移瘤放疗方式。方法 回顾性选取29例腰椎转移瘤患者，处方剂量为40.5Gy/15f。采用雷泰治疗计划系统为每个病例重新设计3D-CRT、,fIMRT和sIMRT计划。对比分析3组放疗计划的靶区剂量参数、危及器官受量、机器跳数及治疗时间。结果 在3D-CRT、fIMRT、sIMRT计划中，适形度指数（CI）分别为0.73±0.05,0.82±0.05,0.75±0.05（P=0.000,0.000,0.028）;均匀度指数（HI）分别为0.181±0.048,0.101±0.015,0.099±0.020（P=0.000,0.587,0.000）;机器跳数分别为（375.3±30.9）MU,（397.4±22.7）MU,（687.0±80.0）MU（P=0.000）;单次治疗时间分别为（313.0±7.3）s,（391.8±23.3）s和（748.9±59.2）s（P=0.000）。靶区剂量D 2 与D mean 对比结果均为3D-CRT＞sIMRT＞fIMRT;D 98 对比结果sIMRT＞3D-CRT＞fIMRT;肾脏D mean 、与脊髓D max 对比结果均为3D-CRT＞sIMRT＞fIMRT;肾脏V 12 、肝脏D mean 、胃D mean 与小肠V 15 的对比结果均为3D-CRT＞fIMRT＞sIMRT。结论 fIMRT计划相比3D-CRT计划有着较大剂量学优势，且相对sIMRT计划机器跳数少，治疗时间短，降低了运动误差的影响，可为患者带来一定获益，该技术可作为腰椎转移瘤放疗的选择。
