Background andAim: Hypertension remains a major global health challenge affecting over 1.28 billion adults worldwide. Conventional hypertension management often involves multiple medications with adverse effects and economic burden, while natural alternatives such as ginger and garlic have demonstrated promising cardiovascular benefits. This randomized controlled trial evaluated and compared the antihypertensive effects of ginger and garlic supplementation, individually and in combination, among male hypertensive patients. Materials and methods: A total of 120 hypertensive male participants were randomly allocated to four groups (n = 30 each): control, ginger (2 g twice daily), garlic (2 g twice daily), and ginger + garlic (2 g each twice daily). Participants mixed crushed herbs with yogurt and consumed it for 90 days. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at baseline and after 90 days. Results: All intervention groups demonstrated statistically significant reductions in both SBP and DBP compared to controls (p < 0.05).The ginger group showed a mean SBP reduction from 180 +/- 1.40 to 130 +/- 1.26 mmHg and a DBP reduction from 130 +/- 2.35 to 90 +/- 2.45 mmHg. The garlic group exhibited similar results, with an SBP of 129 +/- 1.27 mmHg and a DBP of 89 +/- 2.48 mmHg. The combination group demonstrated the greatest reduction, with an SBP of 120 +/- 1.20 mmHg and a DBP of 85 +/- 0.27 mmHg. When comparing the ginger and garlic groups, no statistically significant difference was observed (p > 0.05), indicating comparable efficacy. Conclusions: Ginger and garlic supplementation effectively reduced blood pressure in hypertensive patients, with their combination showing enhanced benefits. These herbs may serve as cost-effective, well-tolerated adjuvant therapies in hypertension management, reducing dependence on multiple pharmacological agents and their associated adverse effects.
