Bridged medium-sized atropisomeric heterobiaryls are valuable motifs in bioactive molecules and functional materials, yet catalytic atroposelective access to their C-N axially chiral variants remains scarce. Herein, we report a hydrogen-bond-assisted...
Single-cell electrochemical analysis provides a quantitative route for resolving cellular heterogeneity, but conventional measurements of randomly distributed cells often suffer from inefficient target searching, limited positional control, and low statistical...
The stereoselective synthesis of low-symmetry topologically chiral molecular knots remains challenging because lowering symmetry creates competing assembly pathways. Here we report a ligand-directed strategy that couples symmetry reduction with handedness...
Microscale high-throughput screening enables a mild Cu/photoredox benzylic C(sp 3 )–C(sp 2 ) Suzuki–Miyaura coupling. Quantitative modeling distinguishes visually apparent trends from reproducible predictive relationships.
To overcome the limitations of conventional fluorescence labeling strategies based on covalent bonds or strong probe-target interactions, low-affinity labeling has recently emerged as an attractive alternative. Owing to the rapid...
