AIM To investigate the correlation between the expression levels of serum Krüppel-like transcription factor 8(KLF8)and glucose transporter 4(GLUT4)and the severity of coronary heart disease patients with impaired glucose regulation.METHODS A total of 204 patients with coronary heart disease admitted to our hospital from March 2021 to September 2022 were selected as the study subjects,according to whether the patients had impaired glucose regulation,they were divided into non-impaired glucose regulation group(94 cases)and impaired glucose regulation group(110 cases).According to the results of coronary angiography,patients with impaired glucose regulation were grouped into single vessel lesion group(39 cases),double vessel lesions group(42 cases)and triple vessel lesions group(29 cases).According to Gensini score,patients with impaired glucose regulation were divided into mild group(42 cases),moderate group(38 cases)and severe group(30 cases).The serum KLF8 mRNA level of the subjects was measured by real-time fluorescence quantitative PCR(qRT-PCR)and the expression level of GLUT4 in the subjects'serum was detected by enzyme-linked immunosorbent assay(ELISA).Pearson was applied to analyze the correlation between serum KLF8,GLUT4 levels and indicators.RESULTS Compared with the non impaired glucose regulation group,the impaired glucose regulation group significantly increased fasting blood glucose,2-hour postprandial blood glucose,triglycerides,low-density lipoprotein,and total cholesterol;The levels of serum KLF8 and GLUT4 in the impaired glucose regulation group decreased significantly;Compared with patients with impaired glucose regulation in single vessel coronary heart disease,the levels of serum KLF8 and GLUT4 in the two vessel coronary heart disease group and the three vessel coronary heart disease group were significantly lower;Compared with patients with impaired glucose regulation in coronary heart disease with dual vessel lesions,the levels of serum KLF8 and GLUT4 in the triple vessel lesion group were significantly lower;The levels of serum KLF8 and GLUT4 in patients with impaired glucose regulation in coronary heart disease decreased significantly with the severity of the disease;Pearson correlation analysis showed that serum KLF8 and GLUT4 levels in patients with impaired glucose regulation and coronary heart disease were negatively correlated with fasting blood glucose,2-hour postprandial blood glucose,triglycerides,low-density lipoprotein,total cholesterol levels,and Gensini scores.The above statistical differences were all(P<0.01).CONCLUSION The expression levels of serum KLF8 and GLUT in coronary heart disease patients with impaired glucose regulation are obviously decreased,which is negatively correlated with the severity of the disease.
AIM To investigate the influences of Jinkui Shenqi Pill combined with sacubitril-valsartan on TCM syndrome integral(TCMSI),mean ventricular wall stress(MWS)and serum myostatin(MSTN)levels in patients with chronic heart failure(CHF).METHODS A total of 100 CHF patients admitted in our hospital from March 2021 to April 2022 were selected as the research subjects and they were randomly grouped into the control group(50 cases)and the observation group(50 cases).The control group was treated with sacubitril-valsartan and theobservation group was treated with Jinkui Shenqi Pill and sacubitril-valsartan.TCMSI score,MWS and serum MSTN level were compared between the two groups.RESULTS The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);Compared with before treatment,the TCMSI scores of the two groups significantly decreased after treatment,and the observation group was significantly lower than the control group(both P<0.01);After treatment,the stroke volume(SV),left ventricular ejection fraction(LVEF),and 6-minute walking test(6MWT)distance values(LVEF and 6MWT)of the two groups significantly increased,and the observation group was significantly higher than the control group(all P<0.01);Compared with before treatment,the average wall stress(MWS)and left ventricular end systolic diameter(LVESD)were decreased,left ventricular end diastolic diameter(LVEDD)and left ventricular end diastolic volume(LVEDV)were increased,and left ventricular end systolic volume(LVESV)was significantly decreased in both groups after treatment,and the difference between observation group and control group was significant(all P<0.01);Compared with before treatment,after treatment,the standard deviation between sinus beats(SDNN),root mean square(RMSDD)of normal adjacent sinus beat interval difference,percentage of adjacent sinus beat interval difference>50 ms(PNN50),and high-frequency Hertz(HF)were significantly increased in both groups,and the observation group was significantly higher than the control group(all P<0.01);Compared with before treatment,the serum MSTN levels in the two groups significantly decreased after treatment,and the observation group was significantly lower than the control group(both P<0.01).CONCLUSION Jinkui Shenqi Pill combined with sacubitril-valsartan effectively improve the clinical symptoms of CHF patients,reduce their TCMSI scores,MWS and serum MSTN levels and improve cardiac functions and the effect is remarkable.
AIM To explore the application effect of ECG technology in the teaching of monitoring and evaluation of flight physiological parameters by analyzing the heart rate of students in the course of landing route flight on two different simulated flight platforms.METHODS Students Grade 2020 majoring in aviation and aerospace medicine served as research subjects and their heart rates in the pre-flight,takeoff,cruise and landing phases of the takeoff and landing route flight on the CJ-6 Simulation Flight Platform and the Microsoft Simulation Flight Platform were analyzed and the application effect of ECG technology in teaching monitoring and evaluation of flight biology parameters was evaluated.RESULTS The students'heart rate during the takeoff and landing route flight on the CJ-6 Simulation Flight Platform and the Microsoft Simulation Flight Platform was significantly higher than that before flight(P<0.01)and the heart rate on the CJ-6 Simulation Flight Platform was significantly higher than that on the Microsoft Simulation Flight Platform(P<0.05),indicating that the two simulation flight platforms brought certain flight load to the students and the flight load on the CJ-6 Simulation Flight Platform was higher than that on the Microsoft Simulation Flight Platform.Compared with that before flight,some difference was found in the students'heart rate in the takeoff,cruise and landing phases of flight on the two simulated flight platforms,but no significant difference was found in the heart rate in the cruise phase on the Microsoft Simulation Flight Platform.The heart rate in the landing phase was higher than that before flight and in the takeoff and the cruise phases,indicating that the landing phase brought the greatest flight load to the students.The students'heart rate in the take-off and the landing phases on the CJ-6 Simulation Flight Platform was significantly higher than that on the Microsoft Simulation Flight Platform(P<0.05),while no difference was observed in the cruise phase,indicating that the flight load on the CJ-6 Simulation Flight Platform was higher than that on the Microsoft Simulation Flight Platform in the take-off and the landing phases,and the flight difficulty on the two platforms in the cruise phase was equal.CONCLUSION The application effect of ECG technology in the practical teaching course of monitoring and evaluation of flight physiological parameters is good,which can not only improve students'scientific research ability and comprehensive quality,but also cultivate students'aviation medical thinking,which is conducive to the cultivation of military medical talents with practical and innovative ability in the new era under the background of"double first-class"construction.
AIM To evaluate the relationship between hypertension and partial sleep deprivation in young male soldiers.METHODS Young male soldiers under partial sleep deprivation were divided into two groups according to the days they had been partially sleep deprived.Blood pressure,pulse rate,age,height,body weight and other indicators were collected to compare the differences in blood pressure and pulse rate between the two groups,and the logistic regression was used to analyse the risk factors of hypertension.RESULTS Compared with the short-term PSD group,the long-term PSD group has older age(P<0.01),larger body mass(P<0.05),higher smoking index(P<0.05),and longer average PSD days(P<0.01);There was no statistically significant difference in BMI,conscription blood pressure,family history,smoking history,and SAS standard score.There was no statistically significant difference in pulse rate between the long-term and short-term groups.The detection rate of hypertension in the long-term group was higher than that in the short-term group(using Chi square segmentation,8.1%vs.1.4%,P<0.05),and the proportion of Normal height blood pressure was higher than that in the short-term group(using Chi square segmentation,54.7%vs.28.2%,P<0.01).The logistic regression analysis results showed that there is a higher risk of elevated blood pressure when the cumulative number of days of sleep deprivation exceeds 12 months(P<0.01).CONCLUSION Both systolic and diastolic blood pressure increased significantly when partial sleep deprivation lasted for more than 12 months.The proportion of high-normal blood pressure increased significantly when partial sleep deprivation lasted for more than 12 months.Increased blood pressure was associated with cumulative days of partial sleep deprivation.The risk of high blood pressure was significantly increased when partial sleep deprivation lasted.
AIM To investigate the relationship between hemoglobin glycation index(HGI)and in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in patients with type 2 diabetes mellitus.METHODS A retrospective analysis was performed on 134 patients with T2DM who underwent PCI in the Department of Cardiovascular Medicine,Taizhou People's Hospital from October 2019 to October 2022 and who underwent coronary angiography 8～24 months after surgery due to recurrence of chest pain or by doctor's advice.The patients were divided into two groups according to the examination results of angiography:ISR group(40 cases)and NISR group(94 cases).The differences of basic data,laboratory examinations,medication and interventional therapy between the two groups were analyzed.Multivariate logistic regression was used to analyze the influencing factors of ISR in patients with type 2 diabetes mellitus and receiver operating characteristic curve(ROC)was used to analyze the efficacy of HGI in predicting ISR in patients with type 2 diabetes.RESULTS The age,residual lipoprotein,glycosylated hemoglobin(HbA1c),HGI,Gensini score and total length of stent in ISR group were higher than those in NISR group,and the mean stent diameter was lower than that in NISR group,with statistical significance(P<0.05,P<0.01).Logistic regression analysis showed that HGI was an independent risk factor for ISR in patients with type 2 diabetes mellitus(OR=2.534,95%CI:1.023～6.281,P<0.05).ROC curve showed that the area under the curve of predicting ISR of patients with type 2 diabetes mellitus by HGI was 0.777.When HGI was 0.309,the predictive sensitivity was 72.5%and the specificity was 77.7%.CONCLUSION HGI is independently associated with the risk of ISR in patients with type 2 diabetes mellitus and HGI can be used as a clinical indicator to predict ISR in patients with type 2 diabetes mellitus.
