Vetiveria zizanioides roots were used from tradition in the treatment of various types of liver disorder. The objective of present study was to evaluate the oral acute and sub-acute toxicity (28 days) of the methanolic extract of Vetiveria zizanioides roots (MEVZ) in Wistar albino rats of both sexes. In the acute toxicity study, Wistar rats were treated orally with a single dose of 5 g/kg of body weight, and were observed for 14 days. Animals were monitored continuously for the first 4 h, for every 6 h for the next 24 h, upto 14 days. In the sub-acute toxicity study, MEVZ was administered orally at doses of 175, 550 and 1750 mg/kg daily for 28 days to Wistar albino rats. Treatment with MEVZ did not produce any toxic signs or deaths. Treatment with MEVZ did not alter either the body weight gain or the food and water consumption. The hematological and biochemical parameters did not show any significant differences in any of the parameters examined in both gender groups. Organ weight, necropsy and histopathological examination, did not reveal any remarkable treatment related changes. A no-observed adverse-effect level for MEVZ is 5 g/kg for rats in our study. Consumption of MEVZ for various medicinal purposes is safe.
Recently, COVID-19 caused mainly by the fast-spreading as compared with primary infections of new variant 'Omicron-SARS-CoV-2, the blind-spots, may have killed nearly 3 million only in India, and the whole world, opening a new chapter that has impacted our lives, and the highest number of Covid-19 deaths due to lack of vaccines gasping for air now. So, it is urgently needed the ‘Universal-Preventive-Emergency-Vaccine for All’ to tackle the awkward situation. Primarily, it has been already observed that the Ginger-MT-biomedicines, prepared from the rhizome of ginger (Zingiber officinale Rosc.), at an extremely-ultra-low-doses, highly effective against coronavirus controlling-COVID-19, and other diseases by increasing natural immunity. Now the aims and objective of the present ‘Notable-Case-Reports (NCR)’ are to see, record, and confirm the efficacy of the ‘High-Diluted-Traditional-Ginger-MT-Biomedicines (HDTGMTBM)’, against naturally occurring coronavirus infections or re-infections of the different-COVID-19-areas of the Burdwan-Municipality, Purba Bardhaman, West Bengal, India. And to highlight novel and significant future aspects of the study with the ‘Black Ginger’, the rhizome of Kaempferia parviflora. As a result in the ‘New-Year-2022; “‘Traditional-And-Black-Ginger-Biomedicines (TABGBM)’ May Be Act As ‘Notable-Universal-Preventive-Emergenc Vaccine (NUPEV)’ Against 'Future-A to Z-Diseases (FAZD)’ Enriched ‘Clinical-Case-Reports-Medical-Science-Technology-Communication-Research-Innovation-Global-Health-Ecology-Application (CCRMSTCRIGHEA)”. And in near future, both the Ginger MT-Biomedicines may easily tackle many diseases and complications. I will be ‘NUPEV’ due to medicines formulations, very-low-toxicity, potential efficacy, and different phytochemicals, eco-friendly-side-effects-free, cost-effective, easily prepare-able, easily available, easily-manufacture-able, easily-equitable, easily-marketable and easily-supply-able, etc. And in the future, it will be ‘Policy Initiative Potentially Life-Saving 'Future-A to Z-Vaccine for All’.
Background The surface energy the phospholipidic spherical membrane vs. pH, see Fig. 4A helped us to understand amphoteric character of cartilage surface (introduced together first time in literature) [4]. Methods The samples of articular cartilage were taken from the knees of an aged one to two-years-old ox. Friction coefficient (cartilage/cartilage) pair and the interfacial energy of a spherical lipid bilayer curves vs pH have “a bell-shaped curve” expressing amphoteric cartilage nature by the isoelectric point (IEP). Results It was found that the lowest energy values cover working conditions at pH 7.3 (±) 1.0 of natural joints, see Fig.4 A, B. The obtained “a bell-shaped curve” for (cartilage/cartilage) pair friction and spherical PLs bilayer is a novelty in this paper. Conclusions The observations have led to the conclusion that friction coefficient (cartilage/cartilage) pair and surface energy of a spherical lipid bilayer curves vs pH have (IEP) and expressing amphoteric surfaces character. The surface energy corresponds well with friction coefficient phospholipid amphoteric bilayer surface.
Purpose The topic of the presented paper concerns the human body and joint cartilage run-walk treatment implemented by the Electro-Magnetic (EM) and Acoustic Emission (AE) field. The thesis is proved here i.e. running in presence of a EM and AE field, increases dynamic viscosity of bio-lubricant liquids, thus increases energy burn, metabolism and finally it leads to the decrements of the body weight and hence it accelerates the slimming process. Material and Methods The research methods used in this paper include the following: EM field produced by a new Polish Apparatus MF-24, MT-3, Germany Magcell Arthro magneto electronic devices for the human body and joint cartilage treatment, Bone Dias Apparatus applied in AE therapy produced in Germany, ( Univ. Applied Science Giessen), Segmental Body Composition Analyzer Tanita MC 780MA, pedometer Garmin Ltd.2015.The author gained experience in Germany research institutes, and practical results were obtained after measurements and information from students and patients. Results The EM-therapy and AE results presented in this paper concern betterments during typical human cartilage diseases and causes of the effects of the slimming process gained before and after run-walk training. The run-walk training results presented in this paper concern the effects of the slimming process gained without and after electro-magnetic field therapy. Conclusions The main conclusions obtained in this paper are as follows: The run-walk training implemented by the electro-magnetic induction field and AE leads to the increments of the dynamic viscosity of synovial fluid and human sweat, changes the internal energy contained in the human body, muscle and cartilage, hence it accelerates the slimming process connected with the body weight decrements as well the betterments effects during the therapy.
The concept about the “therapeutic writing” has its beginning from an autobiographic work, realized in 2003, whose title is Letters to a real interlocutor. My sense. That autobiographic writing turned out to be therapeutic because it has helped the writer to develop her sharpest sufferings, to overcome traumas and to win old guilt. The therapeutic writing, meant as inner reveal, is essential to be able to understand also the physical signals that our body often give us as a reply, aware or not, to a pain we had lived and we are still living. The individual writing becomes a shared experience working in groups, where everybody gives his own personal contribution. The epistolary approach of the “therapeutic writing” consists in a bunch of letters (written to one’s self, to one’s mother etc.) used as therapeutic tools, in order for the writer to easily recall the meaningful episodes of his own existence, from his childhood to his adult age. The epistolary way becomes then the most appropriate way to remember our own emotions, our sorrows, the sufferings and our deepest feelings. The benefits, got with the individual writing, will become wider while reading and sharing personal experiences with others. The negative moods lived again by the person who tells about himself, will lose, line after line, the characteristic of anxiety and taboo, while the positive ones, even if shyly expressed, will find in the other people’s benevolence a further reason to go through again. All these constant efforts makes the “therapeutic writing” evolving into a performative character.
