Objective The purpose of this study was to evaluate the clinical application of TCD in type twodiabetic cases complicated with cerebral vascular pathological changes.Methods the patients in diabetic group include 45 cases with without intercurrent disease,53 cases with microangiopathy,44 cases cerebral infarct; 50 healthy volunteers as conctrol.The cerebral blood flow and Gosling pulsate index(PI) were measured by TCD apparatus and the patients were kept 60 months forward looking follow-up and the self regulation of cerebral artery were sequentially monitored.Results The results showed that the systolic peak velocity (Vs) and pulsate index (PI) in diabetic groups has significant difference compared with that in control (P0.05～0.001), the PI were increased significantly in patients with microangiopathy.The self regulation was out of balance that the artery has extensive cerebral spasm; during follow-up, there were 17 cases got unlethiferous cerebral infarct, 1 case got unlethiferous cerebral bleed, 3 cases got TIA; the incidence rate of cerebral vessels incident was higher in patients with abnormal encephalic blood flow compared with that with normal encephalic blood flow (P0.05).Conclusion TCD is a non-invasive and repeatable examination and is of great value and objective in diagnosing and evaluating the therapeutic efficacy and prognosis in diabetic patients complicated with cerebral vascular disease.
Objective To investigate the prevalence of H. pylori infection and the effectiveness of its eradication in Chinese patients with ITP. Methods H. pylori infection was found in 21 of 30 patients (70.0%) by 13C urea breath test. Results H. pylori was eradicated in 18 of the 21 infected patients (85.7%) by administration of a proton pump inhibitor and two kinds of antibiotics. In only one patient was medication discontinued due to skin rash on the 4th day of treatment. Platelet recovery was obtained in ten patients (55. 6%). In two patients with treatment failure, platelet recovery was obtained after successful re -eradication. In three patients without H. pylori infection, platelet counts did not significantly increase with the same treatment. On the other hand, eradication therapy did not affect platelet counts in patients with gastric ulcer. Conclusion H. pylori eradication can be used for initial treatment with tolerable adverse effects in some ITP patients.
Objective To evaluate the role of intracavernous vasoactive medicine and cavernosography in traumatic erectile dysfunction in judical authentication. Methods Intracavernous vasoactive medicine and cavernosography was made in 32 cases with traumatic erectile dysfunction, meanwhile the IIEF -5, the level of sexual hormones and nocturnal penile tumescence were assessed. Results 28 of 32 cases could erect after intracavernous papaverine, especially 24 cases could achieve sufficient tumescence, only 4 cases had non -tumescence, 4 cases showed venous drainage through cavernosography. The average score of IIEF -5 was 6.8. Conclusion Intracavernous vasoactive medicine and cavernosography is objective in judging traumatic erectile dysfunction in judical authentication.
Objective To observe the analgesia action of WHGS in mice and the relation between the action and dose. Method use the method of hot plate and turning round the body to determine the threshold of pain. Result WHGS can increase the threshold of pain markedly in mice and the action depends on its dose. Conclusion WHGS has obvious analgesia action.
Objective To study NF -κB activity, ICAM -1 and IL -6 level following severe acute pancreatitis -associated lung injury and the effect of betametasone on them in rats. Methods 36 SD rats were randomized into three groups each consisting of 12 rats:Sham -operated control group ( C group), severe acute pancreatitis group ( SAP group), betametasone group ( B group). SAP models were induced by retrograde injection of 5% sodium taurocholate(1 ml/kg) in the pancreatic duct. Group B were injected betametasone 10 ml/kg via vein after SAP models were made successfully. The activity of NF -κB and the level of ICAM -1 in lung were detected by immunohistochemical technique,and the level of IL -6 in serum and lung were measured by ELISA method. Results Histological change:There were some necrosis cells, more neu-trophiis infiltration, microvascular thrombus in both pancreas and lung tissue in SAP group, but less change in B group. The activity of NF -κB, the level of ICAM -1 and IL -6 in SAP group were significantly higher than those in C and B group(P 0.01) ,and the activity of NF -κB,the level of IL -6 of lung tissue in B group were higher than in C group (P 0.05). Conclusions Betametasone can inhibit the activity of NF -κB, decrease ICAM -1 and IL -6 level, alleviate severe acute pancreatitis -associated lung injury;animal model.
