Objective To study the clinical diagnostic value of the 13C-urea breath test in detecting Helicobacter pylori infection.Methods We selected 100 patients with upper abdominal discomfort who presented to the laboratory for examination from January 2022 to July 2023.All patients underwent rapid urease test(RUT)and 13C-urea breath test.Histological examination was used as the diagnostic gold standard to compare the diagnostic accuracy of the two methods for various diseases in patients,including the diagnostic positive rate.The diagnostic performance of the two methods(sensitivity,specificity,accuracy,negative predictive value,positive predictive value)was assessed.Results Among the 100 patients with upper abdominal discomfort,90 cases were confirmed by pathological examination.The 13C-urea breath test had a higher diagnostic positive rate for duodenitis and peptic ulcers compared to RUT(P＜0.05).There was no significant difference in the diagnostic positive rate between the two methods for gastric polyps,chronic gastritis,and gastric cancer(P＞0.05).The 13C-urea breath test had higher sensitivity,specificity,accuracy,positive predictive value,and negative predictive value compared to RUT.The specificity and accuracy of the two methods were significantly different(P＜0.05),while the sensitivity,negative predictive value,and positive predictive value were not significantly different(P＞0.05).Conclusion Both the 13C-urea breath test and RUT are effective diagnostic methods for detecting Helicobacter pylori infection,but the 13C-urea breath test has a higher diagnostic positive rate and overall diagnostic performance.
Objective To observe the anti-seepage effect of iodine contrast agent exosmosis alarm in the treatment of severe craniocerebral injury with intracranial high-pressure intravenous drip of mannitol.Methods A retrospective analysis was conducted on 100 patients with severe head injury and intracranial hypertension admitted to our hospital from January 2020 to January 2022,all of whom were treated with intravenous mannitol.Group B(50 cases)did not use an iodine contrast agent leakage alarm,while Group A(50 cases)used an iodine contrast agent leakage alarm.Compared the grading of mannitol extravasation,anxiety and comfort levels,and treatment satisfaction.Results ① The incidence of mannitol extravasation in group A was 4％,lower than the 18％in group B,with a statistically significant difference(P＜0.05).② Before intervention,the HAMA and GCQ scores of the two groups of patients were similar(P＞0.05);After intervention,the HAMA score decreased,the GCQ score increased,and the score in Group A was better than that in Group B(P＜0.05).④In terms of treatment satisfaction,94％of patients in Group A were higher than 80％in the control group,with a statistically significant difference(P＜0.05).Conclusion During the treatment of severe traumatic intracranial hypertension patients with an intravenous drip of mannitol,the use of iodine contrast agent extravasation alarm can prevent mannitol extravasation,help reduce anxiety,improve treatment comfort and satisfaction,and is worth promoting.
Objective To analyze the evaluation value of cervical vascular ultrasound and head and neck computed tomography angiography(CTA)on the degree of vascular stenosis and hemodynamics in patients with cerebral infarction and carotid artery stenosis.Methods A retrospective analysis was conducted on the clinical data of 72 patients with cerebral infarction and carotid artery stenosis admitted to the hospital from February 2022 to January 2023 as the study group were retrospectively analyzed as the study group,and 75 healthy individuals who underwent physical examinations in the hospital during the same period as the control group.Cervical vascular ultrasound and head and neck CTA examinations were performed on the two groups of study subjects.The degree of vascular stenosis of the subjects in the two groups was compared by digital subtraction angiography as the gold standard.Results The coincidence rate between neck vascular ultrasound and digital subtraction angiography was 67％,and the coincidence rate between head and neck CTA was 79％.The peak systolic and diastolic flow velocities of the internal carotid artery in patients with mild,moderate,and severe stenosis showed an increasing trend,and were significantly faster than those of the control group.The peak systolic and diastolic flow velocities of the internal carotid artery in patients with occlusion were significantly slower than those in the control group.The peak time and average passage time of cerebral blood flow in the control group,mild,moderate,severe stenosis,and occlusion patients showed an extended trend,while cerebral blood flow and volume showed a decreasing trend.Moreover,the peak time and average passage time of cerebral blood flow in severe stenosis and occlusion patients were significantly longer than those in the control group,mild,and moderate stenosis,and cerebral blood flow and volume were significantly lower than those of the control group,mild,and moderate stenosis(P＜0.05).There was no statistically significant difference in the comparison of the coincidence rate between neck vascular ultrasound and head and neck CTA(x2=2.848,P＞0.05).Conclusion The accuracy of carotid artery ultrasound and head and neck CTA in detecting vascular stenosis in patients with cerebral infarction and carotid artery stenosis is relatively high.Both neck vascular ultrasound and head and neck CTA can evaluate the hemodynamics of patients with cerebral infarction and carotid artery stenosis,and provide effective imaging information for clinical diagnosis and treatment.
Objective To explore the comparison of multimodal magnetic resonance imaging(MRI)and CT in ischemic stroke.Methods A retrospective analysis was conducted on 98 patients with acute cerebral infarction admitted to the Stroke Center of Jingdezhen Second Hospital from January 2021 to December 2022.They were divided into an MRI group and a CT group based on their examination methods.The MRI group underwent multimodal MRI scans,including diffusion weighted imaging(DWI),perfusion weighted imaging(PWI),and magnetic sensitivity weighted imaging(SWI).Clinical variables were evaluated using magnetic resonance signal processing software,A total of 58 patients were included.The CT group patients underwent CT plain scanning,and a total of 40 patients were included.Compare the time from onset to receiving thrombolytic therapy(DNT),neurological function,and prognosis between two groups of patients.Results The DNT of the MRI group was shorter than that of the CT group,with a statistically significant difference(P＜0.05).The cerebral infarction area scores of the MRI group patients were higher than those of the CT group patients,with statistically significant differences(P＜0.05).After 5 days of admission,the NIHSS scale score of patients in the MRI group was lower than that of patients in the CT group,with a statistically significant difference(P＜0.05).After 10 days of admission,the mRS score of the MRI group patients was lower than that of the CT group patients,with a statistically significant difference(P＜0.05).Conclusion Multimodal MRI can shorten the DNT time of ischemic stroke patients,thereby reducing the degree of neurological damage and improving their prognosis.
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目的 分析子宫切口瘢痕妊娠(CSP)患者清宫术前应用米非司酮、超声引导下甲氨蝶呤囊内注射联合治疗效果.方法 选取江苏省丰县人民医院于2021年1月至2022年10月收治的60例CSP患者,按治疗方法分为2组,即对照组30例,在术前服用了米非司酮;观察组30例,在术前服用米非司酮的同时,并采用超声引导下甲氨蝶呤囊内注射;对比2组清宫效果及相关指标.结果 观察组治疗效果97％高于对照组的73％,手术操作出血量、出血时间、术后血β-人绒毛膜促性腺激素(β-HCG)恢复正常、住院时间均低于对照组(P＜0.05).用药结束后检查发现观察组的妊娠囊最大长径、子宫内膜厚度低于对照组,子宫前壁下段的肌层厚度高于对照组,血β-HCG、糖类抗原(CA125)表达低于对照组(P＜0.05).结论 CSP患者清宫术前应用米非司酮、超声引导下甲氨蝶呤囊内注射联合治疗,可促进患者临床症状缓解,使血β-HCG及早恢复正常.
Objective To investigate the accuracy of magnetic resonance imaging(MRI)diffusion weighted imaging(DWI)in the differential diagnosis of brain metastases.Methods A total of 80 patients with brain metastases who were admitted to Jiyuan Second People's Hospital from January 2020 to December 2022 were selected as the observation group,and another 80 patients with brain glioma who were admitted to our hospital during the same period were selected as the control group.All patients were subjected to magnetic resonance plain scan and diffusion weighted imaging examination.The accuracy of MRI DWI in differential diagnosis of brain metastases and the apparent diffusion coefficient(ADC)values in different areas were analyzed,and the lesions and imaging performances of the two groups were compared.Results The accuracy,sensitivity and specificity of MRI DWI in the differential diagnosis of brain metastases were 97.50％,98.65％and 83.33％.The ADC values of the parenchymatous,cystic,marginal and peripheral edema areas of brain metastases were higher than those in the normal cerebral white matter area on the opposite side of the tumor(Tumor parenchyma vs tumor-contralateral normal white matter area t=26.833,tumor cystic lesion vs tumor-contralateral normal white matter area t=94.337,tumor margin vs tumor-contralateral normal white matter area t=57.883,and peritumor edema vs tumor-contralateral normal white matter area t=68.528,all P＜0.05).There were significant differences in lesion morphology and peripheral edema between the two groups(x2=42.776、42.524,all P＜0.05),while there was no significant difference in lesion margin(P＞0.05),the ADC value of DWI signal was close to the opposite side rate,the ADC value of DWI low signal was higher than that of the control group(x2=25.664、7.118,all P＜0.05),the rate of elevation of DWI high signal ADC value over the opposite side,and the DWI mixed signal ADC values over the contralateral side were lower than those of the control group(x2=25.507,36.923,all P＜0.05).Conclusion In the differential diagnosis of brain metastases,MRI DWI can further improve the diagnostic accuracy,and its imaging findings are significantly different from those of non-brain metastases,which can provide a reliable basis for the differential diagnosis.
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Objective To explore the value of different signs of plain scan CT in predicting the enlargement of hematoma in cerebral hemorrhage.Methods The clinical data of 85 patients diagnosed with cerebral hemorrhage admitted to Guixi People's Hospital from January 2020 to January 2022 were retrospectively studied.The onset time of the patients was ≤ 6 h,and the first CT examination was completed within 6 h,and the cranial CT examination was re-examined at 24 h,according to the results of the two CT examinations,the patients were divided into two groups:the group with enlarged hematoma(n=28)and the group without enlarged hematoma(n=57),the different signs of plain scan CT in the two groups were analyzed,and the influence signs of intracerebral hematoma expansion were analyzed by multifactorial logistic regression;meanwhile,ROC curve was drawn,and the area under the curve(AUC)was calculated to analyze the predictive value of different signs of plain scan CT for intracerebral hematoma expansion.Results There were significant differences in the first CT time,Glasgow coma score,hematoma volume and plain CT signs in patients with expanded hematoma group compared with those without expanded hematoma group(P＜0.05).However,there was no significant difference in gender,age,underlying diseases and location of hematoma between the two groups(P＞0.05).Multifactorial logistic regression analysis showed that the time of first CT,Glasgow coma score,hematoma volume,black hole sign,low density sign,island sign and mixed sign were the influencing factors of early hematoma enlargement(P＜0.05).According to ROC curve analysis,the A UC of black hole sign for predicting hematoma enlargement in patients with cerebral hemorrhage was 0.695,the sensitivity was 42.8％,and the specificity was 94.3％.Low density sign predicted the AUC of hematoma enlargement was 0.685,the sensitivity was 44.2％,and the specificity was 91.0％.The AUC of island sign for predicting hematoma enlargement was 0.679,the sensitivity was 48.9％,and the specificity was 95.4％.The A UC of the mixed signs predicting hematoma enlargement was 0.703,the sensitivity was 55.7％,and the specificity was 97.2％.Conclusion Plain CT for the first time showed that low-density sign,black hole sign,mixed sign and island sign were independent predictors of hematoma enlargement,indicating that patients with cerebral hemorrhage had a higher possibility of hematoma enlargement.
Objective To explore the relationship between homocysteine(Hey),tissue factor pathway inhibitors(TFPI),thrombomodulin(TM),and vascular cognitive impairment in patients with ischemic cerebrovascular disease.Methods A total of 160 patients with ischemic cerebrovascular disease admitted to the Neurology Department of Anyang Second People's Hospital in Henan Province from October 2021 to October 2022 were selected as the research subjects.According to the Mini-Mental State Examination(MMSE),the patients were divided into cognitive impairment group(105 cases)and cognitive normal group(55 cases).According to the different MMSE scores,the cognitive impairment group patients could also be divided into mild group(57 cases),moderate group(32 cases),and severe group(16 cases).Baseline data were collected from all study subjects,and the biochemical indexes and Hey,TFPI,and TM levels of all study subjects were tested.The baseline data and biochemical indicators of healthy control group research subjects,patients in the cognitively normal group,and patients with cognitive impairment were compared,and multivariate Logistic regression analysis was used to screen the risk factors of vascular cognitive impairment in patients with ischemic small vessel disease.Comparing the levels of Hey,TFPI,and TM in patients with mild,moderate,and severe cognitive impairment,and analyzing the relationship between Hey,TFPI,TM,and vascular cognitive impairment in patients with ischemic small vessel disease.Results The smoking history,proportion of hypertension,FBG,TC,Hey,and TM levels of patients in the cognitively normal group and cognitive impairment group were higher than those in the healthy control group,while TFPI levels were lower than those in the healthy control group.Additionally,the proportion of smoking history,FBG,TC,Hey,and TM levels of patients in the cognitive impairment group was higher than those in the cognitively normal group,and TFPI levels were lower than those in the cognitive normal group(all P＜0.05).The risk factors for vascular cognitive impairment in patients with the ischemic cerebrovascular disease were FBG,Hey,TM,and TFPI(OR=1.517,1.507,1.749,1.679,all P＜0.05).The Hey and TM levels in patients with moderate and severe cognitive impairment were higher than those in the mild cognitive impairment group,while TFPI levels were lower than those in the mild cognitive impairment group.Additionally,the Hey and TM levels in patients with severe cognitive impairment were higher than those in the moderate cognitive impairment group,and TFPI levels were lower than those in the moderate cognitive impairment group(all P＜0.05);Hey and TM were negatively correlated with MMSE scores and MoCA scores in patients with ischemic cerebrovascular disease,while TFPI was positively correlated with MMSE scores and MoCA scores in patients with ischemic cerebrovascular disease(all P＜0.05).Conclusion There is a close relationship between the increase of Hey and TM levels,as well as the decrease of TFPI levels,and the occurrence of vascular cognitive impairment in ischemic cerebrovascular disease.The detection of the above indexes can determine whether patients with ischemic cerebrovascular disease have vascular cognitive impairment,which can provide a reference for the development of clinical treatment plans.
Objective To investigate the application value of magnetic resonance DCE combined with T1-3D BRAVO enhancement in the diagnosis of prolactin-secreting pituitary microadenomas.Methods Forty-five patients with clinically diagnosed hyperprolactinemia in Xinyang Central Hospital from May 2021 to November 2022 were retrospectively included in the study.All patients underwent routine pituitary sequence plain scan plus dynamic contrast enhancement(DCE)coronal T1-FSE serial scanning,and enhanced coronal T1-3D BRAVO high-resolution scan was performed after DCE examination.The MRI images of all patients were sequentially combined to obtain three groups of images:Group A was conventional sequential plain scan+half-dose dynamic enhanced scan(DCE).Group B was routine sequential plain scan+coronal T1-3D BRAVO high-resolution scan.Group C consisted of Group A+coronal T1-3D BRAVO high-resolution scans.The images of the three groups were reviewed and analyzed by two physicians with greater seniority and rich diagnostic skills,and the efficacy of the three groups in detecting prolactin-secreting pituitary microadenomas was compared by McNemar test.Results There were 24 lesions(65％)detected in group A,16 lesions detected in group B,and 35 lesions(85％)detected in group C,and group C had higher sensitivity and diagnostic accuracy for the detection of lactating pituitary microadenomas than either group A and group B(P＜0.01).Conclusion DCE combined with T1-3D BRAVO technology can significantly improve the sensitivity of diagnosis of prolactin-secreting pituitary microadenomas.For patients with hyperprolactinemia,T1-3D BRAVO sequence can be an important addition to improve the detection of prolactin-secreting pituitary microadenomas.
根据《学术出版规范期刊学术不端行为界定(CY/T174-2019)》对论文作者学术不端行为类型进行界定,以下行为均属于学术不端,我刊投稿作者应规范写作,正确表述自己的科研成果. 1.剽窃(plagiarism):采用不当手段,窃取他人的观点、数据、图像、研究方法、文字表述等并以自己名义发表的行为.
Objective To analyze the predictive performance of SCr,CysC,and BNU on SAP complicated with AKI.Methods This article is a retrospective study,with cases including 100 SAP patients admitted to Tongxu County Hospital of Traditional Chinese Medicine from January 2021 to April 2023.SAP patients were divided into AKI group(40 cases)and non AKI group(60 cases)based on whether AKI was combined.General and clinical data of the two groups of patients were collected and compared,and the risk factors for SAP complicated with AKI were summarized through statistical univariate analysis and logistic multivariate regression analysis;The correlation between renal function indicators and SAP complicated AKI was tested by Spearman correlation coefficient,and the predictive efficacy of various renal function indicators on SAP complicated AKI was analyzed by plotting ROC and observing A UC.Results The results of the statistical univariate analysis showed that there were certain differences in age,shock,multiple organ failure,blood indicators,serum inflammatory factors,and renal function indicators between the two groups of patients(P＜0.05);The results of logistic multiple factor regression analysis showed that age ≥ 60 years old,combined with shock and multiple organ failure,WBC≥ 10 ×109/L,NLR≥10％,CRP≥100 g/L,PCT≥20 μg/L,SCr＞100 μmol/L,CysC＞1 mg/L,BUN＞8 μmol/L were risk factors leading to SAPcomplicated by AKI.According to Spearman correlation coefficient test,Scr,CysC,BUN indicators are positively correlated with the incidence of AKI;The ROC curve shows that abnormal increases in Scr,CysC,and BUN can lead to SAP complicating AKI(AUC＞0.85).Conclusion Abnormal blood indicators,inflammatory indicators,and renal function indicators are risk factors for SAP complicating with AKI in elderly patients,combined with concomitant shock,and multiple organ failure.The levels of Scr,CysC,and BUN are positively correlated with the incidence of AKI,and have a high predictive effect for SAP complicating with AKI.
Objective To detect and analyze pathogens bacteria characteristics and laboratory indexes in elderly patients with chronic obstructive pulmonary disease(COPD)combined with pulmonary infection.Methods A total of 72 elderly patients with COPD combined with pulmonary infection and 72 patients without pulmonary infection in the hospital were enrolled as infection group and control group from January 2021 and December 2022,respectively.The characteristics of pathogens bacteria and laboratory indexes of the patients were detected and analyzed.Results In the 72 sputum samples,proportions of Gram-negative bacteria(mainly on Acinetobacter baumannii)and Gram-positive bacteria(mainly on Staphylococcus aureus)were 85％and 15％,respectively.The results of drug sensitivity test showed that resistance rate of Acinetobacter baumannii to carbapenems was 18％(7/40).Compared with control group,patients in the infected group had higher levels of white blood cells(WBC),neutrophil percentage(NEUT％),C-reactive protein(CRP)and procalcitonin(PCT),and the differences were statistically significant(P＜0.05).Compared with control group,the level of serum IL-2 was lower in the infection group,and the differences were statistically significant(P＜0.05).Compared with the control group,levels of IL-6,IFN-γ and TNF-α were higher in the infection group,and the differences were statistically significant(P＜0.05).Conclusion Gram-negative bacteria are the main pathogens of pulmonary infection in with COPD,and timely testing of patients'laboratory indicators is needed to guide clinical diagnosis and treatment.
Objective To investigate the application value of surface sphenoidal electrodes combined with video eeg in the diagnosis of medial temporal lobe epilepsy.Methods One hundred patients with suspected medial temporal lobe epilepsy who attended our department for initial diagnosis from January 2021 to December 2021 were retrospectively analyzed,and performed REEG,VEEG and VEEG+surface pterionic electrodes,respectively.The detection rate of epileptic discharge was compared between the three tests,the detection rate of epileptic discharge in focal seizure and general seizure,and the localization results were compared with the MRI results.Results 93％(93/100)of VEEG combined with sphenoid electrode was higher than 23％(23/100)of REEG and 86％(86/100)of VEEG,and there was statistically significant(P＜0.05).In the diagnosis of general epilepsy,the detection rate of epileptogenic discharge by VEEG combined with sphenoid electrode was 88％(37/42),which was higher than that by REEG and VEEG[21％(9/42),83％(35/42)],and there was statistically significant(P＜0.05).In the diagnosis of focal epilepsy,94％(33/35)of VEEG combined with sphenoid electrode was more sensitive than 29％(10/35)and 83％(35/42)of REEG and VEEG,and there was statistically significant(P＜0.05).In patients with suspected mesial temporal lobe epilepsy,77％(77/100)of epileptiform discharges in temporal region were significantly higher than that in other brain regions(14/100).The one-sided detection rate of VEEG+sphenoid electrode was 59％(59/100),higher than that of REEG,VEEG and MRI(11％,54％,30％,11/100,54/100,30/100),and there was statistically significant(P＜0.05).Conclusion The surface sphenoidal electrode combined with VEEG has a positive effect on the detection rate of diagnosis of medial temporal lobe epilepsy,and plays an important role in the treatment of medial temporal lobe epilepsy.
Objective To investigate the value of serum microrna-192(miR-192),microrna-221(miR-221),neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)in children with severe pneumonia complicated with sepsis.Methods From October 2020 to March 2022,256 children with severe pneumonia were selected from Yanqing District Hospital.Among them,104 children with sepsis(experimental group)and the remaining 152 children with sepsis(control group)were selected.The subclinical indexes were calculated by measuring blood routine with sysmex XN-9100,and the serum levels of miR-192 and miR-221 were detected by real-time fluorescence quantitative polymerase chain reaction(qRT-PCR),and the differences of miR-192,miR-221,NLR and PLR were compared between the two groups,the correlation of miR-192,miR-221,NLR and PLR was analyzed by Person,and the diagnostic value of miR-192,miR-221,NLR and PLR in severe pneumonia with sepsis was evaluated by ROC curve.Results The expression levels of miR-192 and miR-221 in children with severe pneumonia combined with sepsis were lower than those in control group,while the expression levels of NLR and PLR were higher(t=16.272,P＜0.01;t=10.972,P＜0.01;t=15.352,P＜0.01;t=22.278,P＜0.01).Pearson correlation analysis showed that miR-192 was negatively correlated with the expression of NLR and PLR(r=-0.402,P＜0.01;r=-0.432,P=0.001),and miR-221 was negatively correlated with the expression of NLR and PLR(r=-0.341,P=0.002;r=-0.458,P=0.001).The AUC of miR-192,miR-221,NLR and PLR for children with severe pneumonia combined with septicemia were 0.863,0.769,0.792 and 0.787,respectively.The AUC of combined index diagnosis was 0.955.Conclusion Through the analysis of the detection of various indicators of children with severe pneumonia combined with septicemia,the levels of miR-192 and miR-221 were decreased,while the levels of NLR,PLR and expression of miR-221 were increased,and they were in line with the children's clinical symptoms,so the combination of the detection can improve the specificity and sensitivity of diagnosis in children with severe pneumonia complicated with Sepsis,timely treatment,rapid relief of the symptoms of children,which is worthy of clinical promotion.
Objective To explore the diagnostic value of serum carbohydrate antigen 19-9(CA19-9),alpha fetoprotein(AFP),carbohydrate antigen 50(CA50)combined with liver function indicators in liver metastasis of colon cancer.Methods A retrospective analysis was conducted on the clinical data of 108 colorectal cancer patients admitted to the Fifth People's Hospital of Anyang from August 2020 to August 2022.All enrolled patients were divided into a metastatic group(35 cases)and a non metastatic group(73 cases)based on whether their tumor cells had metastasized to the liver.The serum CA19-9,AFP,CA50,and liver function indicators of two groups of patients were detected.The baseline data,serum CA19-9,AFP,CA50,and liver function indicators of the two groups of patients were compared.Using multifactorial logistic regression analysis to screen the risk factors for postoperative liver metastasis in colorectal cancer patients.Using the receiver operating characteristic(ROC)curve to analyze the risk factors for liver metastasis in patients with serum CA19-9,AFP,CA50 and liver function indexes to diagnose liver metastasis of colorectal cancer.Results The serum CA19-9,AFP,CA50,Alkaline phosphatase(ALP),7-glutamyl transpeptidase(GGT),lactate dehydrogenase(LDH)levels in the metastatic group were[(168±11)kU/L,(31.8±1.7)ng/ml,(33.2±2.6)U/ml,(88±4)U/L,(54±7)U/L,(294±11)U/L],which were higher than those in the non metastatic group[(14±6)kU/L,(17.0±1.6)ng/ml,(17.7±1.3)U/ml,(68.2±5.1)U/L,(17±4)U/L,(180±11)U/L](t=75.551,42.670,33.827,21.131,27.143,51.860,all P＜0.05).The results of univariate analysis showed that the proportion of patients in the metastatic group with TNM staging of stage Ⅲ～Ⅳ,the depth of infiltration encroached on the plasma membrane layer,and the degree of tissue differentiation was low or moderately differentiated The percentage of patients(68.6％,71.4％,and 85.7％)increased compared to the non metastatic group(30.1％,24.7％,and 13.7％)(x2=14.292,21.597,and 52.614,all P＜0.05).The results of multivariate logistic regression analysis showed that the risk factors for postoperative liver metastasis in colorectal cancer patients were TNM stage,CA19-9,AFP,CA50,ALP,GGT,and LDH(all P＜0.05).The ROC curve analysis results show that the area under the curve(A UC)value of the combined detection of serum CA19-9,AFP,CA50,ALP,GGT,and LDH indicators was 0.887,which was higher than A UC value of the single detection of the above indicators.The sensitivity,specificity,and accuracy of the combined detection were 81.2％,87.3％,and 83.8％,respectively,which were higher than those of the single indicator detection.Conclusion There is a close relationship between serum levels of CA19-9,AFP,CA50,ALP,GGT,and LDH in patients with liver metastasis of colon cancer.The above indicators show an upward trend in colorectal cancer patients,and the combined detection of these indicators makes up for the shortcomings of single indicator detection,with high diagnostic value,which can provide reference for the development of clinical treatment plans for this disease.
Objective To investigate the effect of low-dose colchicine treatment on patients with angina pectoris combined with acute hyperuricemia,as well as the changes in blood uric acid,angiotensin Ⅱ,and C-reactive protein levels,in order to provide reference basis for clinical treatment of angina pectoris combined with acute hyperuricemia.Methods Eighty-two patients with angina pectoris combined with acute hyperuricemia admitted to Puyang Traditional Chinese Medicine Hospital from June 2021 to February 2023 were selected as the study subjects.According to method of randomized numerical table,82 patients were divided into the reference group(41 cases)and the observation group(41 cases).The reference group was treated with high-dose colchicine orally,while the observation group was treated with low-dose colchicine orally,with a treatment period of 1 week.The clinical effects of the two groups,including the scores of the Digital Pain Scale(NRS)before and after treatment for 3 and 7 days,as well as the levels of blood uric acid,angiotensin Ⅱ,red blood cell sedimentation rate,inflammatory factor indicators before and after treatment,as well as the occurrence of headache,nausea and vomiting,liver dysfunction,and abdominal diarrhea during the treatment period,were compared.Results The clinical effective rate of the observation group after one week of clinical treatment was 95％,which was higher than that of the reference group,which was 83％,and there was no statistically significant difference(P＞0.05);Compared with the pre-treatment period,the NRS score,blood uric acid,angiotensin Ⅱ,and erythrocyte sedimentation rate in both groups decreased after 3 and 7 days of treatment(P＜0.05).However,after comparison,there was no statistically significant difference between the above indexes of the two groups of patients(P＞0.05);Compared to before treatment,after clinical treatment,it was found that the levels of C-reactive protein,interleukin-1,and interleukin-6 in the two groups decreased,and the observation group was lower than the reference group;Compared to the control group,the total incidence of headache,nausea and vomiting,liver dysfunction,and diarrhea in the observation group decreased(P＜0.05).Conclusion The clinical effects of different doses of colchicine in treating patients with angina pectoris combined with acute hyperuricemia are equivalent,and all of them can achieve the effect of alleviating pain symptoms in patients.Among them,low-dose colchicine treatment is more effective in reducing inflammatory damage and reducing adverse reactions,and It can also reduce adverse reactions,with good safety.
Objective To investigate the diagnostic efficacy of multi-detector spiral CT combined with MRI in patients with primary liver cancer.Methods Retrospectively analyzed the clinicopathological and imaging data of 68 patients with pathologically confirmed primary hepatocellular carcinoma in Third Hospital of Zhangzhou from July 2021 to December 2022,all of whom were examined by MDCT and MRI,with the clinicopathological examination as the gold standard.The detection rate of disease,lesion detection,and different liver cancer types were compared between the single examination method and the multi-detector spiral CT combined MRI examination.Results The detection rate of multi-detector spiral CT combined with MRI was higher than that of single method(P＜0.05).A total of 137 lesions were confirmed by pathology,and the detection rate of multi-detector spiral CT combined with MRI was higher than that of the single detection method(P＜0.05).There were 23 cases of massive liver cancer,24 cases of nodular liver cancer,and 21 cases of diffuse liver cancer diagnosed by pathology.There was no difference in the detection rate of massive liver cancer between the single method and multi-detector spiral CT combined with MRI(P＞0.05).The detection rate of multi-detector spiral CT combined with MRI for nodular and diffuse liver cancer was higher than that of the single method(P＜0.05).Conclusion In the diagnosis of primary liver cancer,the detection rate of multi-detector spiral CT combined with MRI is higher,which can provide important evidence for making accurate diagnosis and treatment of diseases as early as possible.
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