目的:探讨米氮平联合氟西汀治疗抑郁症对患者抑郁情况、睡眠质量及认知功能的影响.方法:选取2017年4月—2019年5月我院收治的86例抑郁症患者作为观察对象,将观察对象按随机数字表法分为对照组和观察组各43例.对照组给予氟西汀进行治疗,观察组在对照组的治疗基础上给予米氮平治疗,两组患者均连续治疗3个月.比较两组患者治疗前后抑郁情况、认知功能、睡眠质量变化情况、治疗效果及不良反应发生情况.结果:治疗后两组汉密尔顿抑郁量表(HAMD)评分较治疗前明显下降(P＜0.05),蒙特利尔认知评估量表(MoCA)评分较治疗前明显上升(P＜0.05),且观察组HAMD评分显著低于对照组(P＜0.05),观察组MoCA评分明显高于对照组(P＜0.05);治疗后观察组与对照组的临床总有效率分别为93.02％、72.09％,观察组显著高于对照组(P＜0.05);与治疗前比较,治疗后两组匹兹堡睡眠质量指数量表(PSQI)评分显著降低(P＜0.05),且观察组显著低于对照组(P＜0.05);治疗后观察组的生理功能、躯体功能、社会功能及情感职能评分均显著高于对照组(P＜0.05);观察组与对照组的不良反应发生率分别为4.65％、23.26％,观察组明显低于对照组(P＜0.05).结论:米氮平联合氟西汀可有效缓解抑郁症患者的抑郁情况,改善患者睡眠质量,提高患者认知功能,且安全有效,值得临床推广应用.
目的:探讨产科下肢深静脉血栓(DVT)危险因素评估表及预防措施记录表在临床护理中的应用效果.方法:收集2019年6月—2020年6月我院产科收治的1 000例孕产妇,随机分为对照组和护理组,每组各500例,对照组采用常规护理,护理组采用产科DVT危险因素评估表对孕产妇DVT形成风险因素进行评估,根据评估结果采用DVT预防措施记录表,分别对DVT低、中、高危孕产妇采取相应针对性的预防护理措施.比较两组孕产妇平均住院天数、DVT、肺血栓栓塞症(PTE)及下肢肿胀发生率及护理满意度情况.结果:采用产科DVT危险因素评估表进行风险评估,根据患者评估结果给予针对性的预防护理措施,护理组在平均住院天数、DVT和下肢肿胀发生率明显低于对照组(P＜0.05);护理组护理满意度评分明显高于对照组(P＜0.05).结论:运用产科DVT危险因素评估表对孕产妇进行DVT风险评估,并根据评估结果采用预防措施记录表,针对性地落实预防护理措施对DVT预防有积极作用,可以缩短住院天数、提升护理质量、降低DVT和下肢肿胀发生率,值得推广应用.
目的:探讨老年肺癌患者化疗后应用超声心动图进行心肌毒性评价的效果.方法:收集2016年1月—2020年1月我院收治的老年非小细胞肺癌化疗患者79例,化疗前后均采用超声心动图检查,并对患者血清中氧化应激指标含量、凋亡应激指标含量以及心肌毒性标志物进行测定,比较患者化疗前后的血清指标和超声心动图检查结果.结果:化疗后患者心肌毒性标志物、氧化应激指标含量、心动图检查结果及凋亡应激指标含量与化疗前比较,差异均有统计学意义(P＜0.05).结论:为老年肺癌化疗患者采用超声心动图检查,对其化疗后心肌毒性反应进行评定,可准确判断患者病情变化情况,为患者后续治疗提供依据.
目的:探讨芬太尼与阿芬太尼用于腹腔镜手术的临床麻醉效果.方法:选取2018年12月—2019年12月在我院进行腹腔镜手术的患者68例,随机分为对照组与观察组各34例.对照组给予芬太尼麻醉,观察组给予阿芬太尼麻醉.比较两组患者麻醉诱导前、麻醉诱导后及检查结束后5 min的平均动脉压(MAP)、心率(HR)、血氧饱和度(SPO2).结果:诱导前,两组患者MAP、HR及SPO2比较,差异均无统计学意义(P＞0.05);诱导后,观察组患者MAP、HR及SPO2均低于对照组(P＜0.05);检查结束后5 min,观察组患者MAP、HR及SPO2均高于对照组(P＜0.05).结论:腹腔镜手术中相较于芬太尼麻醉来说,阿芬太尼的麻醉效果更为迅速,且患者术后恢复速度快,预后更为理想,值得临床推广应用.
Objective: This study is aimed to investigate the effects of sodium valproate and topiramate on electroencephalogram discharge and glucose and lipid metabolism in children with epilepsy. Methods: According to the random number table method, 91 cases of epileptic children admitted to our hospital from February 2018 to February 2020 were divided into two groups. The control group（n=45） was treated with sodium valproate, while the observation group（n=46） was treated with topiramate. The therapeutic effects of the two groups were compared.Results: The total effective rate in the observation group was 95.7%, which was higher than 73.3% in the control group（P ＜ 0.05）; After treatment, the immune function of the observation group was better than that of the control group（P ＜ 0.05）; The number of epileptic discharges within 40 minutes and within 1 minute in the observation group after treatment α、β、δ、θ The number of waves in different frequency domains was significantly lower than that in the control group（P ＜ 0.05）; After treatment, the cognitive function scores in the observation group were higher than those in the control group（P ＜ 0.05）; After treatment, the indicators of glucose and lipid metabolism in the observation group were better than those in the control group（P ＜ 0.05）; There was no statistically significant difference in the incidence of adverse reactions between the two groups（P ＞ 0.05）.Conclusion: Sodium valproate and topiramate have their respective advantages in the treatment of pediatric epilepsy, and the dosage should be strictly controlled in clinical use to reduce cognitive impairment and the effects of glucose and lipid metabolism.
