Objective: To investigate the influence of continuity of care on self- care agency and sleeping quality in patients with type 2 diabetes. Methods: 50 cases of type 2 diabetes from January 2012 to July 2013were divided into control group and observation group. The control group received routine hospital care,the observation group was given continuity of care after discharge. Self- care agency and sleeping quality were observed in two groups. Results: After 3 moths,the Measurement Scale scores of observation were higher than the control group,and sleeping self- assessment was lower than the control group( P 0. 05). Conclusion: The continuity of care significantly improved self- care agency and sleeping quality in patients with type 2 diabetes.
脂质代谢重编程已成为肿瘤研究领域的热点,异常脂质代谢与恶性肿瘤发生、发展密切相关,通过调节异常脂质代谢途径可有效防治恶性肿瘤,但目前相应药物尚处于研发阶段.从中医理论来看,异常脂质代谢相当于"浊邪"(痰、湿、瘀等邪气聚集),既是致病因素,又是病理产物,其贯穿于恶性肿瘤的发生、发展始终,且"浊邪"的产生也与恶性肿瘤病机"本虚标实"相吻合,"扶正祛邪"法,可有效抑制恶性肿瘤生长,又可调节异常脂质代谢.基于此,本研究以脂质代谢重编程为着眼点,探讨"扶正祛邪"法在治疗恶性肿瘤和调节异常脂质代谢(祛除"浊邪")中的应用和潜在机制.
帕金森病(PD)是常见于中老年的神经系统变性疾病,因其症状复杂,病情进展缓慢,平均期望寿命长等特点,有必要制定长期系统的治疗策略.近期临床研究已经表明中西医结合治疗PD具有明确优势.马羽教授基于中西医结合的思维与方法,通过医工结合、多学科联合的方式,以PD患者临床症状及个体化问题为导向,以提高患者生命质量为主线,建立"帕金森病中西医整合诊疗体系",以期为医生临床诊疗PD提供参考.
Objective:To determine the histological effect of Panax notoginseng saponin（PNS） on heterotopic ossification（HO） of Achilles tendon in rats and identify the underlying mechanism based on transforming growth factor-β 1 （TGF-β 1 ）/Sma-and Mad-related protein（Smad） 2/3 signaling pathways.Methods:A total of 126 Sprague-Dawley（SD） rats were randomly divided into seven groups:a normal control group,a sham operation group,a model group,a western medicine treatment group,a high dose group,a medium dose group,and a low dose group,with 18 rats in each group.After receiving HO modeling surgeries,rats were treated with PNS in different concentrations,western medicine,or normal saline by gavage for two weeks.The incidence of HO was evaluated by X-ray and CT scan at 2,5,and 10 weeks postoperatively.A series of general histological staining methods,including hematoxylin-eosin（HE） staining,Masson’s trichrome staining,and Safranin O-fast green staining,were used to evaluate the histological changes in HO lesions.The expression of TGF-β 1 ,phosphorylated Smad 2（p-Smad2）,and p-Smad3 in the local lesion was compared among groups by immunohistochemistry.Results:At 10 weeks postoperatively,results of the X-ray examination showed that there was no significant difference in the rate of bone formation among all groups receiving HO modeling surgeries（P＞0.05）.At two weeks after surgery,there was a significant increase in Achilles tendon cells in rats（P ＜0.05） and a disturbed arrangement of Achilles tendon fibers.A large number of proliferating hypertrophic chondrocytes were observed at five weeks and a large amount of mature ectopic bone tissues was formed at 10 weeks.The relative bone mass at 10 weeks in the medium dose group was significantly lower than that in the model group（P ＜0.05）.The results of immunohistochemistry showed that the postoperative expression of TGF-β 1 ,p-Smad2,and p-Smad3 in the sham operation group was significantly higher than that in the normal control group（P ＜0.01）.Compared with the model group,the medium dose group exhibited significantly decreased TGF-β 1 expression two weeks after surgery（P ＜0.05） with delayed peak expression.Conclusion:The expression of TGF-β 1 increased significantly after the HO modeling surgery of the Achilles tendon in rats.A certain concentration of PNS can reduce the relative bone mass of ectopic bone tissues,which may be related to the possibility that PNS delayed the peak expression of TGF-β 1 and down-regulated its expression.
Objective:To explore the clinical efficacy of modified Dahuang Mudan decoction in the treatment of hyperuricemia in patients with chronic kidney disease(CKD).Methods:Retrospective analysis was performed,42 cases of hyperuricemia with CKD treated with allopurinol tablets in Qinhuangdao Traditional Chinese Medicine Hospital from October 2019 to June 2022 were includ-ed as the control group;46 cases of hyperuricemia with CKD who received the treatment of modified Dahuang Mudan Decoction combined with allopurinol tablets in the same period were included as the observation group,and they were both treated for 8 weeks.The 24-hour urine protein quantification,24-hour urine uric acid level,clinical efficacy,renal function indicators such as se-rum creatinine(SCr),blood urea nitrogen(BUN),glomerular filtration rate(GFR),uric acid(UA),traditional Chinese medicine syndrome score,and incidence of adverse reactions between the two groups were compared.Results:The total effective rates of the observation group and the control group were 91.30％(42 cases/46 cases)and 66.66％(28 cases/42 cases),respectively.The re-nal function indicator SCr were(98.21±14.01)μmol/L and(121.52±29.14)μmol/L,respectively;BUN were(7.56±0.63)mmol/L and(9.24±0.98)mmol/L,respectively;serum UA were(681.43±106.73)μmol/L and(549.63±87.49)μmol/L,respectively;GFR were(28.97±9.23)mL/(min·1.732)and(24.56±8.44)mL/(min·1.732),respectively,and the differ-ence was statistically significant(P＜0.05).The uric acid metabolism indicator 24-hour urine protein quantifications were(1.01± 0.87)g and(1.94±1.12)g,respectively;24-hour uric acid levels were(398.31±32.47)μmol/L,(456.32±40.58)μmol/L,respectively,and the difference was statistically significant(P＜0.05).TNF-α levels were(45.27±5.93)μg/L and(88.62± 8.71)μg/L,respectively;IL-6 levels were(41.73±6.21)ng/L and(82.56±8.98)ng/L,respectively;CRP levels were(7.97±0.38)mg/L and(14.22±1.89)mg/L,respectively,and the difference was statistically significant(P＜0.05).The tradi-tional Chinese medicine(TCM)symptom scores of the two groups were both improved,and that of the observation group was lower than that of the control group;the differences were both statistically significant(P＜0.05).There were no adverse drug reactions in the observation group and the control group.Conclusion:The treatment of hyperuricemia in patients with CKD with modified Dahuang Mudan Decoction combined with allopurinol tablets is more effective and safe than that with allopurinol tablets alone.
