Migraine is a common clinical cause of primary neurovascular headache, which is closely related to psychosocial factors and has a great impact on people's daily life. The pathogenesis of migraine is diverse, and the more mature mechanisms include vascular theory, neuronal theory, inflammatory mediator theory, neurotransmitter theory, neurotrophic factor, central sensitization and activation of the limbic system of the thalamus, and dopaminergic system-related gene theory. Chinese medicine believes that headache can occur when the evil of the six leucorrhea attacks the top of the body, stagnating the evil qi and blocking the clear yang, or when internal injuries lead to the reversal of qi, and blood, stagnation of the meridians, and loss of nourishment for the brain. Chuanxiong, as a common clinical herb, has the function of promoting blood circulation, dispelling wind, and relieving pain. Based on the pattern of medication used in the treatment of migraine during the Song, Jin, and Yuan dynasties, it was found that Chuanxiong was used very frequently in the treatment of headaches, headwinds, first wind, and migraine. In addition, modern pharmacological studies have found that the main components of Chuanxiong Ligusticum include tetramethylpyrazine (Chuanxiongzin), ferulic acid, volatile oil, ligustilide, chuanxiong lactone and alkyl phenyl peptides such as butenolide and that Chuanxiong Ligusticum has analgesic, anti-inflammatory, antioxidant, anti-tumor, anti-coagulant, anti-depressant, anti-aging, anti-atherosclerosis, cytoprotective, and cardiac function improving effects. In conclusion, Chuanxiong has great research potential in the treatment of migraine. In this paper, we mainly classify and summarize the effects of Chuanxiong in the treatment of migraine and provide a scientific basis for the application of Chuanxiong in the treatment of migraine.
With the rapid development of society and the increase of human pressure, the occurrence of diseases has become more common. Insomnia is gradually known as a common clinical disease. The occurrence of insomnia is gradually unrelated to age, and the incidence rate is increasing year by year. Insomnia brings a heavy burden to human life and work, and even causes other diseases. Therefore, it is necessary to treat insomnia efficiently. Western medicine believes that insomnia is a disorder of the sleep cycle, which may change the sleep phase due to external factors. The treatment method is mainly based on taking western medicine, but the patients have most adverse reactions in clinical practice and low acceptance. Traditional Chinese medicine believes that insomnia is a change in sleep caused by the imbalance of yin and yang and qi and blood. There are various pathological factors and many treatment methods. In clinical practice, patients have less discomfort and high acceptance. Therefore, this paper is based on the treatment of insomnia in traditional Chinese medicine, and strives to prove the therapeutic effect of traditional Chinese medicine on insomnia.
腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,1BS-D)是临床常见的功能性紊乱疾病,西医尚未明确阐明其发病机制,治疗上尚缺乏有效的治疗手段.中医药具有多靶点、多途径、多通路等优点,可发挥综合治疗作用,能有效改善IBS-D的临床疗效及症状,并可降低复发率.在中医辨证理论中,脾肾阳虚为IBS-D的重要病机,贯穿IBS-D病机演变的始终.温肾健脾法作为治疗IBS-D的经典治法,被广泛应用于中药复方治疗、针灸治疗、穴位贴敷治疗、中西医结合治疗、内外合治疗法及其他中医特色疗法治疗IBS-D当中,且疗效显著.结合目前相关研究,温肾健脾法发挥治疗作用的机制可能与降低内脏敏感、调节脑肠互动、调控机体免疫及减轻炎症反应有关.文章主要从温肾健脾法治疗IBS-D的临床应用及作用机制两方面概述其研究进展,以期为临床治疗LBS-D提供更好的方案及思路.
Objective To observe the therapeutic effect of autologous platelet-rich plasma on senile knesteoarthritis and compare its advantages with medical chitosan. Methods Thirty elderly patients with knee osteoarthritis treated with platelet-rich plasma in Jinqiu hospital of Liaoning province from 2019 to 2021 were randomly selected as the experimental group and 30 patients treated with medical chitosan as the control group. The knee VAS score,Lysholm score and WOMAC score of the two groups were recorded before surgery,3 months,6 months and 12 months after surgery,and the improvement of postoperative knee function was compared through statistical analysis. The therapeutic effects were compared between the two groups by knee MRI,blood cell C-reactive protein and white blood cell count before and 2 weeks after operation,and the causes were analyzed. Results（1）Scale score:Through statistical analysis,the VAS,Lysholm and WOMAC scores of the two groups at 3,6 and 12 months after operation were significantly improved compared with those before operation（P＜0.05）;there was no statistically significant difference in VAS,Lysholm,and WOMAC scores between the two groups after operation,and the treatment between the experimental group and the control group at 3 and 6 months after operation（P＞0.05）. During the follow-up in December,the curative effect of experimental group was significantly better than that of control group,and the VAS,Lysholm and WOMAC scores were significantly improved compared with those before operation（P＜0.05）.（2）Inflammation control:Two weeks after operation,the C-reactive protein and white blood cell count of the experimental group and the control group decreased significantly compared with those before operation（P＜0.05）,and the inflammatory index control of the experimental group was significantly better than that of the control group（P＜0.05）.（3）Nuclear magnetic resonance results:Imaging comparison showed that two weeks after platelet-rich treatment,the knee joint environment improved significantly,inflammatory indicators were well controlled,and subchondral bone edema absorption was obvious.（4）Adverse events:1 patient with autologous PRP treatment had mild adverse reactions,and 3 patients in the chitosan group had mild adverse reactions. None of the 4 patients had drug or physical intervention,and the symptoms disappeared 1-2 days later. Conclusion Autologous platelet rich plasma and medical chitosan have good therapeutic effect on senile knee osteoarthritis. Platelet-rich plasma was superior to medical chitosan in the early postoperative improvement of arthritis. When platelet-rich plasma was followed up at the 12 months after operation in the treatment of elderly knee osteoarthritis,the clinical therapeutic effect of knee joint was better than that of medical chitosan,and the safety and adverse reactions were less.
恶性肿瘤发病率与病死率日益递增,对人类健康造成巨大威胁,已成为全球关注的公共卫生问题.目前,以放化疗为主治疗肿瘤疾病的方法因其不良反应大、预后不良及肿瘤耐药等短板,使肿瘤治疗遭遇瓶颈.中医药以其多途径、多靶点、多通路调控的优势在抗肿瘤方面崭露头角.石蒜碱是石蒜科植物的主要有效成分,研究表明,石蒜碱具有显著的抗肿瘤活性,对肾癌、肝癌、结直肠癌、肺癌、宫颈癌、前列腺癌、骨髓瘤、白血病、乳腺癌等均有抑制作用.文章就石蒜碱近年来抗肿瘤相关研究进行综述,对其抗肿瘤作用机制进行归纳总结,以期为其抗肿瘤开发利用提供一定参考.
