The determination of the concentrations of free amino acids and their derivatives in serum and in blood lymphocytes of rats was performed in 3 h and 24 h after single intragastric administration of tauzinc in the dose of 400 mg / kg. We found the reduction in the total number of amino acids in blood serum, the number of branched chain amino acids (BCAA), as well as the reduction of the proportion of BCAA in the total pool of essential amino acids. The amount of proteinogenic amino acids in the serum reduced as well. In blood lymphocytes, on the contrary, the amount of proteinogenic amino acids in 3 h after the injection of the drug reliably increased, however, in 24 h the total number of free amino acids in blood lymphocytes did not differ from the control values. Mainly, the levels of nonessential amino acids increased, and in 24 h reliable decrease in the concentrations of essential amino acids was observed, which manifested itself in the increased ratio of the sum of proteinogenic amino acids to nonproteinogenic derivative amino acids. In animals treated with tauzinc marked change in the concentrations of methionine, cystathionine and taurine was noted. Thus, single intragastric administration of tauzinc impoverishes the pool of free amino acids and their derivatives in blood serum, increasing at the same time their content in blood lymphocytes.
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