The article deals with studying the degree of increase of the von Willebrand factor and the concentration of endothelin-1 in blood plasma in the subgroups of patients with diabetes mellitus formed depending on of type of disease and presence of phenotype with affection of kidneys. The sampling of 176 patients with diabetes mellitus (65 patients with diabetes mellitus type I, 111 patients with diabetes melli-tus type II) was examined. The control group consisted of 30 healthy persons. In the capacity of biochemical markers of endothelium dysfunction the activity of the von Willebrandfactor and the concentration of endothelin-1 in blood were consid-ered. In all patients with diabetes mellitus the biochemical characteristics of endo-thelium dysfunction are present manifesting by increase of concentration of endo-thelin-1 in blood which is especially expressed under disease phenotype with affec-tion of kidneys. Despite of the apparent lesion of endothelium in patients with dia-betes mellitus compromised with diabetic nephropathy the thrombocytes aggrega-tion induced by ristomicine does not undergo natural changes. Hence, to consider in these patients the increasing activity of the von Willebrandfactor as a reliable marker of endothelium dysfunction is not seemed possible.
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