This three-week open uncontrolled study included 34 men (mean age 53.14+-1.19 yr) with coronary heart disease (CHD) and insulin resistance (HOMA >2. 77); it was designed to estimate effect of amlodipine on transcapillary oxygen metabolism (TCOM). Multivascular stenosing coronary atherosclerosis was managed by aortocoronary bypass surgery. Traditional methods applied in specialized cardiological clinics were supplemented by TCOM measurement using a PA-2 polarograph (Czech Rep.). Polarography revealed deterioration of TCOM parameters including permeability of hemocapillaries, adaptive reserves of the microcirculatory bed, and oxygen supply to the tissues. Amlodipine therapy demonstrated high antianginal potency of this drug and its ability to improve TCOM

Aim. To comprehensively study hemostasis pathology and its association with the laboratory markers and mediators of inflammation in patients with metabolic syndrome (MS).Subjects and methods. One hundred and eleven patients with type 2 diabetes mellitus, who were diagnosed as having MS, were examined. Vascular-platelet and secondary hemostases and anticoagulant and fibrinolytic systems were evaluated, by performing the complete clinical, laboratory, and instrumental study accepted in a specialized endocrinology clinic. The blood concentrations of high-sensitivity C-reactive protein and proinflammatory cytokines were determined in all the patients with MS and control persons (n=50).Results. It was found that in patients with MS, hemostasis pathology that might be classified as the combined form of a prethrombotic state, which was caused by different types of a constellation of vascular-platelet and plasma hemostases, as well as physiological anticoagulant deficiency, was linked to the laboratory markers and mediators of subclinical inflammation.Conclusion. In the patients with MS, subclinical systemic inflammation is of substantial importance for the mechanisms of a prethrombotic state.

The article deals with studying the degree of increase of the von Willebrand factor and the concentration of endothelin-1 in blood plasma in the subgroups of patients with diabetes mellitus formed depending on of type of disease and presence of phenotype with affection of kidneys. The sampling of 176 patients with diabetes mellitus (65 patients with diabetes mellitus type 1, 111 patients with diabetes mellitus type II) was examined. The control group consisted of 30 healthy persons. In the capacity of biochemical markers of endothelium dysfunction the activity of the von Willebrand factor and the concentration of endothelin-1 in blood were considered. In all patients with diabetes mellitus the biochemical characteristics of endothelium dysfunction are present manifesting by increase of concentration of endothelin-1 in blood which is especially expressed under disease phenotype with affection of kidneys. Despite of the apparent lesion of endothelium in patients with diabetes mellitus compromised with diabetic nephropathy the thrombocytes aggregation induced by ristomicine does not undergo natural changes. Hence, to consider in these patients the increasing activity of the von Willebrand factor as a reliable marker of endothelium dysfunction is not seemed possible.

The article deals with studying the degree of increase of the von Willebrand factor and the concentration of endothelin-1 in blood plasma in the subgroups of patients with diabetes mellitus formed depending on of type of disease and presence of phenotype with affection of kidneys. The sampling of 176 patients with diabetes mellitus (65 patients with diabetes mellitus type I, 111 patients with diabetes melli-tus type II) was examined. The control group consisted of 30 healthy persons. In the capacity of biochemical markers of endothelium dysfunction the activity of the von Willebrandfactor and the concentration of endothelin-1 in blood were consid-ered. In all patients with diabetes mellitus the biochemical characteristics of endo-thelium dysfunction are present manifesting by increase of concentration of endo-thelin-1 in blood which is especially expressed under disease phenotype with affec-tion of kidneys. Despite of the apparent lesion of endothelium in patients with dia-betes mellitus compromised with diabetic nephropathy the thrombocytes aggrega-tion induced by ristomicine does not undergo natural changes. Hence, to consider in these patients the increasing activity of the von Willebrandfactor as a reliable marker of endothelium dysfunction is not seemed possible.

THE AIM. To investigate the activity of free radical processes in alcoholic patients (A), associated with renal damage (A with RD), and the role of depression of effectiveness of regulatory mechanisms, restricting the accumulation of high toxicity products of free radical lipid oxidation (FrLO), in the formation of the nephropathy in these patients. PATIENTS AND METHODS . Were evaluated 57 male patients (mean age of 31 ± 2,8 years), suffering from A during 5-10 years and admitted to the hospital in the state of urgent alcohol abstinence. The renal damage was discovered in 17 (29,8 %) patients. The control group included 20 healthy patients. The activity of FrLO and antioxidant defense was studied. RESULTS . In patients A the values of studied features, showing the activity of FrLO, were statistically higher than those in the healthy group patients. In these patients was discovered the depression of the first and second line mechanisms of AOD. Showed deviation was more obvious in the group of patients A with RD. CONCLUSION . The activation of FrLO developing on the phone of AOD depression, probably, played a role in the development of nephropathy in A patients.

The subjects of this 12-week open non-controlled study of the organoprotective efficiency of eprosartan were 15 patients with chronic glomerulonephritis. The results of the investigation demonstrated high organoprotective activity of eprosartan in a dose of 600 mg a day, which manifested by anti-proteinuric and anti-hematuric effects, as well as positive changes in the parameters of intragromerular filtration, reduction of left ventricular hypertrophy and rigidity, and normalization of the vascularmotor function of the brachial arterial endothelium. To a large extent, the organoprotective activity of eprosartan depends on the unique pharmacodynamic profile of this drug, which is able to decrease excessive functional activity of the sympathetico-adrenal system, which is reflected in the dynamics of the cardiac rhythm dispersion parameters.

The aim of research was comparison of prognostic importance of various indexs non-homogeneousness of processes repolari-zations of heart ventricles registered in acute and subacute periods of myocardial infarction (MI). The retrospective analysis of med-ical histories has allowed to determine dynamics of dispersion of intervals Q-T, Q-Ta and R-Tm in groups of patients with fa-vourable (n = 125) and lethal (n = 250) outcome. The best prognostic importance concerning fatal cardial events have indexs cor-rected on frequency of cardiac rhythm. Most important and independent predictor of intrahospital cardial deaths of the patients with MI is a dispersion of the corrected interval R-Tm, exceeding 80 мс1/2 in the first 6 hours after hospitalization.

The condition of immune homeostasis was studied in 100 patients with chronic renal failure (CRF), including 70 patients on hemodialysis. The patients displayed disbalance in the immune homeostasis characterized by a decrease in the number of CD3+, CD4+, and CD72+ cells, and phagocytosis intensification. Priority Th1-cell response of the immune system tends to intensify during the pre-dialysis period of CRF and becomes the most prominent at the terminal stage.

The purpose of the study was to evaluate the influence of atenolol, a selective, beta1-adrenoblocker, on the quality of life (QL) of patients with old myocardial infarction (MI). The subjects of this 12-month open uncontrolled study were 40 male patients aged 29 to 59 years (mean age 46.8 +/- 1.19) suffering from functional class II-III stable exertional angina, which occurred 6 months after their first large-focal MI. QL was evaluated before and during the course of therapy (after 1, 3, 6, and 12 months) using EORTC QLQ CORE 30, short version of MMPI test, and Spielberg State-Trait Anxiety inventory. The patients received atenolol in effective doses selected on an individual basis (mean day dose was 67.9 +/- 4.2 mg) within one year; the study revealed increase of QL falling in all the categories of EORTC QLQ CORE 30, decrease of reactive and personal anxiety, as well as positive changes in averaged MMPI profile, which reflected lowering of anxiety and depression level in the actual psyche status.