Терапевтический Лекарственный Мониторинг Ламотриджина: Разработка Фармакокинетических Подходов С Целью Индивидуализации Противосудорожной Фармакотерапии

This paper presents the results of therapeutic drug monitoring of lamotrigine, an anticonvulsant epilepsy medication, in patients with cryptogenic focal epilepsy using plasma and saliva as a biological material for drug testing. Comparative analysis of the steady-state plasma and saliva lamotrigine concentrations (Сss MIN and Сss MAX) allows the conclusion that saliva can be used as a suitable biological substrate for therapeutic drug monitoring.