This paper presents the results of therapeutic drug monitoring of lamotrigine, an anticonvulsant epilepsy medication, in patients with cryptogenic focal epilepsy using plasma and saliva as a biological material for drug testing. Comparative analysis of the steady-state plasma and saliva lamotrigine concentrations (Сss MIN and Сss MAX) allows the conclusion that saliva can be used as a suitable biological substrate for therapeutic drug monitoring.

Within the cross, a single, open, randomized study with 10 day washout period, the two sequences has been studied bioequivalence of tablet forms two bisoprolol 18 volunteers (10 mg dosage). Plasma samples were analyzed by a validated HPLC-MS/MS within 48 hours. For preparations analyzed following pharmacokinetic parameters were calculated: AUC 0-t , C max , T max , C max /AUC. 90% confidence interval for log-transformed values for AUC 0-t was 0.9142—1.0568 for C max —0,9371 —1,0473. The study concluded that comparable drugs were bioequivalence of bisoprolol.

Within the cross, a single, open, randomized study with a two-week washout period, the two sequences has been studied bioequivalence of tablet forms two pioglitazone 18 volunteers (30 mg dosage). Plasma samples were analyzed by a validated HPLC-MS/MS within 48 hours. Analyzed for drugs following pharmacokinetic parameters were calculated: AUC 0-t , C max , t max , C max /AUC. 90% confidence interval for log-transformed values of AUC 0-t was 0.945 — 1.066 and C max — 0,871 — 1,044. The study concluded that bioequivalence compared pioglitazone drugs.

Due to the emergence of new technologies in a pharmakokinetics, a pharmacogenetics and analytical chemistry, the medicine comes to qualitatively new stage of development. Therapeutic drug monitoring as the mean of the real time pharmacotherapy efficiency control becomes the basis of rational therapy in modern medicine. In the article various aspects of the therapeutic drug monitoring (TDM) as subsection of clinical pharmacology are discussed. The main indications to carrying out TDM and the main TDM procedures are submitted. Value of TDM for an epileptology is discussed. The special attention is paid to the bioanalytical methods and new methodical approaches (such as non-invasive drug monitoring and equilibrium dialysis) applied in TDM. TDM role as an independent discipline of a medical sciences, with concentration on modern pharmacokinetics computer programs is separately analyzed.