This work is devoted to a comparative analysis of phagocytosis in the healing of infected skin wounds under the influence of antiseptics (chlorhexidine bigluconate and “Anavidin”). Found that in the first study day in all the experimental groups phagocytic index (PI) and indicators of oxygen-biocidity neutrophils (NBT spontaneous and induced) increased with a simultaneous decrease of circulating immune complexes (CIC). Normalization of blood neutrophil phagocytic function in rats with simulated purulent wounds in the processing of “Anavidin” was observed on the 11th day, of chlorhexidine bigluconate – on the 19th day of the study. In the control group – without therapeutic interventions – violations, typical for the development of purulent wounds, have been observed.