Кишечник, как источник бактериемии, токсинемии и развития синдрома полиорганной недостаточности

This review summarizes experimental and clinical data that have attempted to correlate gut permeability, bacterial translocation and other factors with the development of MODS. Delayed sepsis, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) remain major causes of morbidity and mortality in intensive care units. One factor is thought to be important in the aetiology of SIRS. It is intestinal barrier failure resulting in gut permeability, bacterial translocation, and subsequent sepsis. But the presented data suggest that in some patients gut dysfunction may precede the development of MODS. However, in most patients this relationship is less obvious. The gut may still be one of the source of MODS. Bacteria may effect a local gut-associated level in initiating and perpetuating the production of local inflammatory mediators that may produce distant organ injury.