The article presents the results of the experimental study of the effect of standard (Uniflex standard), light-weight (Uniflex light) and composite (Ultrapro, PVDF -M) meshes on the muscles of various regions (anterior and lateral) of the abdominal wall. It has been estimated that the early muscular hypertrophy of fibers may develop after the implantation, and the late development of muscle atrophy and fibrosis. The changes were found not only in a repair spot, but also in the lateral regions of the abdominal wall having no meshes. It has been revealed that light-weight and composite meshes influenced less.