The work was done by using a complex of the modern clinical and instrumental methods. The authors present a new method that they developed for the distal renal sympathetic denervation. Data demonstrated that the effective renal denervation leads to a stable antihypertensive effect, reduction of the left ventricular mass, improvement of diastolic function, normalization of the cerebral arterial autoregulation, decrease in the severity of the structural changes in the brain, and improvement of carbohydrate metabolism in the presence of resistant hypertension associated with diabetes mellitus.