Acetylcholine (ACh, 10-10–10-6 g/ml) dose-dependently increases the rate of erythrocyte agglutination in men. This effect is reduced by selective blockers of M1and M3-cholinergic receptors (ChR): gastrotsepin and 4-DAMP, inhibitor of cyclooxygenase and phospholipase A2 indomethacin, inhibitor of calmodulin trifluoperazine, blocker of Ca2+-dependent K+-channels BaCl2, and blocker of Ca2+-channels verapamil. This means that the effect of ACh is caused by the activation of M1and M3-ChR and involves cyclooxygenase, phospholipase A2, calmodulin and Ca2+and К+-channels.
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