Показатели Неспецифической Клеточной И Гуморальной Резистентности, Компонентов Прооксидантно-Антиоксидантного Равновесия У Потомства Крыс, Родившегося В Условиях Холестаза, Экспериментально Вызванного В Период Фетогенеза

Experiments were performed in 38 rat pups at the age of 15-45 days, 22 of these rats were born from female rats with obturative cholestasis experimentally induced on the 17 th day of pregnancy. The neutrophilic phagocytic activity, complement activity and indices of prooxidant-antioxidant balance were studied. The results showed that the maternal experimental cholestasis developed during the active phetogenesis caused in the litter the steady depression of neutrophilic phagocytic activity in blood, decrease in complement system parameters, more active lipid peroxidation in gastric and renal tissue and the lower a-tocopherol content and catalase activity. The degree of such changes varied depending on organ and age. We investigated the neutrophil phagocytic and complement activity and indices of prooxidant-antioxidant balance in 38 rat pups (15and 45-day-old). Maternal cholestasis experimentally induced on the 17 th day of pregnancy (during the active fetogenesis) led to the prolonged inhibition of neutrophil phagocytic activity, lower levels of complement system substances, more active lipid peroxidation in gastric and renal tissues combined with their lower a-tocopherol content and catalase activity. The degree of such changes depended on organ and age.