The feasibility and safety of use of active immunization in the manifested forms of hepatitis A based on the study of the characteristics of the course of hepatitis on the background of post-exposure vaccination has been carried out. Clinical observation of 245 patients with hepatitis A has been conducted, who were divided into two groups: the main group included 87 people, vaccinated with «Havrix» in the hotbed of infection with following hepatitis A. The comparison group consisted of 158 patients with hepatitis with a natural course of infectious process. The safеty of use of emergency immunization with «Havrix» confirmed by the absence of negative impact of vaccination on the main clinical and laboratory characteristics of the manifested forms of the disease in people with post-exposure vaccination.
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