Purpose of this study is testing manganese and gadolinium sulpho-phthalocyanines aqueous water solutions as contrast agents for MRI. In the fields of 0,5 and 7 Tesla T1 relaxation times were measured and acceleration factors of relaxation for water aqueous solutions of proposed substances were calculated. MRI studies were having done in the field 7 Tesla in rats with C6 glioma before and after injection of proposed substances there were obtained images and T1-cards. The dynamics of tissue contrast was monitored. The measured acceleration factors of relaxation of proposed substances are comparable to the corresponding values for Magnevist TM. Reliable reduction of T1 for 1-2 hours is marked, which leads to a significant increase in signal from the tumor on T1-weighted images. In contrast to known agents drugs based on gadolinium chelates these solutions retain stay longer in the body, which allowing for more detailed MRI studies.
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